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Norway - H1N1 "Mutation" Announced by Health Department

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  • #16
    Re: Change in virus in Norway- no reason for panic

    > The mutation is discussed with the World Health Organization
    > (WHO) Friday, and WHO reports that the mutation is also
    > found in other countries.
    > Japan, Brazil, USA and China are in addition to Norway the other
    > countries which have signed this mutation.


    not Ukraine ?

    we get hints ... is this a puzzle ?
    I'm interested in expert panflu damage estimates
    my current links: http://bit.ly/hFI7H ILI-charts: http://bit.ly/CcRgT

    Comment


    • #17
      Re: Change in virus in Norway- no reason for panic

      More aggressive swine influenza virus detected in Norway

      - TA Vaccine: of Public Health (FHI) and the Health Directorate's fixed by the council that all should accept the offer of the vaccine. Although it has been found mutations in the virus, there is nothing to suggest that the virus is resistant to Pandrmix or Tamiflu. Photo: Scanpix
      By Ingunn Andersen 20.11.2009 kl. 15:27 Kilde: VG NETT

      (AP) Norwegian health authorities to investigate a new type of H1N1 virus that is found in two dead patients. The mutation probably affects the virus's ability to attach itself deeper into the airways.

      As part of the surveillance of the virus has of Public Health (FHI) analyzed the virus from many patients.

      Viruses have great similarities with each other, but some mutations have been found in some of them. One of the mutations has captured much interest, and reported on to the World Health Organization (WHO).

      Read also: Lover vaccine to eggallergikere

      The mutation should not affect the efficacy of the vaccine or Tamiflu.



      Three patients

      The mutation is found in the virus at two of the patients who died from the new flu in July and August, health authorities said during a news conference Friday.

      One of the patients will have been infected abroad, while the other probably was infected in Norway.

      The mutation is also found in a patient with severe influnesasykdom.

      - Based on what we know so far, it appears that the mutated virus is not circulating in the population, but there can be talk of spontaneous changes that have occurred in three patients, "said Geir Stene-Larsen, director of Public Health (FHI).

      In Norway, a total of 23 persons died of swine flu.

      The mutation is known in several other countries, but Stene-Larsen stressed that it is important to examine whether there still is something about the Norwegian death that separates us from other countries.

      - We also have international obligations in relation to share new knowledge, "he says.



      - The summit reached

      Health authorities believe that just under 700,000 people have been svineinfluensasmitten in Norway. After a record-breaking 45 weeks, the infection is now on the way down in South and Central Norway. They estimate that the infection has peaked in this country.

      - We can never be sure, but on the basis of the experience we have from previous epidemics, see it now so that the curves are coming down again. The figures are substantially lower now than last week, "said Public Health Director to NTB.

      70 patients examined

      According to FHI we are talking about a so-called point mutation, which affects the cells the virus can deal with.

      The number of dead in Norway is high compared to the rest of Europe, but health authorities do not believe this is due to mutations that are specific to the virus.

      - We have also reason to believe that this is due to the pandemic hit us heavily before we got started with vaccination, "said Health Director Bj?rn Inge Larsen in the Health Directorate.



      (Reuters 20.11.2009http://www.vg.no/helse/svineinfluens...p?artid=592500
      CSI:WORLD http://swineflumagazine.blogspot.com/

      treyfish2004@yahoo.com

      Comment


      • #18
        Re: Norway - Change or Variant in Virus? - "no reason for panic"

        This is my summary from norwegian radio and TV.
        The change is serious- but not new. ? will be investigated further. It has been found in two patients who died and in one patient with serious sickness from the flu.

        This mutation is likely to help the virus to go deeper in the lungs, and therefore cause more serious diseases. Also probably more likely to get pneumonia with the mutated virus.

        The mutation doesn?t seem to circulate, but this shows the virus is unstable.
        The public health expect that most people will get the mild type. The public health will investigate if this mutation can explain why some people get very serious sickness.
        Tamiflu still works, and also most likely the vaccine.

        The only thing that has changed is that we now know about this, we already knew this virus is very serious for some.

        Comment


        • #19
          Re: Norway - Change or Variant in Virus? - "no reason for panic"

          so, what's the estimate CFR in Norway as compared with
          similar countries ? (Sweden ?)
          I'm interested in expert panflu damage estimates
          my current links: http://bit.ly/hFI7H ILI-charts: http://bit.ly/CcRgT

          Comment


          • #20
            Re: Norway - Virus has changed "slightly"

            20. November 2009 KL. 16:34
            H1N1 gives new shock in Norway
            The virus started to mutate. It makes it harder to bek?mpe.Lige as H1N1 influenzaneen was abating somewhat in Norway, has health experts in the country got itself a shock:

            The virus has begun to mutate, so its genetic composition will change.

            Thus it may be more dangerous and harder to combat. It is serious, but there is no reason to panic, said the Norwegian health authorities, which has just held a press conference on the new discovery.

            Norway extra hard hit
            So far, 23 people died after receiving Influenza A (H1N1), also known as swine flu.

            Up to one million Norwegians are believed to have had influenzanen already. Thus, the country relative to its size hit harder than most other countries.

            "We found the mutant virus in two patients who died in Norway, which means that this virus may have circulated in Norway since the pandemic began. Therefore we expect no major change in the situation in the future, "says director since Norwegian helsedirektoratet, Bj?rn-Inge Larsen told the newspaper Aftenposten.

            According to Aftenposten, the mutated virus allegedly also been registered in other countries.

            The new mutated virus thrives further down the airways than the original. This implies more severe disease compared to the original H1N1 influenza, which only affects the neck and upper parts of airways.



            The virus has changed
            Laboratory samples from 70 patients have been studied and found viruses with mutations in the three of them. Two of the three people who had the mutated virus in the body, is now dead.

            The samples have been studied both in Norway and in London with experts from the World Health Organization. Here it has been confirmed that the virus has changed.

            The authorities point out that influenza attack with the mutant virus can be prevented with the known Influenza A vaccine and fought with the drug Tamiflu.

            Moreover, assuming that it is less contagious than the original A (H1N1).
            http://politiken.dk/udland/article840879.ece
            CSI:WORLD http://swineflumagazine.blogspot.com/

            treyfish2004@yahoo.com

            Comment


            • #21
              Re: Norway - Virus has changed "slightly"

              Norwegian mutated H1N1 virus does not lead to Finland
              20.11.2009, 15.55 (updated 17.29)

              Norway revealed swine influenza virus variant does not cause changes in the Finnish vaccination program or a disease. Research Professor Ilkka Julkunen Health and Welfare Department to confirm that the virus is converted, but very minimally.

              - Biotransformation of less than one percent of the original virus.

              Finnish vaccination plans in Norway Found variant at least not at this stage have no effect. The current vaccine is produced in the first autumn, followed by a virus update.

              Julkunen points out that in Finland there are two sikainfluenssaan power to open the medicine. Tamiflu is in stock and 1.9 million treatment course for viral influenza treatment Relenza 800 000 Curia.

              According to newspaper Aftenposten, the Norwegian scientists have found a variant of swine influenza virus. In laboratory studies, muuntunutta virus were found in five patients, of whom two have died, and three in intensive care.

              Although the virus has mutated, no reason to panic, the Norwegian Public Health Institute, no.

              According to the researchers mutated virus will strike the lower respiratory tract than previously known strain of the virus, but less is transmitted.http://plaza.fi/ulkomaat/norjan-muun...oimia-suomessa
              CSI:WORLD http://swineflumagazine.blogspot.com/

              treyfish2004@yahoo.com

              Comment


              • #22
                Re: Norway - Change or Variant in Virus? - "no reason for panic"

                Originally posted by Anty View Post
                This is my summary from norwegian radio and TV.
                The change is serious- but not new. – will be investigated further. It has been found in two patients who died and in one patient with serious sickness from the flu.

                This mutation is likely to help the virus to go deeper in the lungs, and therefore cause more serious diseases. Also probably more likely to get pneumonia with the mutated virus.

                The mutation doesn’t seem to circulate, but this shows the virus is unstable.
                The public health expect that most people will get the mild type. The public health will investigate if this mutation can explain why some people get very serious sickness.
                Tamiflu still works, and also most likely the vaccine.

                The only thing that has changed is that we now know about this, we already knew this virus is very serious for some.

                We have known in the US and many other places for months that there can be a deep lung characterization of the disease progression. Sometimes this leads to death and organ failure. This was evidenced as early as the original infections in Mexico.

                Critically Ill Patients With 2009 Influenza A(H1N1) in Mexico




                So unless there is a significantly higher cfr associated with the infections in Norway then this would appear to be what we have been seeing for months.

                Comment


                • #23
                  Re: Change in virus in Norway- no reason for panic

                  Originally posted by Andy2000 View Post
                  These isolates in Genbank have D225G (includes Brazil/Japan/China/USA)

                  gb|GU189649.1| Influenza A virus (A/Zhejiang/DTID-ZJU03/2009(... 34.2 3.0
                  gb|GU112090.1| Influenza A virus (A/Zhejiang/DTID-ZJU02/2009(... 34.2 3.0
                  gb|GU108486.1| Influenza A virus (A/Zhejiang-Yiwu/11/2009(H1N... 34.2 3.0
                  gb|CY047074.1| Influenza A virus (A/Catalonia/NS1706/2009(H1N... 34.2 3.0
                  gb|GU014750.1| Influenza A virus (A/Hiroshima/201/2009(H1N1))... 34.2 3.0
                  gb|GQ915018.1| Influenza A virus (A/Sao Paulo/53225/2009(H1N1... 34.2 3.0
                  gb|GQ915017.1| Influenza A virus (A/Sao Paulo/53206/2009(H1N1... 34.2 3.0
                  gb|GQ457487.1| Influenza A virus (A/Texas/05/2009(H1N1)) segm... 34.2 3.0
                  gb|GQ379822.1| Influenza A virus (A/Mexico/InDRE4114/2009(H1N... 34.2 3.0
                  gb|GQ374893.1| Influenza A virus (A/reassortant/IDCDC-RG18(Te... 34.2 3.0
                  gb|GQ280121.1| Influenza A virus (A/reassortant/NIBRG-121(Cal... 34.2 3.0
                  gb|GQ232076.1| Influenza A virus (A/Texas/11/2009(H1N1)) segm... 34.2 3.0
                  gb|GQ200237.1| Influenza A virus (A/Georgia/01/2009(H1N1)) se... 34.2 3.0
                  gb|GQ162194.1| Influenza A virus (A/Mexico/3955/2009(H1N1)) s... 34.2 3.0
                  gb|GQ160568.1| Influenza A virus (A/New York/04/2009(H1N1)) s... 34.2 3.0
                  gb|GQ132145.1| Influenza A virus (A/Mexico/InDRE4114/2009(H1N... 34.2 3.0


                  ------

                  Florida1,

                  Norway released three isolates into Genbank on September 22nd from May/June.

                  Are these all serious cases ? What is the known CFR for cases with this mutation. Important questions we need to find the answers to.

                  Comment


                  • #24
                    Re: Norway - Virus has changed "slightly"

                    Thank you Toaster2. I agree.

                    Comment


                    • #25
                      Re: Norway - Virus has changed "slightly"

                      It looks to me that in the GISAID data base the Norwegian patients survived. No deaths reported. Someone please correct me if I am wrong. I have only had access to this data base for 24 hours.

                      Comment


                      • #26
                        Re: Norway - Virus has changed "slightly"

                        Originally posted by Florida1 View Post
                        Thank you Toaster2. I agree.
                        - Norway 2/70 deaths confirmed with mutation, 3 others have it with severe disease (so 40% of the people with mutation died)
                        - Ukraine 10 sequences, 4 who had the mutation died, the others didn't and did not die (100% of people with mutation died)


                        Other countries with D225G :
                        China
                        Japan
                        Australia
                        USA
                        Brazil
                        MExico

                        Can we sticky this and let people who find out stuff add this to the list so we can get an overview ?

                        Comment


                        • #27
                          Re: Norway - Virus has changed "slightly"

                          Sure. A separate thread for 225?

                          Comment


                          • #28
                            Re: Norway - Virus has changed "slightly"

                            is D225G the reason for many/most deaths in Argentina,Mexico,USA...
                            but they failed to find it or kept it secret

                            or does D225G for some reason happen more likely now in Europe
                            than it did before in America,Asia,Australia
                            I'm interested in expert panflu damage estimates
                            my current links: http://bit.ly/hFI7H ILI-charts: http://bit.ly/CcRgT

                            Comment


                            • #29
                              Re: Norway - Virus has changed "slightly"

                              Svinfluensan mutation
                              The virus can reach further into the lungs
                              Swine influenza virus has mutated.
                              2009-11-20
                              The new variant, which appeared in both Sweden and Norway, can reach deeper into the lungs and be more serious for the patient.

                              But Norwegian and Swedish health authorities say there is no reason to panic.

                              Norway has been more affected by the new influenza A/H1N1 than Sweden and so far 23 people have died in the impact of the virus and at least 700 000 have fallen ill.

                              The Norwegian institute of health (FHI) is monitoring the situation closely and have done extensive testing of the virus from both diseased and deceased patients, writes VG.

                              "After further down into the lungs"
                              Today at a press conference revealed FHI that Norway seems to have suffered a more aggressive virus than many other countries.

                              They found evidence that the swine flu virus has mutated into at least three cases, and that it takes longer into the lungs than in normal swine influenza. The results have been presented to the World Health Organization.

                              - The mutant virus causes a mild illness in most, but can be serious for a few. This variant can reach further into the lungs than the original version, "said Director Geir Stene-Larsen on the National Public Health Institute in a press conference on Friday, according to VG.

                              Even in Sweden
                              The same variant of swine influenza virus detected in Norway has also been found in Sweden, in both seriously ill, mildly ill and in people who are not sick at all, writes TT.
                              But neither the Swedish Institute of Infectious Disease Control (SMI) or the WHO has so far found no evidence of changes in the circulating strains that make the new flu more aggressive.

                              The signs are that the vaccine and Tamiflu works the same way against the new, mutated virus. And the Norwegian Health Organization says there are no indications that more will be affected by the mutated H1N1 virus.

                              Since, as we have seen so far, only occurred in patients who remained hospitalized for so experts expect that it is less contagious.

                              - For those of us who are now seeing the disease around us, and for those who become sick in the future, so might not mean this so much. We expect that most will have a mild form of the disease, says health director Bj?rn-Inge Larsen to NRK. http://www.aftonbladet.se/nyheter/article6160420.ab
                              CSI:WORLD http://swineflumagazine.blogspot.com/

                              treyfish2004@yahoo.com

                              Comment


                              • #30
                                Re: Norway - Virus has changed "slightly"

                                Discovered in Norway a very serious H1N1 mutation
                                The Public Health Institute has found in two dead, but believes that it is expanding
                                E. OF B. - Madrid - 20/11/2009

                                Public Health Institute in Norway today reported it has identified a mutation of H1N1 is associated with a more severe form of the disease. The virus has been isolated from samples taken from three patients, two who have died and one that has been very serious. This variant, however, has not been located then in the following deceased (the country had informed the European Center for Disease Control, ECDC, on 18 November that there were 21 deaths associated with the new flu), which is a good news.

                                Researchers believe that as no virus found circulating with the same characteristics it is likely that the mutation that causes the disease spreading deeper into the respiratory system occurred in the subjects. Of course that would not explain the similarity, with what the other options being considered is to have a mutation and a relationship between patients, although the Norwegian Institute for Health does not provide that information. http://www.elpais.com/articulo/socie...pepusoc_21/Tes
                                CSI:WORLD http://swineflumagazine.blogspot.com/

                                treyfish2004@yahoo.com

                                Comment

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