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TWiV 229, H7N9

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  • TWiV 229, H7N9

    TWiV 229: Partly cloudy with a high of H7N9

    <abbr class="published" title="2013-04-21">April 21, 2013</abbr>

    Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, and Alan Dove

    Vincent, Rich, Dickson, and Alan review the current status of human infections with avian influenza H7N9 virus.

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    Download TWiV 229 (69 MB .mp3, 95 min)
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    Links for this episode:





    Notes by Gsgs below:




    twiv229,recorded Apr.19,2013
    17:30 first mention of H7N9
    eye-infection of H7
    21:40 mild undetected cases
    (but they checked hundreds of contacts and didn't find them)
    23:00 adaptive mutations accumulate ?
    (it also mutates and is selected in the host, trying to replicate
    better, and in more cells)
    30:00, infection,transmission 34:00 exists an example where a
    virus mutated in a human to gain transmissiability
    37:00 profvrr thinks it's been in poultry for a while and did not
    cause h2h, so it can't
    44:20 S1 and A1 very different --> 2 introductions
    45:40 reassortment in avian host, they don't know that
    53:30 thinks the humans must have special genetics to be suspectible
    55:20 AD thinks reassortment in swine is more likely
    ( http://www.flutrackers.com/forum/sho...d.php?t=203696 , showing why H1N1 is critical)
    57:00 many sporadic H7--> humans before (but H7s are different
    and also the other segments, so you can't really compare, no H7+H9N2 before)
    1:00:00 3* don't think this is a pandemic strain, again no probability estimates
    but from the whole atmosphere I conclude that it's <5&#37;, and they presumably
    think it would attenuate a lot, they don't take it serious, not in the picks,joking)
    1:02:00 how many people get pandemic vaccine (~80% in Sweden,Norway)
    1:06:00 in some decades we may understand this , how flu goes pandemic.
    (but do we want that ? --> dual use !)
    1:08 emails
    Last edited by sharon sanders; April 21, 2013, 11:23 AM. Reason: added top from Vincent's blog
    I'm interested in expert panflu damage estimates
    my current links: http://bit.ly/hFI7H ILI-charts: http://bit.ly/CcRgT

  • #2
    Re: TWiV 229, H7N9

    Great gsgs, for not mother-tongue English, this brief summary is very useful.

    Comment


    • #3
      Re: TWiV 229, H7N9

      I like Vincent's voice, easy to understand for me. Better than
      most other audios that I watched to.

      Except when he says: the coooint that makes you sssick
      took me a while to figure out that one.

      I also remember that pomia,pnomia,pmumia,pnuomia,pneumonia
      took me a while too, how they swallow syllables
      I'm interested in expert panflu damage estimates
      my current links: http://bit.ly/hFI7H ILI-charts: http://bit.ly/CcRgT

      Comment

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