many secondary Alzheimer deaths ?

gsgs

Registered User

Join Date: Feb 2006

Posts: 11496
- Share
- Tweet
#1

many secondary Alzheimer deaths ?

March 6, 2014, 12:29 PM

Contribution of Alzheimer disease to mortality in the United States

http://www.neurology.org/content/early/2014/03/05/WNL.0000000000000240

Objective: To assess the burden of mortality attributable to Alzheimer disease (AD) dementia in the United States. Methods: Data came from 2,566 persons aged 65 years and older (mean 78.1 years) without dementia at baseline from 2 cohort studies of aging with identical annual diagnostic assessments of dementia. Because both studies require organ donation, ascertainment of mortality was complete and dates of death accurate. Mortality hazard ratios (HRs) after incident AD dementia were estimated per 10-year age strata from proportional hazards models. Population attributable risk percentage was derived to estimate excess mortality after a diagnosis of AD dementia. The number of excess deaths attributable to AD dementia in the United States was then estimated. Results: Over an average of 8 years, 559 participants (21.8%) without dementia at baseline developed AD dementia and 1,090 (42.4%) died. Median time from AD dementia diagnosis to death was 3.8 years. The mortality HR for AD dementia was 4.30 (confidence interval = 3.33, 5.58) for ages 75–84 years and 2.77 (confidence interval = 2.37, 3.23) for ages 85 years and older (too few deaths after AD dementia in ages 65–74 were available to estimate HR). Population attributable risk percentage was 37.0% for ages 75–84 and 35.8% for ages 85 and older. An estimated 503,400 deaths in Americans aged 75 years and older were attributable to AD dementia in 2010. Conclusions: A larger number of deaths are attributable to AD dementia in the United States each year than the number (<84,000 in 2010) reported on death certificates. AD= : Alzheimer disease; CDC= : Centers for Disease Control and Prevention; HR= : hazard ratio; PAR%= : population attributable risk percentage

Alzheimer?s disease likely plays a much larger role in the deaths of older Americans than is reported, according to a new study that says the disease may be the third-leading cause of death in the United States.
The Centers for Disease Control and Prevention lists Alzheimer?s as the sixth-leading cause of death, far below heart disease and cancer. But the new report, published Wednesday in the medical journal of the American Academy of Neurology, suggests that the current system of relying on death certificates for causes misses the complexity of dying for many older people and underestimates the impact of Alzheimer?s

estimating 503400 US-deaths >74y from Alzheimer dementia in 2010.
while NCHS gives 78341 or 110005 where Alzheimer is mentioned anywhere on the death-certificate.
To compare: deaths from pneumonia were 49770, but deaths where pneumonia was mentioned anywhere
were 189225. or diabetes: 69147 and 234330

Alzheimer deaths are interesting for the gs, because they are pretty much seasonal
and homologous with flu-waves.

I'm interested in expert panflu damage estimates
my current links: http://bit.ly/hFI7H ILI-charts: http://bit.ly/CcRgT
Tags: None

Announcement

many secondary Alzheimer deaths ?