Analysis - HA 166N Polymorphism Potential on pH1N1 Cross-Clade Background with Both 188T and 189T

[sharon sanders]

hat tip NS1 at Genewurx

2013-02-26

HA 166N Polymorphism Potential on pH1N1 Cross-Clade Background with Both 188T and 189T


Current trending indicates a reportable potential for the K166N polymorphism spreading on the Hemagglutinin of pH1N1. This change may enhance Vaccine Escape from the currently selected vaccine target candidate, CA/07 X181.

The GeneWurx RnR model approximates that HA 166N may appear on a pH1N1 cross-clade background carrying both 188T and 189T, according to the following probabilities.

• 28% probability sampled by 2013-04-30.
• 52% probability sampled by 2013-09-30.

If the HA 166N does appear on a cross-clade background having both 188T and 189T, hospitalisation of subjects under 12 years of age is a potential scenario.

These probabilities will be updated as additional data is made public. Transparency at this post-pandemic stage is essential to formulate viable responses for the risk groups. Release of sequences and clinical data of a finer detail and higher quantity will allow information-based decisions.

http://pf11.blogspot.com/2013/02/ha-166n-polymorphism-potential-on-ph1n1.html

[NS1]

Re: Analysis - HA 166N Polymorphism Potential on pH1N1 Cross-Clade Background with Both 188T and 189T

Prediction
Demonstrated in USA
Triple Polymorphism pH1N1
HA 166N, 188T & 189T

2013-11-28

The United States CDC published a sequence on 2013-09-09 with Clade Crossing evidence sampled on 2013-08-13 from a 57 year old male in Indiana. This Indiana22_C2_57M_2013_08_13 sequence fulfills the triple polymorphism genetic change and timing of the prediction published on 2013-02-26 titled HA 166N Polymorphism Potential on pH1N1 Cross-Clade Background with Both 188T and 189T.

• Open-Access, Full-Text Investigational Analytic including Genetic Details