metallo-beta-lactamase 2009 superbug in Australia; and 19 other countries

[Sally Furniss]

3 Australians infected with superbug
13 Aug, 2010 @ 02:02 am AEST | Windsor Genova

Health authorities revealed on Thursday that there are three Australians infected with the superbug or bacteria resistant to antibiotics.

Professor Peter Collignon, head of infectious diseases at Canberra Hospital, said one is in Queensland, another is in Sydney and the third is in the capital. Two of them had just arrived from India, where they were hospitalized.

http://au.ibtimes.com/contents/20100812/3-australians-infected-with-superbug.htm

[Gert van der Hoek]

Re: NDM-1 superbug in Australia

From Maryn McKenna via CNBC:

The resistance factor, known as New Delhi metallo-beta-lactamase, or NDM-1, has already has been found in India and Pakistan, Sweden, the Netherlands, Australia, Canada and the US.
----------------------------------------------

We can add France:

Multidrug resistant germ from India: a first French case

And Belgium:

Belgium: First NDM-1 death was in June

And UK of course:

http://www.flutrackers.com/forum/showthread.php?t=150872

Report from Germany: "Super-bacteria" in Germany

.

[Gert van der Hoek]

Re: NDM-1 superbug in Australia; and 12 other countries

machinetranslated

A patient from Montenegro (former Yugoslavia) was probably infected in Montenegro, transferred to Belgium and cured in Belgium.

Superbacteria found in Montenegrin

15 August 2010th at 06:12

Head of Department at the University miokrobiologije in the Belgian city of Luvenu Yuri Glupčinski said he was not sure whether the patient is, of Montenegrin origin, who was treated for infection superbacteria, infected in Montenegro.

- snip -

The person had the accident in Montenegro, where he was treated for a short time, and that is then transferred to a hospital in Luvenu, Belgium.

[Gert van der Hoek]

Re: NDM-1 superbug in Australia; and 14 other countries

Patient reported from Hong Kong, China:

machinetranslated

NDM-1 virus invasion of Hong Kong

The United Kingdom and the United States and other countries have imported from India found a new super-evil of antibiotic resistance bacteria NDM-1, but the original Hong Kong as early as last October has occurred a case, but central to the Health Protection of Hong Kong on the 12th, that the incident 10 months later confirmed it.

Edit: link to article with some more on the Hong Kong patient with "NDM-1" :


Patient beats superbug as fears of global spread rise

Mary Ann Benitez and Natalie Wong

Friday, August 13, 2010

A new superbug resistant to all known drugs struck an Indian man in the first known case in Hong Kong.

More (in English): http://www.thestandard.com.hk/news_d...=20100813&fc=7

[Diane Morin]

Re: NDM-1 superbug in Australia; and 13 other countries

Machine translation
Published on August 13, 2010 with 06h53 | Updated on August 13, 2010 at 07h01

An Indian superbactery in Canada

<TABLE class=MsoNormalTable cellSpacing=0 cellPadding=0 border=0><TBODY><TR><TD style="PADDING-RIGHT: 0.75pt; PADDING-LEFT: 0.75pt; PADDING-BOTTOM: 0.75pt; PADDING-TOP: 0.75pt">

</TD><TD style="PADDING-RIGHT: 0.75pt; PADDING-LEFT: 0.75pt; PADDING-BOTTOM: 0.75pt; PADDING-TOP: 0.75pt">Mathieu Perreault
The Press

</TD></TR></TBODY></TABLE>A new superbactery, of Indian origin, makes the medical cuffs this week. Two cases are already declared in Canada.

“The two Canadians had visited India”, explains Johann Pitout, microbiologist at the University of Calgary, which signs a comment accompanying a British study on the bacterial change New Delhi metal-worker-beta-lactamase (NDM-1) in the review The Lancet. “It is worrying because the change touches a type of bacteria, thenegative ones, for which there are less antibiotics than for thepositive ones like the gilded staphilococcus. There has been very few pharmaceutical research on the gram-negative bacteria for two decades. All the efforts were put on the gilded staphilococcus. There are only two antibiotics which can treat the patients infected by bacterium NDM-1, against five or six for the gram-positive bacteria multir&#233;sistantes.”


/.../

The Agency of public health of Canada minimizes the problem, which pushed the British medical authorities with launching an alarm to resistance in April 2009. “It is not different from the problem of the multir&#233;sistance other bacteria”, indicates Howard Njoo, directing general of the Center of fight against the transmissible diseases and the infections of the Agency. Of the two Canadian patients, one of Alberta and the other of the Colombia-British, none had contracted its infection because of medical tourism.

/.../

http://www.cyberpresse.ca/sciences/m...-au-canada.php

See also on the French-speaking forum

Une bact&#233;rie ultrar&#233;sistante se r&#233;pand

NDM-1 - Europe

[Giuseppe]

Re: NDM-1 superbug in Australia; and 13 other countries

For an accurate classification of antibacterial chemotherapeutic agents, see also Merck Manual at http://www.merck.com/mmpe/sec14/ch170/ch170a.html

It is useful to see how for the various species of bacteria there are different agents suggested for clinical use.

[Giuseppe]

Re: NDM-1 superbug in Australia; and 13 other countries

Another useful link on Merck Manual: http://www.merck.com/mmpe/sec14/ch170/ch170p.html

This page describes tigecyclin - a relatively novel antibiotic useful in multi-resistant gram-negative germs infections.

[Gert van der Hoek]

Re: NDM-1 superbug in Australia; and 14 other countries

NDM-1 was reported from:

India, Pakistan, Sweden, Netherlands, Australia, Canada, USA, France, Belgium, UK, Germany, Montenegro, Hong Kong

we can add: Kenya and Oman.

- snip -

One thing is certain: it is a [French] patient who was hospitalized in India as in all
cases we have found in Kenya, Australia and the Sultanate of Oman.


translated from French;

source: http://www.lepoint.fr/sante/ndm-1-ce...1225009_40.php

[Gert van der Hoek]

Re: NDM-1 superbug in Australia; and 15 other countries

Report from Malaysia:

- snip -

Currently, he said, E. coli (gut bacteria) and pneumonia bacteria resistance to carbapenems, a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity in Malaysia was low, approximately only 0.2 percent.

source : http://www.mysinchew.com/node/43425

[Gert van der Hoek]

Re: metallo-beta-lactamase superbug in Australia; and 15 other countries

More from Hong Kong; infected patient fully recovered.


Hong Kong: CHP attaches great importance to antibiotic resistant bacteria

Submitted by editor on August 12, 2010 -

A spokesman for the Centre for Health Department (CHP) of the Department of Health today (August 12) said CHP attached great importance to an overseas report concerning the emergence of new antibiotic resistant organisms harbouring New Delhi metallo-?]-lactamase 1 (NDM-1).

NDM-1 is an enzyme which can inactivate certain groups of antibiotics (e.g., carbapenems, beta-lactams), thus conferring multi-drug resistance to bacteria bearing this enzyme.

We are following up with the World Health Organization and the respective health authorities to understand more of the situation, a CHP spokesman said.

We are also liaising with hospital laboratories to formalise an enhanced surveillance arrangement for such organisms.

The spokesman noted that CHPs Public Health Laboratory Services Branch (PHLSB) had all along been monitoring the antibiotic resistance pattern of bacteria.

According to test results of PHLSB, there was one isolate of E. coli harbouring NDM-1 in a 66-year-old male patient attending a government out-patient clinic in October 2009.

The organism was however susceptible to oral antibiotic agents commonly used to treat urinary tract infection, the spokesman said.

The patient fully recovered.

CHP will issue letters to doctors to alert them of the situation and will remain vigilant for changes in antibiotic resistance that may have public health significance, he added.

http://www.webnewswire.com/node/563610

[Gert van der Hoek]

Re: metallo-beta-lactamase 2009 superbug in Australia; and 16 other countries

machinetranslated

New antibiotic-resistant bacteria detected in Portugal

The Directorate General of Health says bacteria NDM-1 is already in Portugal and there is no way to resist him, but ensures that measures are being prepared to combat infections.

full article in Portugese:

http://sic.sapo.pt/online/noticias/vida/DGS%20admite%20que%20ha%20em%20Portugal%20casos%20de%20NDM%201.htm

[Gert van der Hoek]

Re: metallo-beta-lactamase 2009 superbug in Australia; and 17 other countries

In a previously reported article I missed another country:


The reservoir is located in the Indian subcontinent: Pakistan, India, Bangladesh

Original in French.



Thanks to Muscade

[Gert van der Hoek]

Re: metallo-beta-lactamase 2009 superbug in Australia; and 17 other countries

An overview in French:

http://www.flutrackers.com/forum/showthread.php?t=151124

.

[Gert van der Hoek]

Re: metallo-beta-lactamase 2009 superbug in Australia; and 18 other countries

Via Crofsblogs this report from Vietnam:

Vietnam discovers superbugs amid world concern

Last updated: 8/13/2010 13:50

As the world frets over a new enzyme capable of making bacterial strains resistant to most antibiotics, Vietnam?s experts announced Thursday that they have discovered several "superbug" strains here.

The multi-drug resistance has mostly been discovered in ?gram-negative? gut bugs, according to Nguyen Trung Cap, vice chief of emergency department at the National Hospital for Tropical Diseases.

Vietnam has yet to conduct any research on antibiotic resistant bacteria, so experts here can?t say if the recorded superbugs carry the troublesome NDM-1 gene (also known as New Delhi metallo-beta-lactamose), Cap said.

More : http://www.thanhniennews.com/2010/Pa...813134537.aspx



India, Pakistan, Bangladesh, Vietnam, Malaysia , Hong Kong.

United Kingdom, Sweden, Netherlands, Belgium, Germany, France, Portugal , Montenegro.

Australia, Canada, USA.

Kenya, Oman.

[Diane Morin]

Re: metallo-beta-lactamase 2009 superbug in Australia; and 18 other countries

+ New Zealand



"The Ministry of Health says the global spread of drug-resistant organisms is one of the inherent risks of having surgery in other countries and there was one case of a person with a superbug in New Zealand early this year."

http://www.nzherald.co.nz/nz/news/article.cfm?c_id=1&objectid=10665873