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Dane with novel H1N1 resistant to Tamiflu

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  • Dane with novel H1N1 resistant to Tamiflu

    caution - google translated

    The first case in the world of resistance to influenza drug Tamiflu in people with influenza H1N1 has been found in Denmark.


    Dane resistant to Tamiflu

    29. June 2009

    The first case in the world of resistance to influenza drug Tamiflu in people with influenza H1N1 has been found in Denmark.

    The person is now healthy, and there is no further evidence of infection with resistant virus, according to Statens Serum Institut.

    Det første tilfælde i verden af resistens over for influenza-medicinen Tamiflu hos folk med influenza H1N1 er fundet i Danmark.
    ?Addressing chronic disease is an issue of human rights ? that must be our call to arms"
    Richard Horton, Editor-in-Chief The Lancet

    ~~~~ Twitter:@GertvanderHoek ~~~ GertvanderHoek@gmail.com ~~~

  • #2
    Re: Dane with novel H1N1 resistant to Tamiflu

    They need to publish this sequence!
    Wotan (pronounced Voton with the ton rhyming with on) - The German Odin, ruler of the Aesir.

    I am not a doctor, virologist, biologist, etc. I am a layman with a background in the physical sciences.

    Attempting to blog an nascent pandemic: Diary of a Flu Year

    Comment


    • #3
      Re: Dane with novel H1N1 resistant to Tamiflu

      The person in question was originaly in "close contact" with a person infected
      with H1N1 abroad, and was was given tamiflu preemptive. In spite of the Tamiflu treatment the person developed flu synptoms. The person has now recovered.


      What I was thinking was; Is it possible that the person was already infected ca 48 houres earlier with H1N1, BEFORE getting Tamiflu, a H1N1 infection, at the time, with estreamly mild symptoms and therfore got Tamiflu too late and that the infection then developed into a full H1N1 illness?

      If this is possible, then it?s possible that the virus in question was not resistent.

      Somone with knowhow please let me know.




      29. juni 2009 - Resistens hos pandemisk influenza A H1N1v p?vist i Danmark

      Det f?rste tilf?lde af resistens over for oseltamivir (Tamiflu?) hos det pandemiske influenzavirus A H1N1v er fundet i Danmark. Dette er det f?rste p?viste tilf?lde p? verdensplan.

      Det er velkendt og forventeligt, at influenzavirus kan mutere spontant. Resistensen har ikke ?ndret virus? evne til at smitte eller fremkalde sygdom, og vurderingen er, at der fortsat er tale om en relativ mild influenza.

      Personen er nu rask, og der er ikke p?vist yderligere smitte med det resistente virus. Den smittede var i forebyggende behandling med oseltamivir (Tamiflu?) p? grund af t?t kontakt med et tilf?lde, der var smittet i udlandet. Alligevel fik vedkommende influenzasymptomer. En pr?ve viste, at personen var inficeret med influenzavirus A H1N1v. Yderligere unders?gelser p? Statens Serum Institut har nu vist, at det p?g?ldende virus er muteret. Det er modstandsdygtigt over for det antivirale middel oseltamivir (Tamiflu?), mens zanamivir (Relenza?) fortsat kan anvendes til behandling.

      Verdenssundhedsorganisationen WHO opfordrer p? baggrund af det danske tilf?lde til en ?get opm?rksomhed p? muligheden for udvikling af resistens hos det pandemiske influenzavirus A H1N1v.

      En tilsvarende udvikling af resistens over for oseltamivir (Tamiflu?) er ogs? set hos det vinter-influenzavirus A H1N1, der har cirkuleret de seneste to vinters?soner.

      Det enkelte fund i Danmark er som n?vnt ikke uventet. Det udg?r ikke en risiko for folkesundheden og giver heller ikke anledning til at ?ndre anbefalingerne for brugen af oseltamivir (Tamiflu?).

      I Danmark f?lges situationen fortsat t?t med overv?gning af sygdomsforekomst og unders?gelse af alle isolerede influenzavirus A H1N1v.

      (SSI)

      Comment


      • #4
        Re: Dane with novel H1N1 resistant to Tamiflu

        For questions and discussion, please post at the discussion thread here:



        Because of the importance of the news, another thread was opened in the mainforum,

        please post further news in the main forum thread here:

        ?Addressing chronic disease is an issue of human rights ? that must be our call to arms"
        Richard Horton, Editor-in-Chief The Lancet

        ~~~~ Twitter:@GertvanderHoek ~~~ GertvanderHoek@gmail.com ~~~

        Comment


        • #5
          Re: Dane with novel H1N1 resistant to Tamiflu

          Originally posted by wotan View Post
          They need to publish this sequence!
          I guess you or som of the cheifs of this forum, could try to email K?re M?lbak (H1N1, medical specialist in charge) Statens Serum Institut, Copenhagen, Denmark, and ask him to please publish/share the sequense.



          This is the email to Statens Serum Institut, Copenhagen, Denmark, so just add Att/ K?re M?lbak

          serum@ssi.dk



          Here is a direct email adress to K?re M?lbak (+ info on him), however I?m not sure if it is valid anymore or if it?s an old one:


          Dr. K?re M?lbak
          Department of Epidemiology

          Statens Serum Institute
          5 Artillerivej
          2300 Copenhagen 5

          DENMARK
          Tel: +45 (32) 68 3157
          Fax: +45 (32) 68 3874

          Email: KRM@ssi.dk


          Dr K?re M?lbak is a senior epidemiologist with a special interest in infectious disease epidemiology. He has an extensive research record in diseases transmitted from animals to humans. He became senior medical officer at the the Department of Epidemiology at the Statens Serum Institut in 2003, dealing with surveillance systems, foodborne diseases and CJD.

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