TWiV 229: Partly cloudy with a high of H7N9
<abbr class="published" title="2013-04-21">April 21, 2013</abbr>
Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, and Alan Dove
Vincent, Rich, Dickson, and Alan review the current status of human infections with avian influenza H7N9 virus.
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Download TWiV 229 (69 MB .mp3, 95 min)
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Links for this episode:
Notes by Gsgs below:
twiv229,recorded Apr.19,2013
17:30 first mention of H7N9
eye-infection of H7
21:40 mild undetected cases
(but they checked hundreds of contacts and didn't find them)
23:00 adaptive mutations accumulate ?
(it also mutates and is selected in the host, trying to replicate
better, and in more cells)
30:00, infection,transmission 34:00 exists an example where a
virus mutated in a human to gain transmissiability
37:00 profvrr thinks it's been in poultry for a while and did not
cause h2h, so it can't
44:20 S1 and A1 very different --> 2 introductions
45:40 reassortment in avian host, they don't know that
53:30 thinks the humans must have special genetics to be suspectible
55:20 AD thinks reassortment in swine is more likely
( http://www.flutrackers.com/forum/sho...d.php?t=203696 , showing why H1N1 is critical)
57:00 many sporadic H7--> humans before (but H7s are different
and also the other segments, so you can't really compare, no H7+H9N2 before)
1:00:00 3* don't think this is a pandemic strain, again no probability estimates
but from the whole atmosphere I conclude that it's <5%, and they presumably
think it would attenuate a lot, they don't take it serious, not in the picks,joking)
1:02:00 how many people get pandemic vaccine (~80% in Sweden,Norway)
1:06:00 in some decades we may understand this , how flu goes pandemic.
(but do we want that ? --> dual use !)
1:08 emails
<abbr class="published" title="2013-04-21">April 21, 2013</abbr>
Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, and Alan Dove
Vincent, Rich, Dickson, and Alan review the current status of human infections with avian influenza H7N9 virus.
Click arrow to play
Download TWiV 229 (69 MB .mp3, 95 min)
Subscribe (free): iTunes, RSS, email
Links for this episode:
- Hilary Koprowski, 96 (NY Times)
- Koprowski, Kessin, Racaniello photo
- Listen to the Music by Roger Vaughan
- Influenza ocular infections (one, two)
- H7N9 global concerns (NEJM)
- Human infection with H7N9 (NEJM)
- WHO Global Alert and Response, H7N9
- Avian influenza A(H7N9) virus (WHO)
- Novel H7N9 reassortant, implications for Europe (Eurosurveill)
- Genetic analysis of H7N9 (Eurosurveill)
- H7N9 compared with H7N7 outbreaks (Eurosurveill)
- Image credit: Eurosurveillance
- Letters read on TWiV 229
Notes by Gsgs below:
twiv229,recorded Apr.19,2013
17:30 first mention of H7N9
eye-infection of H7
21:40 mild undetected cases
(but they checked hundreds of contacts and didn't find them)
23:00 adaptive mutations accumulate ?
(it also mutates and is selected in the host, trying to replicate
better, and in more cells)
30:00, infection,transmission 34:00 exists an example where a
virus mutated in a human to gain transmissiability
37:00 profvrr thinks it's been in poultry for a while and did not
cause h2h, so it can't
44:20 S1 and A1 very different --> 2 introductions
45:40 reassortment in avian host, they don't know that
53:30 thinks the humans must have special genetics to be suspectible
55:20 AD thinks reassortment in swine is more likely
( http://www.flutrackers.com/forum/sho...d.php?t=203696 , showing why H1N1 is critical)
57:00 many sporadic H7--> humans before (but H7s are different
and also the other segments, so you can't really compare, no H7+H9N2 before)
1:00:00 3* don't think this is a pandemic strain, again no probability estimates
but from the whole atmosphere I conclude that it's <5%, and they presumably
think it would attenuate a lot, they don't take it serious, not in the picks,joking)
1:02:00 how many people get pandemic vaccine (~80% in Sweden,Norway)
1:06:00 in some decades we may understand this , how flu goes pandemic.
(but do we want that ? --> dual use !)
1:08 emails
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