Announcement

**tropical** · July 23, 2008, 06:50 AM

Re: _|ANTIVIRAL RESISTANCE BAFFLES SCIENTISTS|_

Thank you Kent.

**HenryN** · July 23, 2008, 07:14 AM

Re: _|ANTIVIRAL RESISTANCE BAFFLES SCIENTISTS|_

Originally posted by tropical View Post

#148, Kent.N.
"ProMED: ...
Laboratory tests on 6 samples of the H5N1 strain of avian influenza collected from poultry in Indonesia in 2005 showed they were between 15 and 30 times less sensitive to Tamiflu than a family of the viruses collected in Southeast Asia a year earlier."

Does the above means results from poultry lab. experiments provenience,
or inc. folks treated infected farming poultry with Tamiflu antivirals and those poultry exibited than the above lab results of resistance?

The antiviral resiatnce was reported at the Options VI meeting over a year ago (which means they had the data almost 2 years ago). These results would be for testing of H5N1 from samples. There was no specific change (like H274Y) in the isolates.
The only human H5N1 sequence I know of is from the Karo patient who stopped taking his Tamiflu. He died and H274Y was in his H5N1 sequence.
Tamiflu is dispersed like candy in Indonesia, and the last public human sequence was from January, 2007.
It is likely that there is unreported H274Y in H5N1 and H1N1 in Indonesia.

**HenryN** · July 23, 2008, 07:18 AM

Re: _|ANTIVIRAL RESISTANCE BAFFLES SCIENTISTS|_

Originally posted by miso View Post

Dr Niman,
Thank you for spending time on my questions. Obviously I have a lot to learn with regards to sequencing and interpreting NCBI data. The data you are relying on seems to be contributed by two groups. One that does not mention zanamivir in their submissions (as I noted in an above post) and the other group who seem to be submitting a mix of influenza data with no mention of zanamivir and a title for an as yet unpublished paper. The sooner they are published, the sooner we'll (I'll) know degrees of resistance, viability of the resistant strain etc.
I would have thought this would have been a priority for the medical community, an opportunity to say Relenza is as big a dud as Tamiflu (as happened with the behaviour warning from Japan).

LOCUS CY030873 1396 bp cRNA linear VRL 17-MAR-2008
DEFINITION Influenza A virus (A/Thailand/39/2008(H1N1)) segment 6 sequence.
ACCESSION CY030873
VERSION CY030873.1 GI:170026929
KEYWORDS .
SOURCE Influenza A virus (A/Thailand/39/2008(H1N1))
ORGANISM Influenza A virus (A/Thailand/39/2008(H1N1))
Viruses; ssRNA negative-strand viruses; Orthomyxoviridae;
Influenzavirus A.
REFERENCE 1 (bases 1 to 1396)
AUTHORS Hurt,A.C., Kelso,A. and Barr,I.G.
TITLE Community cases of zanamivir-resistant human influenza viruses with
a novel mutation in the neuraminidase gene
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 1396)
AUTHORS Hurt,A.C., Deng,Y.-M. and Komadina,N.
TITLE Direct Submission
JOURNAL Submitted (14-MAR-2008) WHO Collaborating Centre for Reference and
Research on Influenza, 45 Poplar Rd, Parkville, Victoria 3052,
Australia
FEATURES Location/Qualifiers
source 1..1396
/organism="Influenza A virus (A/Thailand/39/2008(H1N1))"
/mol_type="viral cRNA"
/strain="A/Thailand/39/2008(H1N1)"
/serotype="H1N1"
/isolation_source="gender:M; age:23"
/specific_host="Human"
/db_xref="taxon:511421"
/segment="6"
/lab_host="MDCKX passage(s)"
/country="Thailand"
/collection_date="02-Jan-2008"
gene 1..>1396
/gene="NA"
CDS 1..>1396
/gene="NA"
/codon_start=1
/product="neuraminidase"
/protein_id="ACB05991.1"
/db_xref="GI:170026930"
/translation="MNPNQKIITIGSISIAIGIISLMLQIGNIISIWASHS IQTGSQN
NTGICNQRIITYENSTWVNHTYVNINNTNVVAGEDKTSVTLAGNSSLCSI SGWAIYTK
DNSIRIGSKGDVFVIREPFISCSHLECRTFFLTKGALLNDKHSNGTVKDR SPYRALMS
CPLGEAPSPYNSKFESVAWSASACHDGMGWLTIGISGPDNGAVAVLKYNG IITGTIKS
WKKQILRTQESECVCMNGSCFTIMTDGPSNKAASYKIFKIEKGKVTKSIE LNAPNFHY
EECSCYPDTGIVMCVCRDNWHGSNRPWVSFNQNLDYQIGYICSGVFGDNP RPEDGEGS
CNPVTVDGANGVKGFSYKYDNGVWIGRTKSNRLRKGFEMIWDPNGWTNTD SDFSVKQD
VVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELVRGLPRENTTIWTSGS SISFCGVN
SDTANWSWPDGAELP"
ORIGIN
1 atgaatccaa atcaaaaaat aataaccatt ggatcaatca gtatagcaat cggaataatt
61 agtctaatgt tgcaaatagg aaatattatt tcaatatggg ctagtcactc aatccaaact
121 ggaagtcaaa acaacactgg aatatgcaac caaagaatca tcacatatga aaacagcacc
181 tgggtgaatc acacatatgt taatattaac aacactaatg ttgttgcagg agaggacaaa
241 acttcagtga cattggccgg caattcgtct ctttgttcta tcagtggatg ggctatatac
301 acaaaagaca acagcataag aattggctcc aaaggagatg tttttgtcat aagagaacct
361 ttcatatcat gttctcactt ggaatgcaga accttttttc tgaccaaagg cgctctatta
421 aatgacaaac attcaaatgg gaccgtaaag gacagaagtc cttatagggc cttaatgagc
481 tgtcctctag gtgaagctcc gtccccatac aattcaaagt tcgaatcagt tgcatggtca
541 gcaagcgcat gccatgatgg catgggctgg ttaacaatcg gaatttctgg tccagacaat
601 ggagctgtgg ctgtactaaa atacaacgga ataataactg gaaccataaa aagttggaaa
661 aagcaaatat taagaacaca agagtctgaa tgtgtctgta tgaacgggtc atgtttcacc
721 ataatgaccg atggcccgag taataaggcc gcctcgtaca aaattttcaa gatcgaaaag
781 gggaaggtta ctaaatcaat agagttgaat gcacccaatt ttcattatga ggaatgttcc
841 tgttacccag acactggcat agtgatgtgt gtatgcaggg acaactggca tggttcaaat
901 cgaccttggg tgtcttttaa tcaaaacttg gattatcaaa taggatacat ctgcagtgga
961 gtgttcggtg acaatccgcg tcccgaagat ggagagggca gctgcaatcc agtgactgtt
1021 gatggagcaa acggagtaaa agggttttca tacaaatatg ataatggtgt ttggatagga
1081 aggaccaaaa gtaacagact tagaaagggg tttgagatga tctgggatcc taatggatgg
1141 acaaataccg acagtgattt ctcagtgaaa caggatgttg tagcaataac tgattggtca
1201 gggtacagcg gaagtttcgt ccaacatcct gagttaacag gattggactg tataagacct
1261 tgcttctggg ttgagttagt cagagggctg cctagagaaa atacaacaat ttggactagt
1321 gggagcagca tttctttttg tggcgttaat agtgatactg caaactggtc ttggccagac
1381 ggtgctgagt tgccat

**HenryN** · July 23, 2008, 07:23 AM

Re: _|ANTIVIRAL RESISTANCE BAFFLES SCIENTISTS|_

Originally posted by miso View Post

Dr Niman,
Thank you for spending time on my questions. Obviously I have a lot to learn with regards to sequencing and interpreting NCBI data. The data you are relying on seems to be contributed by two groups. One that does not mention zanamivir in their submissions (as I noted in an above post) and the other group who seem to be submitting a mix of influenza data with no mention of zanamivir and a title for an as yet unpublished paper. The sooner they are published, the sooner we'll (I'll) know degrees of resistance, viability of the resistant strain etc.
I would have thought this would have been a priority for the medical community, an opportunity to say Relenza is as big a dud as Tamiflu (as happened with the behaviour warning from Japan).

Abstract of CDC presentation at Options VI
Abstract O66
Monitoring of Influenza Virus
Susceptibility to Neuraminidase
Inhibitors (NAIs)
LV Gubareva, VM Deyde, X Xu, RA Bright
*, TG Sheu, AI Klimov

Influenza Division, National Center for Immunization and Respiratory Diseases,
Centers for Disease Control and Prevention, Atlanta Georgia, USA

*Present address:
Novavax, One Taft Court, Suite 200 Rockville, Maryland 20850 USA

Oseltamivir and zanamivir are currently approved NAIs for
the control of influenza infections; a third drug, peramivir, is
undergoing clinical evaluation. NAI-susceptibility is commonly
assessed through an enzyme activity inhibition assay with either
chemiluminogenic or fluorogenic substrate. Standardization
of assay conditions is essential for reliable drug resistance
monitoring. As a part of continued influenza strain surveillance,
we utilized a recently developed NAStar kit for the detection
of NAI-resistant mutants by means of chemiluminescence.
Zanamivir and oseltamivir were used to determine IC

50 values
for 133 A(H1N1), 186 A(H3N2), and 118 B viruses collected in
2005-2007. All viruses appeared sensitive to both drugs with
one exception. An influenza B virus, with a R371K substitution
at the enzyme active site, exhibited elevated IC50 values when
tested with both zanamivir (~150nM) and oseltamivir (~1,000
nM), which indicates drug resistance. Another influenza B
virus, although sensitive to both drugs, contained substitution
H274Y in the NA active site, which was previously shown to
confer in-vitro resistance to peramivir. The two newly identified
variants and a panel of well-characterized oseltamivir- or
zanamivir-selected mutants and their respective wild types
(WT) were then tested with four NAIs (oseltamivir, zanamivir,
peramivir, and A-315675). When tested with oseltamivir, the
oseltamivir-selected mutants [e.g., H274Y(N1)] exhibited 10-
fold or greater IC50 values than their WT. In contrast, a majority
of the zanamivir-resistant viruses [e.g., E119G(N2)] had <10-
fold increase in IC50 values compared to their WT, when tested
with zanamivir. Nevertheless, when tested with oseltamivir,
two of those mutants [R152K(B) and R292K(N2)] exhibited >10-
fold increase in their IC50 values compared to their WT viruses.
The H274Y(B) variant exhibited a 4-fold increase in IC50 value
for peramivir compared to that of the control virus. When the
same variant was tested in fluorescent assay, increase in IC50

values was greater for both peramivir (~10-fold) and oseltamivir
(~5-fold). The R371K variant exhibited cross-resistance to all
four NAIs in both assays (≥10 fold). A majority of NAI-resistant
mutants were detected with NAStar kit; thus, it could be
useful for drug resistance surveillance. To ensure dependable
detection of every zanamivir- and peramivir-resistant mutant,

improvements to the kit should be considered.

**HenryN** · July 23, 2008, 07:25 AM

Re: _|ANTIVIRAL RESISTANCE BAFFLES SCIENTISTS|_

Q136R abstract

Abstract O67
Novel Mutations in the ?150-Cavity?
of N1 Neuraminidase Confer Reduced
Sensitivity to the Neuraminidase Inhibitors
Aeron C Hurt
1,2, Ian G Barr1,2

1

World Health Organisation Collaborating Centre for Reference and Research on
Influenza, Parkville, Victoria 3052, Australia; 2Monash University, School of Applied
Sciences, Churchill, Victoria 3842, Australia

The neuraminidase (NA) inhibitors are a specifically designed
class of antiviral drugs that bind to the active site of the NA
surface glycoprotein of newly formed influenza virus particles
and prevent their efficient release from the host cell. Although
resistance to these inhibitors is relatively rare, investigation
of circulating strains for changes in susceptibility remains
important. Analysis of recent influenza isolates received at
the WHO Collaborating Centre for Influenza in Melbourne has
revealed four A(H1N1) strains with increased IC

50 (50% inhibitory
concentration) values to either zanamivir or oseltamivir
carboxylate. These isolates were received from locations
where little or no NA inhibitors were in use and are therefore
assumed to be derived from patients not being treated with
the NA inhibitors. Two of the strains, which demonstrated a
250-fold increase in zanamivir IC50 but no change in oseltamivir
carboxylate IC50, were found to have a Q136K mutation in the
NA gene, while a third strain which had a 30-fold increase in
zanamivir IC50 and no change in oseltamivir carboxylate IC50

was found to have a K150T mutation in the NA gene. The fourth
A(H1N1) virus identified to confer reduced sensitivity to the NA
inhibitors, had a 30-fold increase in zanamivir IC

50 and a 10-fold
change in oseltamivir carboxylate IC50 and was found to have a
K143R NA gene mutation. Interestingly, all of the four mutants
contained substitutions at residues located in and around
the recently identified ?150-cavity? (Russell et al, 2006), which
following x-ray crystallography was shown to be adjacent to
the NA active site of group-1 neuraminidases (N1, N4, N5, N8),
but is not present in group-2 neuraminidases (N2,N3,N6,N7,N9).
None of these sites has previously been identified as conferring
NA inhibitor resistance either in vitro or in clinical studies. Given
that residues in this cavity appear to impact on zanamivir
sensitivity, and to a lesser extent oseltamivir sensitivity, it will
therefore be important to determine the extent to which both
H1N1 and highly pathogenic H5N1 viruses with mutations in

this region may be circulating.

**HenryN** · July 23, 2008, 07:27 AM

Re: _|ANTIVIRAL RESISTANCE BAFFLES SCIENTISTS|_

Abstract O69
Indonesian H5N1 Isolates Demonstrate
Decreased Sensitivity to Oseltamivir
JL McKimm-Breschkin
1, P Selleck2, T Usman3, M Johnson2

1

CSIRO Molecular and Health Technologies, Parkville, Australia; 2CSIRO Livestock
Industries, Geelong, Australia; 3Disease Investigation Centre, Yogjakarta, Indonesia

Two different strains of highly pathogenic H5N1 avian influenza
have been circulating since 2003. Clade 1 has been found in
Vietnam, Thailand, Cambodia, Laos and Malaysia. Clade 2
subsequently emerged and spread from China to Indonesia,
Europe and Africa in 2004-2005. Due to its systemic availability
oseltamivir is the drug of choice for treating infected humans.
We tested the drug sensitivity of NAs from eight H5N1 viruses
from 2004 from Vietnam, two from 2004 from Malaysia, six
from Cambodia from 2004, four from 2005 and six clade 2 2005
viruses from Indonesia. Viruses were isolated from chickens,
ducks, geese and quail. In the absence of a validated cell culture
assay the IC

50 measured in the MUNANA based NA enzyme
inhibition assay was used for measuring drug sensitivity. All
clade 1 and clade 2 viruses had a similar sensitivity to zanamivir
as the reference human H1N1 NA. Sensitivities of the NAs to
oseltamivir fell into three groups compared to the human H1N1
strain. The clade 1 isolates from 2004 were all more sensitive
to oseltamivir than the human H1N1 control. However the NAs
of the 2005 Cambodian viruses showed a 6-7 fold decrease
specifically in oseltamivir sensitivity compared to the 2004
Cambodian isolates. These 2005 isolates came from the same
area as one of the more sensitive 2004 isolates, suggesting
regional evolution had occurred. Of more concern was the
third group. The NAs from all the clade 2 2005 Indonesian
viruses demonstrated a 25-30-fold decrease in sensitivity
specifically to oseltamivir compared to the clade 1 viruses. This
decrease in sensitivity is even greater than that conferred by
the N294S recently detected in Egypt, known to be selected
for by oseltamivir treatment. There was no altered sensitivity
to a third inhibitor, 4-AminoNeu5Ac2en, which shares the
4-amino substitution with oseltamivir, but has the original
glycerol side chain at the 6? position. This indicates that the
altered binding of oseltamivir was due to altered interaction
with its hydrophobic pentyl ether group, thus explaining why

no altered binding to zanamivir was seen.

**tropical** · July 23, 2008, 07:37 AM

Re: _|ANTIVIRAL RESISTANCE BAFFLES SCIENTISTS|_

#152,....

Thank you Dr. Niman.

**miso** · July 23, 2008, 04:24 PM

Re: _|ANTIVIRAL RESISTANCE BAFFLES SCIENTISTS|_

Yes, thank you.

**HenryN** · July 26, 2008, 06:00 PM

Re: _|ANTIVIRAL RESISTANCE BAFFLES SCIENTISTS|_

H274Y in France

gb|EU551826.1| Influenza A virus (A/Paris/749/2007(H1N1)) neu... 40.1 0.040
gb|EU551824.1| Influenza A virus (A/Paris/847/2007(H1N1)) neu... 40.1 0.040
gb|EU551821.1| Influenza A virus (A/Paris/963/2008(H1N1)) neu... 40.1 0.040
gb|EU551815.1| Influenza A virus (A/Paris/577/2007(H1N1)) neu... 40.1 0.040
gb|EU551814.1| Influenza A virus (A/Paris/1157/2008(H1N1)) ne... 40.1 0.040
gb|EU551813.1| Influenza A virus (A/Paris/1208/2008(H1N1)) ne... 40.1 0.040
gb|EU551812.1| Influenza A virus (A/Paris/1154/2008(H1N1)) ne... 40.1 0.040
gb|EU551811.1| Influenza A virus (A/Paris/341/2007(H1N1)) neu... 40.1 0.040
gb|EU551810.1| Influenza A virus (A/Paris/910/2007(H1N1)) neu... 40.1 0.040
gb|EU551809.1| Influenza A virus (A/Paris/644/2007(H1N1)) neu... 40.1 0.040

**HenryN** · July 27, 2008, 12:40 AM

Re: _|ANTIVIRAL RESISTANCE BAFFLES SCIENTISTS|_

A/Paris/963/2008 matches Hawaii

**HenryN** · July 27, 2008, 08:18 PM

Re: _|ANTIVIRAL RESISTANCE BAFFLES SCIENTISTS|_

Originally posted by niman View Post

A/Paris/963/2008 matches Hawaii

Below is the travel log linking the movement of H274Y from New Caledonia (red bold) to Brisbane (blue bold)

gb|EU551821.1| Influenza A virus (A/Paris/963/2008(H1N1)) neu... 36.2 0.62
gb|EU716580.1| Influenza A virus (A/Florida/02/2008(H1N1)) se... 36.2 0.62
gb|EU516125.1| Influenza A virus (A/Hawaii/28/2007(H1N1)) seg... 36.2 0.62
gb|EU516123.1| Influenza A virus (A/Hawaii/28/2007(H1N1)) seg... 36.2 0.62
gb|EU516112.1| Influenza A virus (A/Hawaii/21/2007(H1N1)) seg... 36.2 0.62
gb|EU516141.1| Influenza A virus (A/Minnesota/23/2007(H1N1)) ... 36.2 0.62
gb|EU516028.1| Influenza A virus (A/Massachusetts/05/2007(H1N... 36.2 0.62
gb|EU516027.1| Influenza A virus (A/Texas/31/2007(H1N1)) segm... 36.2 0.62
gb|CY027037.1| Influenza A virus (A/Kansas/UR06-0104/2007(H1N... 36.2 0.62
gb|EU516199.1| Influenza A virus (A/Georgia/20/2006(H1N1)) se... 36.2 0.62
gb|EU516198.1| Influenza A virus (A/Georgia/20/2006(H1N1)) se... 36.2 0.62
gb|EU516197.1| Influenza A virus (A/Georgia/20/2006(H1N1)) se... 36.2 0.62

**HenryN** · November 17, 2008, 09:13 AM

Re: _|ANTIVIRAL RESISTANCE BAFFLES SCIENTISTS|_

New phylogenetic tree from Japan

http://idsc.nih.go.jp/iasr/rapid/graph/pf34623.pdf

**HenryN** · November 17, 2008, 10:51 AM

Re: _|ANTIVIRAL RESISTANCE BAFFLES SCIENTISTS|_

Preliminary> influenza (A/H1N1) oseltamivir-resistant strain (H275Y <SUP>*)</SUP> occur in the domestic situation [second report]

はじめに

First

2007年11月頃から、ノイラミニダーゼ（NA）蛋白質の275番目のアミノ酸がヒスチジンからチロシン（H275Y <SUP>*</SUP> ）に置換し、オセルタミビルに対して強い耐性となるA/H1N1亜型インフルエンザウイルスが、ノルウェーの67％を筆頭に、EU諸国全体では20％以上の高頻度で検出されるようになった1)。

11 around 2007, neuraminidase (NA) 275 proteins from the second histidine tylosin amino acids (H275Y <SUP>*)</SUP> to replace the strong resistance to oseltamivir for influenza A/H1N1 virus subtype, and 67 percent in Norway Led, EU countries, more than 20 percent of the overall high-frequency has to be found in 1).

このため、WHOグローバルインフルエンザサーベイランスネットワークでは、全世界的なNA阻害剤（NAI ）耐性株サーベイランスを強化し、各国における耐性株出現状況を報告するように要請した。

For this reason, WHO GUROBARUINFURUENZASABEIRANSUNETTOWAKU the global NA inhibitor (NAI) to strengthen surveillance-resistant strain, resistant strain emerged in the country to report the situation said.

これを受けて世界各国から週単位または月単位で情報が寄せられ、それらの集計結果は定期的にWHOのホームページ（HP）に掲載されるようになった2）。

This was the week or month from around the world have information in their units, their results of the WHO website on a regular basis (HP) came to be published in the 2).

2008年4月～10月現在での世界全体の出現頻度は39％であり、2007年後半～今年3月までの16％を大きく上回り、南半球諸国を含めて世界的に耐性株が広がり始めている。

April-October 2008 of the current frequency in the entire world is 39 percent, from late 2007 until March of this year's 16 percent larger than the Southern Hemisphere countries in the world, including the resistant strain is starting to spread .

特に、セネガル、南アフリカではA/H1N1分離株の100％が耐性であり、アフリカ地域全体でも88％が耐性株となっている2）。

In particular, Senegal, South Africa A/H1N1 isolate the resistance of 100 percent and 88 percent in Africa but the entire region is a two-resistant strain).

これら耐性株はオセルタミビルを服用していない患者から分離されており、通常の病原性をもった市中流行株として人々の間に広がっており3)、インフルエンザ対策上大きな問題となっている。

These shares oseltamivir resistance is not taking patients have been isolated from the normal trend of the market share with virulence as the spread between people, and 3), the flu is a big problem.

一方、わが国は世界のオセルタミビル生産量の70％以上を臨床現場で使用していることから、市中流行の耐性株に加えて、薬剤の選択圧による耐性株の高頻度出現が危惧され、世界中がわが国における耐性株の発生動向を注目している。

Meanwhile, the country of the world's production of oseltamivir for more than 70 percent have clinical use in the field, because in addition to the market trend-resistant strain of the selective pressure of drug-resistant strain of the emergence of high-frequency危惧SA of the world Shares in the incidence of resistance in the country are watching developments.

このような背景から、国立感染症研究所（感染研）では地方衛生研究所（地研）の協力を得て、2 007/08シーズンに国内で分離されたA/H1N1株に対する耐性株緊急サーベイランスを実施することとした。

Against this background, the National Institute of Infectious Diseases (lab infection), the local Public Health Research Institute (research areas) with the cooperation of the 2007/08 season, A/H1N1 strain isolated in the country for emergency surveillance-resistant strain To be implemented.

わが国における緊急サーベイランスの経過報告は、第1報としてIASR 6月号に掲載されているが4）、今回は、それ以降に追加された分離株の解析結果を含む2007/08シーズン分離株の総まとめとして第2報で報告する。

The progress report in Japan that an emergency surveillance, as the first report on the issue IASR 6 is 4), this time, was later added to isolate the analysis results of the 2007/08 season, including the separation of the total shares As reported in the second report together.

（*）各種論文ではH274Yの表記をしているが、これは、H3N2亜型ウイルスのNA蛋白質のアミノ酸番号をもとにした表記法(N2表記法)であり、H1N1のNA蛋白質の場合は、耐性マーカーのアミノ酸番号はメチオニンから数えて275番目となる。

(*)'s H274Y in the various papers have representation, which, H3N2 subtype of the virus NA proteins, amino acids were based on the number notation (N2 notation) and, H1N1 cases in the NA protein , A marker of resistance from the amino acid methionine number at 275 and counting.

よって、本文では耐性マーカーのアミノ酸番号をH275Yで統一する。

Thus, the amino acids in the body and a number of resistance markers in a unified H275Y.

1. 日本国内の耐性株発生状況
今回の耐性株緊急サーベイランスに協力が得られた地研から寄せられた耐性株検出状況を都道府県別に表1 (pdf)に示した（耐性ウイルスの検出法はIASR 6月号第1報の方法の項を参照）4)。

1. Occur the domestic situation
-resistant strain of the emergency-resistant strain of surveillance research obtained in the cooperation received from the State-resistant strain detected by the situation in Table 1 (pdf) to the (virus-resistant The detection method IASR 6 issue the first report of the methods section) 4).

総解析数1,734株中45株の耐性株が同定され、国内の耐性株の発生頻度は2.6％であった（表1 ）。

Analysis of 1734 total number of shares of stock during the 45-resistant strain is identified, the frequency of domestic-resistant strain was 2.6 percent (Table 1).

発生頻度を年別に見ると、2007年は331株中1株（0.3%）、2008年は1,403株中44株（3 .1%）で、2008年に入ってからの発生頻度が高かった。

Past look at the frequency incidence, and in 2007 the 331 shares per share (0.3 percent), while 44 stocks in 2008, 1403 shares (3.1 percent), since 2008 the incidence of high frequency.

しかしながら、わが国は世界一のオセルタミビル使用国にもかかわらず、諸外国に比べるとその発生頻度は著しく低かった。

However, our use of oseltamivir in the country in the world, despite Compared to other countries and their extremely low frequency.

耐性株が分離されたのは本州の10県であったが（図1 pdf）、鳥取県を除いた9県それぞれでの発生頻度は、1.2～7.3%であった。

-Resistant strain was isolated in the 10 prefectures of Honshu (Figure 1 pdf), Tottori Prefecture, which excludes often occur in nine prefectures, respectively, from 1.2 to 7.3 percent.

一方、鳥取県では68株中22株が耐性株で、発生頻度は32.4％と突出していた（図1 ）。

Meanwhile, shares in Tottori Prefecture during the 22 stocks in the 68-resistant strain, the frequency has been outstanding and 32.4 percent (Figure 1).

これら耐性株の発生状況を市町村別に見ると（図2 pdf）、鳥取市を中心とした県東部から１月下旬に多く分離された株は、NA遺伝子系統樹上ハワイ系統(系統樹解析の項参照)に属していたが、２～３月の分離株は北欧系統に入るものもあり、両系統が混在していた。

These state-resistant strain occurred in the city and another (Figure 2 pdf), with a focus on the city of Tottori Prefecture in late January from the eastern most isolated stocks, NA Hawaii strain on the genetic family tree (the term analysis of the evolutionary tree ) Belongs to, but separate shares in February and March into the Nordic some strains, the two strains were mixed.

一方、倉吉市を中心とした県中部からは、２～３月に耐性株が多く分離され、それらは北欧系統に属していた。

On the other hand, with a focus on Kurayoshi from the central prefecture, February and March are resistant to the separation of stocks, they belong to the Nordic system.

このことから鳥取県では県東部、県中部で遺伝的に異なる２つの系統の耐性株が広く流行していたことが示唆された。

From the eastern part of Tottori Prefecture, the prefectural government, in the central prefecture of two different genetic strains resistant strain of the epidemic have been widely suggested.

鳥取県内でこれほど耐性株が流行していたにもかかわらず、近隣県の発生頻度が高くないのは、当該県での耐性株感染者は低年齢層が多かったため、県を越えた移動が少なかったことが原因のひとつと考えられる。

In Tottori Prefecture, the so-resistant strain was prevalent, despite the high frequency of the neighboring prefecture of the resistant strain of the infected people in the province are low due to age, moving beyond the County One of the few considered to be the cause.

2. 系統樹解析

2. Phylogenetic tree analysis

2007/08シーズンに流行したA/H1N1インフルエンザウイルスは、NA遺伝子の系統樹上でサブクレード２Ｂ（アミノ酸マーカー：H45N 、G249K、T287I、K329E、G354D）およびサブクレード２Ｃ（アミノ酸マーカー：S82P 、M188I、I267M、L367I、V393I、T453I）に分かれる[ 図３ :左上 (pdf)]。

Prevalent in the 2007/08 season, influenza A/H1N1 virus, NA SABUKUREDO on the evolutionary tree of a gene 2B (amino acid marker: H45N, G249K, T287I, K329E, G354D) and SABUKUREDO 2C (amino acid marker: S82P, M188I, I267M, L367I, V393I, T453I) into the Figure 3: upper left corner (pdf)].

国内外の耐性株のほとんどすべては今期ワクチン株のA/ブリスベン/59/2007を含むサブクレード２Ｂに属していた。

Most of the foreign-resistant strain of the vaccine strain of the season for all A / Brisbane / 59/2007, including SABUKUREDO belongs to 2B.

サブクレード２Ｂ内ではさらに２つの系統に別れ、D354Gのマーカーを持ち世界中で広く分離されている北欧系統の耐性株と、このマーカーを持たないワクチン株A/ブリスベン/59/2007を含むハワイ系統の耐性株に分けられた。

2B SABUKUREDO two more within goodbye to the strains, D354G marker in the world and are widely separated Scandinavian-resistant strains of the shares, the markers do not have a vaccine strain A / Brisbane / 59/2007, including strains of Hawaii Resistance was divided into shares.

ハワイ系統の耐性株は分離株数から見ると世界的には少数派である。

Shares of Hawaiian-resistant strains isolated from the number of shares and the world is in the minority.

わが国で分離された耐性株は、ハワイ系統に属するものが多く認められたが、横浜市、鳥取県および岡山県からの耐性株は北欧系統に属するものも検出されている。

-Resistant strain isolated in Japan, Hawaii, a lot of strain was recognized as belonging to the city of Yokohama, Tottori and Okayama prefectures from belonging to resistant strains of the Nordic stock is also detected.

一方、2007年11月に横浜市で分離された一株（A/横浜/91/2007株）は、サブクレード２Ｃに属していた。

Meanwhile, in November 2007 and separated in the city of Yokohama shares (A / Yokohama / 91/2007), belongs to 2C SABUKUREDO.

3. 抗原解析

3. Antigenic analysis

15株の国内耐性株について、新旧ワクチン株およびその類似株に対するフェレット参照抗血清を用いた赤血球凝集抑制（ＨＩ）試験で抗原解析を実施した結果、国内で分離されたハワイ系統および北欧系統いずれの耐性株も、今期のワクチン株A/ブリスベン/59/2007類似株であった (IASR 6月号、第1報参照) 4)。

15 shares for shares in the resistance, and its share of old and new vaccine for ferrets to see a similar line with anti-serum hemagglutination inhibition (HI) test was conducted to analyze the results of antigen in the country and Nordic strains isolated strains either Hawaii -Resistant strain, the current term of the vaccine strain A / Brisbane / 59/2007 shares were similar (IASR 6 issue, the first report) 4).

このことから、これら耐性株に対して、今冬のワクチンは有効であることが示唆された。

For this reason, these stocks resistant to the vaccine this winter suggested that to be effective.

4. 薬剤感受性

4. Chemosensitivity

2007/08シーズンに分離された薬剤感受性株240株（表１：青字）に対するNAI薬剤感受性試験の結果、薬剤感受性株のオセルタミビルに対する50％NA活性阻害濃度（IC50）の平均値は0.09nMであった。

The separation of the 2007/08 season, 240 shares drug-sensitive stocks (Table 1: blue) drug susceptibility testing for the NAI as a result of the drug oseltamivir-sensitive shares, 50% NA activity inhibition concentration (IC50) in the average value of the 0.09nM .

一方、国内耐性株のオセルタミビルに対するIC50値は、おおむね30.0nM以上を示し、薬剤感受性株に比べて300倍以上もオセルタミビルに対して感受性が低下していた。

On the other hand, domestic resistance to oseltamivir IC50 value of the shares, or more generally indicates 30.0nM, drug-sensitive shares compared to 300 times more sensitive to oseltamivir also has been slow.

これらの耐性株のほとんどすべてはザナミビルに対しては感受性であったが、鳥取県で分離された１株（A/鳥取/44/2008）はオセルタミビル、ザナミビル両方に耐性であった。

These Zanamivir-resistant strain to the most sensitive of all, but isolated in Tottori Prefecture per share (A / Tottori / 44/2008), oseltamivir, was resistant to both Zanamivir.

また、別の1株（A/鳥取/16/2008）は、ザナミビルに耐性であった（表２）。

Another per share (A / Tottori / 16/2008), was resistant to Zanamivir (Table 2).

一方、クレード２Cに属する横浜市の分離株（A/横浜/91/2007）は、NAIとは別の作用機序を持つ抗インフルエンザウイルス薬のアマンタジンに対する耐性マーカー（M2タンパク質のS31N）をもち、オセルタミビルとアマンタジンの2剤耐性と考えられた。

On the other hand, belong to the clade Yokohama 2C isolate (A / Yokohama / 91/2007), NAI is a different mechanism of action of anti-flu drug amantadine resistance to the virus marker (M2 protein S31N) and Life Oseltamivir and amantadine-resistant and 2.

５. A/H3N2およびB型インフルエンザウイルスに対するNAI耐性株サーベイランス
感染研ではNAI耐性株サーベイランスとして、A/H3N2およびB型インフルエンザウイルスについても、全長のNA遺伝子解析およびNAI薬剤感受性試験を平行して実施している。

5. A/H3N2 and B-NAI-resistant strain of influenza virus infection surveillance
surveillance research for the NAI-resistant strain, A/H3N2 and B-type influenza viruses, the total length of the NA gene analysis and drug susceptibility testing parallel NAI Are carried out.

表２は、A/H1N1株に加えて2007/08シーズンに国内で分離されたA/H3N2とB型株における耐性株検出状況をまとめたものである。

Table 2, A/H1N1 in addition to the shares in the separation of the 2007/08 season, A/H3N2 and B-type strain was resistant strain found in the summarize the situation.

A/H3N2（89株）およびB型（78株）についてはオセルタミビルおよびザナミビルに対して明確な耐性を示す株は見つからなかった。

A/H3N2 (89 shares) and type B (78 shares) and Zanamivir for oseltamivir resistance is indicating clearly that found no shares.

おわりに

Conclusion

2007/08シーズンA/H1N1分離株に対する今回の薬剤耐性株緊急サーベイランスにより、わが国での耐性株の発生頻度は海外諸国に比べて低く、今のところEU諸国、アフリカ諸国、豪州のような深刻な状態になっていない。

For the 2007/08 season, A/H1N1 isolate emergency surveillance of the drug-resistant strain, resistant strain of the outbreak in Japan is often lower than in foreign countries, EU countries so far, African countries, like Australia, serious Is not ready.

また、A/H3N2およびB型インフルエンザウイルスに対する耐性株は確認されておらず、今のところ国内におけるオセルタミビルによるインフルエンザの治療方針に大きな影響はないと思われる。

In addition, A/H3N2 and B-resistant strain of the flu virus had not been confirmed so far in the domestic policies oseltamivir in the treatment of influenza will not be a big influence.

また、今回分離された国内耐性株は今季のワクチン株A/ブリスベン/59/2007に遺伝的にも抗原的にも類似しているため、ワクチンは有効であると考えられる。

In addition, the separation of the domestic season-resistant strain of the vaccine strain A / Brisbane / 59/2007 on the genetic and antigenic are similar, the vaccine is believed to be valid.

これに加えて、2株の例外はあるが、耐性株のほとんどすべてはザナミビルに対しては感受性であることから、ザナミビルによる治療も有効である。

In addition, the two share some exceptions, almost all of the Zanamivir-resistant strain that is sensitive, and effective treatment with Zanamivir.

これまでも、NA阻害剤耐性株はA/H1N1、A/H3N2およびB型インフルエンザウイルスで低頻度（0.11～0.68％）ながら見つかってきたが（IA SR 6月号、第1報、表１）4）、これらは市中流行株としてヒトからヒトへ伝播拡大することはなく、自然消滅していた。

So far, NA stock inhibitor-resistant A/H1N1, A/H3N2 and B-type influenza virus in the low-frequency (0.11 to 0.68%) have been found and (IASR 6 issue, the First Report, Table 1) 4 ), Which shares the market as a fashion spread from human to human, not to expand natural been extinguished.

しかし、今回諸外国で見つかっているオセルタミビル耐性株は市中流行株と変わらぬ伝播能力を持ち、国によっては流行の主流になっている。

However, other countries of the oseltamivir-resistant strain has been found in the continued transmission capacity and market share trends, and in some countries is becoming a major epidemic.

わが国でも、理由は不明であるが、鳥取県で突出して高い発生頻度が観察され、今冬の全国的な流行拡大が心配される。

Japan also is not clear why the projection in Tottori Prefecture, and high frequency been observed, this winter to expand the nation feared an epidemic.

オセルタミビル耐性株は通常の感受性株と比べて臨床症状に違いは認められないが、オセルタミビルを多用しているわが国にとって、耐性株がアマンタジン耐性株のように流行株の主流になった場合は、本薬剤による治療方針に大きな影響をもたらすことになる。

Shares of oseltamivir resistance than normal-sensitive stocks and can not accept the differences in clinical symptoms, but then Oseltamivir is a lot for our country, shares of resistance to amantadine-resistant strain of If the epidemic is in the mainstream of shares, Treatment with a drug policy will be a big impact.

臨床現場では、迅速診断キットによってA型またはB型の識別は可能であるが、A/H1とA/H3亜型の識別は不可能であることから、耐性株を排出している患者にもオセルタミビルを処方することにもなりかねない。

In the clinical field, and rapid diagnostic kit of the type A or B type is possible to identify, A/H1 and A/H3 subtype is impossible to identify the emission shares are resistant to the patient To prescribe oseltamivir could.

このことから、今冬の流行においても、A/H1N1株だけでなくA/H3N2およびB型インフルエンザウイルスを含めた全国レベルでの継続した監視が必要である。

Thus, even in winter fashions, A/H1N1 and B-shares as well as influenza A/H3N2 virus at the national level, including the need for continued monitoring.

1) http://ecdc.europa.eu/en/Health_topics/influenza/antivirals_graph.aspx (EU、EEA諸国の耐性株発生頻度)

1) http://ecdc.europa.eu/en/Health_topi...als_graph.aspx (EU, EEA countries, the frequency-resistant strain)

2) http://www.who.int/csr/disease/influenza/h1n1_table/en/index.html (各国の耐性株出現頻度速報)

2) http://www.who.int/csr/disease/influ.../en/index.html (frequency-resistant strain of international news)

3) http://www.who.int/csr/disease/influenza/oseltamivir_faqs/en/index.html (H275Y耐性株に関するFAQ)

3) http://www.who.int/csr/disease/influ.../en/index.html (H275Y-resistant strain on the FAQ)

4) IASR 29: 155-159, 2008 （インフルエンザA/H1N1オセルタミビル耐性株H275Y(*)の国内発生状況　[第1報])

4) IASR 29: 155-159, 2008 (oseltamivir-resistant strain A/H1N1 influenza H275Y (*) caused domestic First Report)

国立感染症研究所ウイルス第三部第一室インフルエンザ薬剤耐性株サーベイランスチーム製品評価技術基盤機構バイオテクノロジー本部ゲノム解析部門・インフルエンザウイルス遺伝子解析チーム全国地方衛生研究所

The Third National Institute of Infectious Diseases Department viral drug-resistant strain of influenza surveillance room team Biotechnology Institute of Technology and Evaluation Division headquarters influenza virus genome analysis of the local National Institutes of Health genetic analysis team

http://translate.google.com/translate?hl=en&sl=ja&u=http://idsc.nih.go.jp/iasr/rapid/pr3462.html&sa=X&oi=translate&resnum=1&ct=result&prev=/search%3Fq%3Dh275y%26hl%3Den%26lr%3D%26rls%3DTSHA,TSHA:2006-07,TSHA:en%26as_qdr%3Dd

<HR>http://idsc.nih.go.jp/iasr/rapid/pr3462.html

**HenryN** · November 18, 2008, 08:58 AM

Re: _|ANTIVIRAL RESISTANCE BAFFLES SCIENTISTS|_

Updated list with H274Y

gb|FJ445025.1| Influenza A virus (A/England/654/2007(H1N1)) s... 60.0 2e-07
gb|FJ445031.1| Influenza A virus (A/England/557/2007(H1N1)) s... 60.0 2e-07
gb|FJ445029.1| Influenza A virus (A/England/26/2008(H1N1)) se... 60.0 2e-07
gb|FJ445066.1| Influenza A virus (A/England/594/2006(H1N1)) s... 60.0 2e-07
gb|FJ445020.1| Influenza A virus (A/Netherlands/159/2008(H1N1... 60.0 2e-07
gb|FJ403587.1| Influenza A virus (A/Scotland/5/2007(H1N1)) se... 60.0 2e-07
gb|FJ403586.1| Influenza A virus (A/England/684/2007(H1N1)) s... 60.0 2e-07
gb|FJ403583.1| Influenza A virus (A/Denmark/27/2007(H1N1)) se... 60.0 2e-07
gb|FJ403582.1| Influenza A virus (A/Luxembourg/116/2008(H1N1)... 60.0 2e-07
gb|FJ403580.1| Influenza A virus (A/Austria/406109/2008(H1N1)... 60.0 2e-07
gb|FJ403575.1| Influenza A virus (A/Parma/34/08(H1N1)) segmen... 60.0 2e-07
gb|FJ403574.1| Influenza A virus (A/Geneva/9296/2008(H1N1)) s... 60.0 2e-07
gb|FJ403570.1| Influenza A virus (A/Canarias/RR-2915/2007(H1N... 60.0 2e-07
gb|FJ403568.1| Influenza A virus (A/Berlin/47/2008(H1N1)) seg... 60.0 2e-07
gb|FJ403563.1| Influenza A virus (A/Slovenia/123/2008(H1N1)) ... 60.0 2e-07
gb|FJ403562.1| Influenza A virus (A/Belgium/G257/08(H1N1)) se... 60.0 2e-07
gb|FJ403561.1| Influenza A virus (A/Kiev/313/2008(H1N1)) segm... 60.0 2e-07
gb|FJ403558.1| Influenza A virus (A/Lisbon/3/2008(H1N1)) segm... 60.0 2e-07
gb|FJ403555.1| Influenza A virus (A/Lyon/1337/07(H1N1)) segme... 60.0 2e-07
gb|FJ403554.1| Influenza A virus (A/Athens/41/2008(H1N1)) seg... 60.0 2e-07
gb|FJ403550.1| Influenza A virus (A/Norway/1736/2007(H1N1)) s... 60.0 2e-07
gb|FJ403548.1| Influenza A virus (A/Bucuresti/229/2008(H1N1))... 60.0 2e-07
gb|FJ380948.1| Influenza A virus (A/Finland/11/2008(H1N1)) se... 60.0 2e-07
dbj|AB465343.1| Influenza A virus (A/Leiden/07120/2008(H1N1))... 60.0 2e-07
dbj|AB465342.1| Influenza A virus (A/Leiden/00822/2008(H1N1))... 60.0 2e-07
gb|FJ360527.1| Influenza A virus (A/Ireland/69/2008(H1N1)) se... 60.0 2e-07
gb|FJ360526.1| Influenza A virus (A/Ireland/68/2008(H1N1)) se... 60.0 2e-07
gb|FJ360525.1| Influenza A virus (A/Ireland/24/2008(H1N1)) se... 60.0 2e-07
gb|FJ360524.1| Influenza A virus (A/Ireland/27/2008(H1N1)) se... 60.0 2e-07
gb|FJ360523.1| Influenza A virus (A/Ireland/43/2008(N1)) segm... 60.0 2e-07
dbj|AB462372.1| Influenza A virus (A/Leiden/13892/2008(H1N1))... 60.0 2e-07
dbj|AB462371.1| Influenza A virus (A/Leiden/12178/2008(H1N1))... 60.0 2e-07
dbj|AB462370.1| Influenza A virus (A/Leiden/11693/2008(H1N1))... 60.0 2e-07
emb|FM174468.1| Influenza A virus (A/Luxembourg/456/2008(H1N1... 60.0 2e-07
emb|FM174467.1| Influenza A virus (A/Luxembourg/421/2008(H1N1... 60.0 2e-07
emb|FM174466.1| Influenza A virus (A/Luxembourg/402/2008(H1N1... 60.0 2e-07
emb|FM174465.1| Influenza A virus (A/Luxembourg/382/2008(H1N1... 60.0 2e-07
emb|FM174464.1| Influenza A virus (A/Luxembourg/373/2008(H1N1... 60.0 2e-07
emb|FM174463.1| Influenza A virus (A/Luxembourg/285/2008(H1N1... 60.0 2e-07
emb|FM174462.1| Influenza A virus (A/Luxembourg/278/2008(H1N1... 60.0 2e-07
emb|FM174461.1| Influenza A virus (A/Luxembourg/273/2008(H1N1... 60.0 2e-07
emb|FM174460.1| Influenza A virus (A/Luxembourg/265/2008(H1N1... 60.0 2e-07
emb|FM174458.1| Influenza A virus (A/Luxembourg/215/2008(H1N1... 60.0 2e-07
emb|FM174457.1| Influenza A virus (A/Luxembourg/187/2008(H1N1... 60.0 2e-07
emb|FM174456.1| Influenza A virus (A/Luxembourg/182/2008(H1N1... 60.0 2e-07
emb|FM174455.1| Influenza A virus (A/Luxembourg/132/2008(H1N1... 60.0 2e-07
emb|FM174453.1| Influenza A virus (A/Luxembourg/164/2008(H1N1... 60.0 2e-07
emb|FM174430.1| Influenza A virus (A/Luxembourg/022/2008(H1N1... 60.0 2e-07
emb|FM174428.1| Influenza A virus (A/Luxembourg/019/2008(H1N1... 60.0 2e-07
emb|FM174427.1| Influenza A virus (A/Luxembourg/016/2008(H1N1... 60.0 2e-07
emb|FM174426.1| Influenza A virus (A/Luxembourg/006/2008(H1N1... 60.0 2e-07
emb|FM174425.1| Influenza A virus (A/Luxembourg/098/2008(H1N1... 60.0 2e-07
emb|FM174424.1| Influenza A virus (A/Luxembourg/090/2008(H1N1... 60.0 2e-07
emb|FM174423.1| Influenza A virus (A/Luxembourg/086/2008(H1N1... 60.0 2e-07
emb|FM174420.1| Influenza A virus (A/Luxembourg/286/2008(H1N1... 60.0 2e-07
emb|FM174419.1| Influenza A virus (A/Luxembourg/279/2008(H1N1... 60.0 2e-07
emb|FM174418.1| Influenza A virus (A/Luxembourg/261/2008(H1N1... 60.0 2e-07
emb|FM174416.1| Influenza A virus (A/Luxembourg/249/2008(H1N1... 60.0 2e-07
emb|FM174415.1| Influenza A virus (A/Luxembourg/234/2008(H1N1... 60.0 2e-07
emb|FM174414.1| Influenza A virus (A/Luxembourg/222/2008(H1N1... 60.0 2e-07
emb|FM174411.1| Influenza A virus (A/Luxembourg/176/2008(H1N1... 60.0 2e-07
emb|FM174407.1| Influenza A virus (A/Luxembourg/116/2008(H1N1... 60.0 2e-07
emb|FM174406.1| Influenza A virus (A/Luxembourg/115/2008(H1N1... 60.0 2e-07
gb|FJ227687.1| Influenza A virus (A/HongKong/942/2008(H1N1)) ... 60.0 2e-07
gb|FJ179363.1| Influenza A virus (A/Illinois/15/2007(H1N1)) s... 60.0 2e-07
gb|FJ179362.1| Influenza A virus (A/Illinois/16/2007(H1N1)) s... 60.0 2e-07
gb|FJ179361.1| Influenza A virus (A/Pennsylvania/13/2007(H1N1... 60.0 2e-07
gb|EU914908.1| Influenza A virus (A/Johannesburg/45/2008(H1N1... 60.0 2e-07
gb|EU914907.1| Influenza A virus (A/Johannesburg/36/2008(H1N1... 60.0 2e-07
gb|EU914906.1| Influenza A virus (A/Johannesburg/35/2008(H1N1... 60.0 2e-07
gb|EU914905.1| Influenza A virus (A/Johannesburg/33/2008(H1N1... 60.0 2e-07
gb|EU914904.1| Influenza A virus (A/Johannesburg/14/2008(H1N1... 60.0 2e-07
gb|EU914903.1| Influenza A virus (A/Johannesburg/21/2008(H1N1... 60.0 2e-07
gb|EU914902.1| Influenza A virus (A/CapeTown/26/2008(H1N1)) n... 60.0 2e-07
gb|EU914901.1| Influenza A virus (A/Johannesburg/12/2008(H1N1... 60.0 2e-07
gb|EU685788.1| Influenza A virus (A/Paris/1170/2008(H1N1)) ne... 60.0 2e-07
gb|EU551826.1| Influenza A virus (A/Paris/749/2007(H1N1)) neu... 60.0 2e-07
gb|EU551824.1| Influenza A virus (A/Paris/847/2007(H1N1)) neu... 60.0 2e-07
gb|EU551821.1| Influenza A virus (A/Paris/963/2008(H1N1)) neu... 60.0 2e-07
gb|EU551815.1| Influenza A virus (A/Paris/577/2007(H1N1)) neu... 60.0 2e-07
gb|EU551814.1| Influenza A virus (A/Paris/1157/2008(H1N1)) ne... 60.0 2e-07
gb|EU551813.1| Influenza A virus (A/Paris/1208/2008(H1N1)) ne... 60.0 2e-07
gb|EU551812.1| Influenza A virus (A/Paris/1154/2008(H1N1)) ne... 60.0 2e-07
gb|EU551811.1| Influenza A virus (A/Paris/341/2007(H1N1)) neu... 60.0 2e-07
gb|EU551810.1| Influenza A virus (A/Paris/910/2007(H1N1)) neu... 60.0 2e-07
gb|EU551809.1| Influenza A virus (A/Paris/644/2007(H1N1)) neu... 60.0 2e-07
gb|EU887035.1| Influenza A virus (A/South Carolina/01/2008(H1... 60.0 2e-07
gb|EU851986.1| Influenza A virus (A/Minnesota/01/2008(H1N1)) ... 60.0 2e-07
gb|EU851982.1| Influenza A virus (A/Hawaii/02/2008(H1N1)) seg... 60.0 2e-07
gb|EU851980.1| Influenza A virus (A/Hawaii/01/2008(H1N1)) seg... 60.0 2e-07
gb|EU779650.1| Influenza A virus (A/North Carolina/02/2008(H1... 60.0 2e-07
gb|EU779643.1| Influenza A virus (A/New Jersey/10/2008(H1N1))... 60.0 2e-07
gb|EU779641.1| Influenza A virus (A/Memphis/03/2008(H1N1)) ne... 60.0 2e-07
gb|EU681266.1| Influenza A virus (A/Bursa-TR/1231/2007(H1N1))... 60.0 2e-07
gb|EU681265.1| Influenza A virus (A/Istanbul-TR/1219/2007(H1N... 60.0 2e-07
gb|EU681264.1| Influenza A virus (A/Istanbul-TR/1198/2007(H1N... 60.0 2e-07
gb|EU681263.1| Influenza A virus (A/Ankara-TR/170/2008(H1N1))... 60.0 2e-07
gb|EU681262.1| Influenza A virus (A/Istanbul-TR/111/2008(H1N1... 60.0 2e-07
gb|EU702755.1| Influenza A virus (A/Hong Kong/17/2008(H1N1)) ... 60.0 2e-07
gb|EU716587.1| Influenza A virus (A/Washington/01/2008(H1N1))... 60.0 2e-07
gb|EU716580.1| Influenza A virus (A/Florida/02/2008(H1N1)) se... 60.0 2e-07
gb|EU624316.1| Influenza A virus (A/England/557/2007(H1N1)) s... 60.0 2e-07
gb|EU570806.1| Influenza A virus (A/Bursa-TR/28/2008(H1N1)) n... 60.0 2e-07
gb|EU567014.1| Influenza A virus (A/New Jersey/06/2008(H1N1))... 60.0 2e-07
gb|EU567009.1| Influenza A virus (A/Arizona/13/2007(H1N1)) se... 60.0 2e-07
gb|EU567006.1| Influenza A virus (A/Arizona/14/2007(H1N1)) se... 60.0 2e-07
gb|EU566999.1| Influenza A virus (A/Wisconsin/01/2008(H1N1)) ... 60.0 2e-07
gb|EU566998.1| Influenza A virus (A/Maryland/04/2007(H1N1)) s... 60.0 2e-07
gb|EU566987.1| Influenza A virus (A/New Jersey/20/2007(H1N1))... 60.0 2e-07
gb|EU566983.1| Influenza A virus (A/New Jersey/05/2008(H1N1))... 60.0 2e-07
gb|EU566977.1| Influenza A virus (A/Pennsylvania/02/2008(H1N1... 60.0 2e-07
gb|EU566968.1| Influenza A virus (A/Arizona/15/2007(H1N1)) se... 60.0 2e-07
gb|EU516201.1| Influenza A virus (A/New Jersey/16/2007(H1N1))... 60.0 2e-07
gb|EU516200.1| Influenza A virus (A/Illinois/10/2007(H1N1)) s... 60.0 2e-07
gb|EU516196.1| Influenza A virus (A/Arizona/03/2007(H1N1)) se... 60.0 2e-07
gb|EU516148.1| Influenza A virus (A/New Jersey/15/2007(H1N1))... 60.0 2e-07
gb|EU516125.1| Influenza A virus (A/Hawaii/28/2007(H1N1)) seg... 60.0 2e-07
gb|EU516123.1| Influenza A virus (A/Hawaii/28/2007(H1N1)) seg... 60.0 2e-07
gb|EU516112.1| Influenza A virus (A/Hawaii/21/2007(H1N1)) seg... 60.0 2e-07
gb|EU879082.1| Influenza A virus (A/Zhejiang/Xiangshan522/200... 58.0 1e-06
gb|EU879064.1| Influenza A virus (A/Gansu/Chenguan/1129/2007(... 58.0 1e-06

**HenryN** · November 18, 2008, 09:05 AM

Re: _|ANTIVIRAL RESISTANCE BAFFLES SCIENTISTS|_

<TABLE cellSpacing=0 cellPadding=0 width="100%" border=0><TBODY><TR><TD class=content><TABLE cellSpacing=0 cellPadding=0 width="100%" border=0><TBODY><TR title="Click on column header to change the sort order"><TD class=viewDataBorderTBRBold>Country</TD><TD class=viewDataBorderBold>Subgroup</TD><TD class=viewDataBorderBold align=middle>Period</TD><TD class=viewDataBorderBold align=middle>Year</TD><TD class=viewDataBorderBold align=middle>Value</TD><TD class=viewDataBorderBold align=middle>Source</TD></TR><TR><TD class=categoryPath align=middle colSpan=7>Communicable Diseases -> Influenza -> Influenza viruses detected</TD></TR><TR><TD class=indicatorInfo align=middle colSpan=7>(Periodicity: Week, Applied Time Period: from 41/2008 to 46/2008)</TD></TR><TR><TD class=content vAlign=top>1.</TD><TD class=content vAlign=top width=161>Belarus</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>2.</TD><TD class=content vAlign=top width=161>Belarus</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>45</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>3.</TD><TD class=content vAlign=top width=161>Belgium</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>4.</TD><TD class=content vAlign=top width=161>Belgium</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>5.</TD><TD class=content vAlign=top width=161>Belgium</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>6.</TD><TD class=content vAlign=top width=161>Belgium</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>7.</TD><TD class=content vAlign=top width=161>Brazil</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>8.</TD><TD class=content vAlign=top width=161>Brazil</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>9.</TD><TD class=content vAlign=top width=161>Brazil</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>10.</TD><TD class=content vAlign=top width=161>Brazil</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>11.</TD><TD class=content vAlign=top width=161>Brazil</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>45</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>12.</TD><TD class=content vAlign=top width=161>Brazil</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>46</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>13.</TD><TD class=content vAlign=top width=161>Bulgaria</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>14.</TD><TD class=content vAlign=top width=161>Bulgaria</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>15.</TD><TD class=content vAlign=top width=161>Bulgaria</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>16.</TD><TD class=content vAlign=top width=161>Bulgaria</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>17.</TD><TD class=content vAlign=top width=161>Bulgaria</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>45</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>18.</TD><TD class=content vAlign=top width=161>Cameroon</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>19.</TD><TD class=content vAlign=top width=161>Cameroon</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>1</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>20.</TD><TD class=content vAlign=top width=161>Cameroon</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>21.</TD><TD class=content vAlign=top width=161>Cameroon</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>22.</TD><TD class=content vAlign=top width=161>Cameroon</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>45</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>2</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>23.</TD><TD class=content vAlign=top width=161>Cameroon</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>46</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>24.</TD><TD class=content vAlign=top width=161>Canada</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>25.</TD><TD class=content vAlign=top width=161>Canada</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>26.</TD><TD class=content vAlign=top width=161>Canada</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>27.</TD><TD class=content vAlign=top width=161>Canada</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>28.</TD><TD class=content vAlign=top width=161>Canada</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>45</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>29.</TD><TD class=content vAlign=top width=161>Chile</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>30.</TD><TD class=content vAlign=top width=161>Chile</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>31.</TD><TD class=content vAlign=top width=161>Chile</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>32.</TD><TD class=content vAlign=top width=161>China</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>25</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>33.</TD><TD class=content vAlign=top width=161>China</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>16</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>34.</TD><TD class=content vAlign=top width=161>China</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>7</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>35.</TD><TD class=content vAlign=top width=161>China</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>7</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>36.</TD><TD class=content vAlign=top width=161>China</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>45</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>5</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>37.</TD><TD class=content vAlign=top width=161>China</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>46</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>6</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>38.</TD><TD class=content vAlign=top width=161>Colombia</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>39.</TD><TD class=content vAlign=top width=161>Colombia</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>40.</TD><TD class=content vAlign=top width=161>Denmark</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>41.</TD><TD class=content vAlign=top width=161>Denmark</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>42.</TD><TD class=content vAlign=top width=161>Denmark</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>43.</TD><TD class=content vAlign=top width=161>Denmark</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>44.</TD><TD class=content vAlign=top width=161>Denmark</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>45</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>45.</TD><TD class=content vAlign=top width=161>Egypt</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>46.</TD><TD class=content vAlign=top width=161>Egypt</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>47.</TD><TD class=content vAlign=top width=161>Egypt</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>45</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>48.</TD><TD class=content vAlign=top width=161>Finland</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>49.</TD><TD class=content vAlign=top width=161>Finland</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>50.</TD><TD class=content vAlign=top width=161>Finland</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>51.</TD><TD class=content vAlign=top width=161>Finland</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>52.</TD><TD class=content vAlign=top width=161>Finland</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>45</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>53.</TD><TD class=content vAlign=top width=161>France</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>54.</TD><TD class=content vAlign=top width=161>France</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>55.</TD><TD class=content vAlign=top width=161>France</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>56.</TD><TD class=content vAlign=top width=161>France</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>57.</TD><TD class=content vAlign=top width=161>France</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>45</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>58.</TD><TD class=content vAlign=top width=161>Germany</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>59.</TD><TD class=content vAlign=top width=161>Germany</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>60.</TD><TD class=content vAlign=top width=161>Greece</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>61.</TD><TD class=content vAlign=top width=161>Greece</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>62.</TD><TD class=content vAlign=top width=161>Greece</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>63.</TD><TD class=content vAlign=top width=161>Greece</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>64.</TD><TD class=content vAlign=top width=161>Greece</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>45</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>65.</TD><TD class=content vAlign=top width=161>Honduras</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>66.</TD><TD class=content vAlign=top width=161>Iran (Islamic Republic of)</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>67.</TD><TD class=content vAlign=top width=161>Iran (Islamic Republic of)</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>68.</TD><TD class=content vAlign=top width=161>Iran (Islamic Republic of)</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>69.</TD><TD class=content vAlign=top width=161>Iran (Islamic Republic of)</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>70.</TD><TD class=content vAlign=top width=161>Iran (Islamic Republic of)</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>45</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>1</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>71.</TD><TD class=content vAlign=top width=161>Iran (Islamic Republic of)</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>46</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>72.</TD><TD class=content vAlign=top width=161>Japan</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>73.</TD><TD class=content vAlign=top width=161>Japan</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>74.</TD><TD class=content vAlign=top width=161>Japan</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>4</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>75.</TD><TD class=content vAlign=top width=161>Japan</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>76.</TD><TD class=content vAlign=top width=161>Japan</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>45</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>77.</TD><TD class=content vAlign=top width=161>Kenya</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>78.</TD><TD class=content vAlign=top width=161>Kenya</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>79.</TD><TD class=content vAlign=top width=161>Kenya</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>80.</TD><TD class=content vAlign=top width=161>Kenya</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>81.</TD><TD class=content vAlign=top width=161>Kenya</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>45</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>82.</TD><TD class=content vAlign=top width=161>Latvia</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>83.</TD><TD class=content vAlign=top width=161>Latvia</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>84.</TD><TD class=content vAlign=top width=161>Latvia</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>85.</TD><TD class=content vAlign=top width=161>Latvia</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>45</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>86.</TD><TD class=content vAlign=top width=161>Mexico</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>87.</TD><TD class=content vAlign=top width=161>Mexico</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>88.</TD><TD class=content vAlign=top width=161>Mexico</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>89.</TD><TD class=content vAlign=top width=161>Mongolia</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>90.</TD><TD class=content vAlign=top width=161>Mongolia</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>91.</TD><TD class=content vAlign=top width=161>Mongolia</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>92.</TD><TD class=content vAlign=top width=161>Mongolia</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>93.</TD><TD class=content vAlign=top width=161>Netherlands</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>94.</TD><TD class=content vAlign=top width=161>Norway</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>95.</TD><TD class=content vAlign=top width=161>Norway</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>96.</TD><TD class=content vAlign=top width=161>Norway</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>97.</TD><TD class=content vAlign=top width=161>Norway</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>1</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>98.</TD><TD class=content vAlign=top width=161>Norway</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>45</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>99.</TD><TD class=content vAlign=top width=161>Oman</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>100.</TD><TD class=content vAlign=top width=161>Oman</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>101.</TD><TD class=content vAlign=top width=161>Oman</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>102.</TD><TD class=content vAlign=top width=161>Oman</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>103.</TD><TD class=content vAlign=top width=161>Oman</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>45</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>104.</TD><TD class=content vAlign=top width=161>Poland</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>105.</TD><TD class=content vAlign=top width=161>Poland</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>106.</TD><TD class=content vAlign=top width=161>Poland</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>107.</TD><TD class=content vAlign=top width=161>Poland</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>108.</TD><TD class=content vAlign=top width=161>Poland</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>45</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>109.</TD><TD class=content vAlign=top width=161>Portugal</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>110.</TD><TD class=content vAlign=top width=161>Portugal</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>111.</TD><TD class=content vAlign=top width=161>Portugal</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>112.</TD><TD class=content vAlign=top width=161>Portugal</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>113.</TD><TD class=content vAlign=top width=161>Portugal</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>45</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>114.</TD><TD class=content vAlign=top width=161>Romania</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>115.</TD><TD class=content vAlign=top width=161>Romania</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>116.</TD><TD class=content vAlign=top width=161>Romania</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>117.</TD><TD class=content vAlign=top width=161>Romania</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>118.</TD><TD class=content vAlign=top width=161>Romania</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>45</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>119.</TD><TD class=content vAlign=top width=161>Russian Federation</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>2</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>120.</TD><TD class=content vAlign=top width=161>Russian Federation</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>4</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>121.</TD><TD class=content vAlign=top width=161>Russian Federation</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>5</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>122.</TD><TD class=content vAlign=top width=161>Russian Federation</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>4</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>123.</TD><TD class=content vAlign=top width=161>Russian Federation</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>45</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>124.</TD><TD class=content vAlign=top width=161>Slovenia</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>125.</TD><TD class=content vAlign=top width=161>Slovenia</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>126.</TD><TD class=content vAlign=top width=161>Slovenia</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>127.</TD><TD class=content vAlign=top width=161>Slovenia</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>128.</TD><TD class=content vAlign=top width=161>Slovenia</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>45</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>129.</TD><TD class=content vAlign=top width=161>South Africa</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>130.</TD><TD class=content vAlign=top width=161>Spain</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>131.</TD><TD class=content vAlign=top width=161>Spain</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>132.</TD><TD class=content vAlign=top width=161>Spain</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>133.</TD><TD class=content vAlign=top width=161>Spain</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>134.</TD><TD class=content vAlign=top width=161>Sri Lanka</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>135.</TD><TD class=content vAlign=top width=161>Sri Lanka</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>136.</TD><TD class=content vAlign=top width=161>Sri Lanka</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>137.</TD><TD class=content vAlign=top width=161>Sri Lanka</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>138.</TD><TD class=content vAlign=top width=161>Sweden</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>139.</TD><TD class=content vAlign=top width=161>Sweden</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>140.</TD><TD class=content vAlign=top width=161>Switzerland</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>141.</TD><TD class=content vAlign=top width=161>Switzerland</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>142.</TD><TD class=content vAlign=top width=161>Switzerland</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>143.</TD><TD class=content vAlign=top width=161>Switzerland</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>144.</TD><TD class=content vAlign=top width=161>Switzerland</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>45</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>145.</TD><TD class=content vAlign=top width=161>Tunisia</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>146.</TD><TD class=content vAlign=top width=161>Tunisia</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>45</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>1</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>147.</TD><TD class=content vAlign=top width=161>Tunisia</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>46</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>1</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>148.</TD><TD class=content vAlign=top width=161>Ukraine</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>149.</TD><TD class=content vAlign=top width=161>United Kingdom of Great Britain and Northern Ireland</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>2</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>150.</TD><TD class=content vAlign=top width=161>United Kingdom of Great Britain and Northern Ireland</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>151.</TD><TD class=content vAlign=top width=161>United Kingdom of Great Britain and Northern Ireland</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>3</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>152.</TD><TD class=content vAlign=top width=161>United Kingdom of Great Britain and Northern Ireland</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>1</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>153.</TD><TD class=content vAlign=top width=161>United Kingdom of Great Britain and Northern Ireland</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>45</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>4</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>154.</TD><TD class=content vAlign=top width=161>United States of America</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>4</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>155.</TD><TD class=content vAlign=top width=161>United States of America</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>42</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>12</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>156.</TD><TD class=content vAlign=top width=161>United States of America</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>43</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>14</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>157.</TD><TD class=content vAlign=top width=161>United States of America</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>44</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>2</TD><TD class=content vAlign=top align=middle>view</TD></TR><TR><TD class=content vAlign=top>158.</TD><TD class=content vAlign=top width=161>Uruguay</TD><TD class=content vAlign=top>A (H1)</TD><TD class=content vAlign=top align=middle>41</TD><TD class=content vAlign=top align=middle>2008</TD><TD class=content vAlign=top align=middle>0</TD><TD class=content vAlign=top align=middle>view</TD></TR></TBODY></TABLE></TD><TD class=ContentTop width=14></TD></TR></TBODY></TABLE>

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