Japan - 61st Case of Tamiflu Resistance

[sharon sanders]

hat tip Makoto -


New influenza: The death man in Kurume:First Tamiflu resistant virus confirmation /Fukuoka inside a prefecture.

Kurume City announced on the 26th that it was infected with new influenza and infected with the resistant virus for which the treatment Tamiflu did not work easily last month of man (56) who had died. The example of confirming this virus is the first time in 61 and the prefecture in the whole country.
The man consulted a physician generation of heat according to the city public health center on December 23 last year, the hospital in the city was consulted a physician on the 24th, and it was diagnosed as influenza. Tamiflu is prescribed and it is hospitalized while recuperating home on the 28th due to pneumonia. It died by the respiratory failure on January 18.
〔 Chikugo version 〕


http://www.excite-webtl.jp/world/english/web/?wb_url=http%3A%2F%2Fmainichi.jp%2Farea%2Ffukuoka% 2Fnews%2F20100227ddlk40040419000c.html&wb_lp=JAEN& wb_dis=2&wb_submit=+%96%7C+%96%F3+

[gsgs]

Re: Japan - 61st Case of Tamiflu Resistance

I read it that this was the first case of Tamiflu resistance in
the Fukuoka prefecture out of 61 tested so far.




Wasn't natural tamiflu resistance supposed to be around 4%
according to Roche?

http://translate.google.com/translate?hl=en&sl=ja&u=http://idsc.nih.go.jp/iasr/31/360/inx360-j.html&ei=EXWrS-ysDeSgsQbMrOHFDg&sa=X&oi=translate&ct=result&resnum=6&ved=0CB0Q7gEwBQ&prev=/search%3Fq%3Dsite:http://idsc.nih.go.jp%2BH275Y%2Bh1n1%2B2010%26hl%3Den%26sa%3DG%26ie%3DUTF-8

As a result, a total of 1,403 analyzed strains resistant strain was detected in strain 22, the incidence was 1.6%. However, analysis of this strain, the strain also contains many specimens collected after drug administration, and there are also cases in favor of analysis of suspected cases of clinical drug resistance, the specimen sampling have some bias. This might be a little higher than the actual incidence. The incidence of resistant strains in the United States and abroad was 0.8% (3) is, the market share of domestic epidemic A/H1N1pdm considered equally likely that the incidence of resistant strains. Furthermore, these resistant strains, that were also found scattered geographically and time as well, was considered a sporadic occurrence


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Detection circumstance of the tolerance stocks which were moved aside from the domestic tolerance stocks detection circumstance every place research was shown the area classified by research (chart 1) and classified by area (Figure 1). Tolerance stocks analyzed the part base arrangement of the NA gene mainly, identification did with the presence of tolerance gene marker H275Y. In regard to the stocks of part identification it did with medicine sensitivity test. As a result, tolerance stocks of 22 stocks in entire analytical several 1,403 stocks were detected, occurrence frequency was 1.6%. But, in the latest analytical stocks, after the medicine prescribing the inspection body stocks which were picked and many implication, in addition, preferring the case where medicine tolerance is doubted clinically, an example which you analyze there are, is bias depends on the sampling of the inspection body. Because of this, there is a possibility of being the numerical value which is a little higher than actual occurrence frequency. As for occurrence frequency of the tolerance stocks in foreign country such as the United States 0.8% (3) from the fact that is, also occurrence frequency of A/H1N1pdm tolerance stocks of the city popularity stocks in the country is thought the same perhaps. Furthermore, these tolerance stocks, being scattered timewise and geographically, were thought that from the fact that it is detected, it is sporadic occurrence. Among A/H1N1pdm tolerance stocks of 22 examples which are separated in the country, as for 13 examples from the patient who receives remedy medication, 7 examples were separated from the patient who receives prevention medication, it was thought that tolerance stocks occurred sporadically, due to the selection pressure of the medicine (Figure 1). On the one hand, there is no taking past record of the medicine Sapporo city considerably in regard to 2 examples of the prefecture, the person of tolerance stocks - human infection was doubted. In addition 2 examples of Niigata prefecture (A/Niigata (Niigata) /1233/2009pdm and A/Niigata (Niigata) /1234/2009pdm), the inspection body it is the sample which was picked after the medicine taking, but from the patient inside the same ward we are detected by the same time, the person - it is the case where human infection is strongly doubted. The inside 2 stocks of 22 stocks (A/Niigata (Niigata) /1459/2009pdm and A/Shimane (Shimane) /1062/2009pdm) the mixed sample of tolerance stocks and sensitive strain (275H/Y) is, during medicine taking it is thought the inspection body of the process where tolerance stocks occur with internal of the patient.

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新型インフルエンザウイルス(A/H1N1pdm)オセルタミビル耐性株（H275Y)の国内発生状況［第1報］


New model influenza virus (A/H1N1pdm) [oserutamibiru] tolerance stocks (H275Y) domestic occurrence circumstance [1st report]

オセルタミビル耐

Oseltamivir resistance

[gsgs]

Re: Japan - 61st Case of Tamiflu Resistance

http://idsc.nih.go.jp/iasr/influ-e.html

http://www.grantdowning.com/meetingsites/wcid_2010/wcid2010_slides/monday/6.hayden_influenza_antivirals.pdf