Week 42: Sporadic
? Overall, there is influenza activity continues to be low in Pennsylvania
? Over the last three weeks, we have not seen an increase in flu-related Emergency Department (ED) and out patient doctor-visits in all regions of the state.
? However, we saw a slight increase in the number influenza lab reports last week (week 42) when 16 cases were reported, which is double the number (15) reported during the first two weeks of the season. It is, however, important to note that a majority of reported cases are positive by rapid diagnostic tests which tend to give false positive results this early into the flu season.
? During week 42, the state lab confirmed our first lab confirmed influenza cases - both were influenza A/H3N2. Nealy all (98%) of respiratory specimens that had undergone rapid diagnostic testing (and were positive)prior to submission to the state lab tested negative for influenza at the state lab -- suggesting that most influenza-like illnesses at this time are caused by non-flu organisms, particularly Rhinovirus.
? No flu-related hospitalizations was reported during week 42
? No flu-related death has been reported season-to-date, 11 total deaths were reported last season.
? No flu-related outbreaks were reported season to date. Last season, 23 outbreaks were reported. Most of the outbreaks in long term care facilities were associated with the A/H3 virus subtypes, which commonly causes severe disease and outcomes among the elderly.
? Of the 594 influenza virus specimens tested for resistance to influenza antiviral medication by CDC, only one 2009 H1N1 influenza A (H1N1) virus was found to be resistance to oseltamivir, but sensitive to zanamivir. It contained the H275Y mutation in the neuraminidase.
o High levels of resistance to the adamantanes (amantadine and rimantadine) persist among 2009 influenza A (H1N1) and A (H3N2) viruses currently circulating globally. Influenza B viruses are not susceptible to adamantanes.
o All H3N2v viruses that were tested were sensitive to oseltamivir
o The vast majority of influenza A viruses that were antigenically characterized were closely related to the components included in the 2012-2013 seasonal influenza vaccine for the Northern Hemisphere.
? Overall, there is influenza activity continues to be low in Pennsylvania
? Over the last three weeks, we have not seen an increase in flu-related Emergency Department (ED) and out patient doctor-visits in all regions of the state.
? However, we saw a slight increase in the number influenza lab reports last week (week 42) when 16 cases were reported, which is double the number (15) reported during the first two weeks of the season. It is, however, important to note that a majority of reported cases are positive by rapid diagnostic tests which tend to give false positive results this early into the flu season.
? During week 42, the state lab confirmed our first lab confirmed influenza cases - both were influenza A/H3N2. Nealy all (98%) of respiratory specimens that had undergone rapid diagnostic testing (and were positive)prior to submission to the state lab tested negative for influenza at the state lab -- suggesting that most influenza-like illnesses at this time are caused by non-flu organisms, particularly Rhinovirus.
? No flu-related hospitalizations was reported during week 42
? No flu-related death has been reported season-to-date, 11 total deaths were reported last season.
? No flu-related outbreaks were reported season to date. Last season, 23 outbreaks were reported. Most of the outbreaks in long term care facilities were associated with the A/H3 virus subtypes, which commonly causes severe disease and outcomes among the elderly.
? Of the 594 influenza virus specimens tested for resistance to influenza antiviral medication by CDC, only one 2009 H1N1 influenza A (H1N1) virus was found to be resistance to oseltamivir, but sensitive to zanamivir. It contained the H275Y mutation in the neuraminidase.
o High levels of resistance to the adamantanes (amantadine and rimantadine) persist among 2009 influenza A (H1N1) and A (H3N2) viruses currently circulating globally. Influenza B viruses are not susceptible to adamantanes.
o All H3N2v viruses that were tested were sensitive to oseltamivir
o The vast majority of influenza A viruses that were antigenically characterized were closely related to the components included in the 2012-2013 seasonal influenza vaccine for the Northern Hemisphere.
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