Originally Posted by niman
The above translation confirms that the patient had been in contact with an infected person abroad, but had been asymptomatic in Denmark for five before becoming ill. A sample was collected and sequenced in Denmark and England (Weybridge or Mill Hill) and both labs identified a resistance marker (almost certainly H274Y).
The long incubation time of 5 days leaves open the source of the infection. Since the patient was asymptomatic upon arrival, it is unlikley that there are samples collected prior to the start of prophylactic treatment and even if a sample existed, it is unlikely that virus could be isolated.
In fact the 5 day delay in disease onset leave open the strong possibility that the patient was NOT infected by the known foreign contact, and was in fact infected while traveling to Denmark or after arriving in Denmark.
The resistance was identified because the patient developed symptoms (five DAYS after arriving, suggesting the infecting dose was low if it originated outside of Denmark) while being treated, but there is NO evidence even remotely suggesting that the patient was infected by wild type H1N1, unless virus was isolated from the foreign contact, or that the two isolates matched (other than the acquired resistance markers). The article makes no mention of an isolate or sequence from the known contact, and without such a match, there is nothing to suggest that the resistance developed while under prophylactic treatment.
I´m danish, and I have now read several of the Tamiflu resistant patient reports in danish, and I belive fully that this is the correct info due to what has been reported on Statens Serum Institut website and elsewere.
It was only the report from "Ekstrabladet" which was written in a way that could be misunderstod in regards to were "A" had been infected, but it turn out that it was aimed to the location were "B" was infected; abroad.
So, here is the correct info:
The tamiflu resistent person "A" (a woman, according to newsreport) had NOT been abroad.
"A" had been in contact with a person, we name him/her "B"
"B" had recently been abroad and had gotten infected with H1N1
Therefore "A " was given Tamiflu as a precausionn treatment
After "A" had been taking Tamiflu for 5 days she devloped flu symptoms
A test showed that "A" was infected with H1N1
Additional tests at Statens Serum Institut showed that the virus in question, H1N1, had mutated. It (the H1N1) is resistent to tamiflu but is still sensetive to Relenza.
If I find additional info I´ll post it in this thread.
By the way the machin translation is VERY bad, belive me