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http://www.ncbi.nlm.nih.gov/pubmed/22052986
http://www.medscape.com/viewarticle/770268
Proanthocyanidins and other flavonoids in relation to pancreatic cancer: a case-control study in Italy.
Ann Oncol. 2012; 23(6):1488-93 (ISSN: 1569-8041)
Rossi M; Lugo A; Lagiou P; Zucchetto A; Polesel J; Serraino D; Negri E; Trichopoulos D; La Vecchia C
Department of Epidemiology, Mario Negri Institute for Pharmacological Research, Milan, Italy.
BACKGROUND: Four cohort studies have examined the relation between flavonoids and pancreatic cancer risk providing inconsistent results.
PATIENTS AND METHODS: We conducted a case-control study between 1991 and 2008 in Northern Italy. Subjects were 326 cases with incident pancreatic cancer and 652 frequency-matched controls (admitted to the same hospitals as cases for acute non-neoplastic conditions) who answered a reproducible and valid food-frequency questionnaire. We computed odds ratios (ORs) using logistic regression models conditioned on gender, age and study center, and adjusted for education, history of diabetes, tobacco smoking, alcohol drinking and energy intake.
RESULTS: Proanthocyanidins with three or more mers were inversely related to pancreatic cancer risk. The ORs were similar in all classes of polymers with three or more mers and in their combination (OR for the highest versus the lowest quintile of intake, 0.41; 95% confidence interval 0.24-0.69), and did not substantially change after adjustment for fruit and vegetable consumption, and for vitamin C and folate intakes. Eating an additional portion of fruits rich in proanthocyanidins every day reduced the risk of pancreatic cancer by 25%.
CONCLUSION: Dietary proanthocyanidins-mostly present in apples, pears and pulses-may convey some protection against pancreatic cancer risk.
Ann Oncol. 2012; 23(6):1488-93 (ISSN: 1569-8041)
Rossi M; Lugo A; Lagiou P; Zucchetto A; Polesel J; Serraino D; Negri E; Trichopoulos D; La Vecchia C
Department of Epidemiology, Mario Negri Institute for Pharmacological Research, Milan, Italy.
BACKGROUND: Four cohort studies have examined the relation between flavonoids and pancreatic cancer risk providing inconsistent results.
PATIENTS AND METHODS: We conducted a case-control study between 1991 and 2008 in Northern Italy. Subjects were 326 cases with incident pancreatic cancer and 652 frequency-matched controls (admitted to the same hospitals as cases for acute non-neoplastic conditions) who answered a reproducible and valid food-frequency questionnaire. We computed odds ratios (ORs) using logistic regression models conditioned on gender, age and study center, and adjusted for education, history of diabetes, tobacco smoking, alcohol drinking and energy intake.
RESULTS: Proanthocyanidins with three or more mers were inversely related to pancreatic cancer risk. The ORs were similar in all classes of polymers with three or more mers and in their combination (OR for the highest versus the lowest quintile of intake, 0.41; 95% confidence interval 0.24-0.69), and did not substantially change after adjustment for fruit and vegetable consumption, and for vitamin C and folate intakes. Eating an additional portion of fruits rich in proanthocyanidins every day reduced the risk of pancreatic cancer by 25%.
CONCLUSION: Dietary proanthocyanidins-mostly present in apples, pears and pulses-may convey some protection against pancreatic cancer risk.
Will an Apple a Day Keep Pancreatic Cancer Away?
David J. Kerr, MD
Sep 07, 2012
[snip]
As we get older, we all become epidemiologists and public health doctors. As medical oncologists, we have a duty to start promulgating some of this interesting work. This is a very well-designed study, very well delivered, and in keeping broadly with other evidence out there. The take-home message for us, for our families, and for the population of patients we care for is that an apple a day may indeed keep pancreatic cancer away.
David J. Kerr, MD
Sep 07, 2012
[snip]
As we get older, we all become epidemiologists and public health doctors. As medical oncologists, we have a duty to start promulgating some of this interesting work. This is a very well-designed study, very well delivered, and in keeping broadly with other evidence out there. The take-home message for us, for our families, and for the population of patients we care for is that an apple a day may indeed keep pancreatic cancer away.