Map of Heilongjiang Province in China in relation to the provinces and municipalities that have reported H7N9 cases

[Laidback Al]

Welcome to FluTrackers, Stevevit.

The map belows shows the location of Heilongjiang Province in China in relation to the provinces and municipalities that have reported H7N9 cases.

So far no H7N9 cases have been reported from Heilongjiang Province. The news thread is simply reporting about some individuals that may have been admitted to hospitals with respiratory infections. FluTrackers members post these kinds of media reports every day from around the world. Almost all of them are a result of people suffering from everyday illnesses. This first report should not be of concern to you, but you should continue to follow the Heilongjiang thread to see if there are future developments.




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[NS1]

Re: China - A report of at least 30 people admitted to hospitals in Heilongjiang province on May 1st due to respiratory diseases - weather changes blamed

Historical pH1N1
from
Heilongjiang Province

pH1N1 sequences from that region are sparse (12) and not current (2011 Latest) but do match contemporaneous circulation in Beijing, Guangdong, Jiangsu and Hunan indicating that the area gets similar transmission patterns. Notable HA polymorphisms include Vaccine Escape marker 158E, Receptor Binding Site 194I / 225G / 226R and 245I (Novel to pH1N1).

Hemagglutinin Polymorphisms from this region on pH1N1 match Emergent H7N9 at -2I, 5K, 116K & 447K and share homology with ΣH7N7 at 17 of 45 distinct changes across 12 sequences. Incidentally, HA 116K disappeared from Pandemic H1N1 sequences after 5 showings up to March 2010 (3 Asia / 1 Africa / 1 US) and re-emerged in a pH1N1 deposit made by the US CDC a few days ago from a human sample taken in late March 2013 in the United States, a polymorphism not present for 3 years in humans.

The HA and NA each shows trace mixture, potentially indicating co-infection. The NA segment across these 12 sequences is divergent. pH1N1 and Emergent H7N9 share Neuraminidase homology at 74I.

Although the genetic tracking information is dated for this region, evidence appears that human disease has been influenced in the past by avian strains in a pattern suggestive of viral reservoir interchange at the avian stage prior to human infection. The database records wild avian H1N1 sharing Polymerase with wild avian H7N9 in 2011 common time and location demonstrating compatibility of modern diverse serotype backgrounds. We've all witnessed the serotype variation of the ill-fitting, BLAST-proposed emergent H7N9 ancestry trees. The new genotype is likely to have numerous viable options. Given migration systems and this genetic evidence, Heilongjiang Province is certainly a candidate to receive the next step in emergent H7N9 genetic maturation.

We'd like to ask if Heilongjiang is also having equine / canine viral outbreaks of pathogens not generally associated with Influenza.

HA Polymorphisms

. . . . ChinaHeilongjiangLongshaSWL1181_C3_3M_2011_04_08 (
. . . . . . . . GISAID HA EPI330849
. . . . . . . . GISAID Isolate EPI_ISL_94652
. . . . . . . . 14 Polymorphisms (6 Amino and 8 Silent)
. . . . . . . . #6M [H9N2],
. . . . . . . . syn34N (AAt),
. . . . . . . . syn108L (cTG) [H5N1],
. . . . . . . . . . . . . . . . . . [avH1N1farm],
. . . . . . . . syn122K (AAa),
. . . . . . . . 146G,
. . . . . . . . 188T,
. . . . . . . . 200T,
. . . . . . . . syn338G (GGc),
. . . . . . . . 377K,
. . . . . . . . syn405K (AAg) [Emergent H7N9],
. . . . . . . . . . . . . . . . . . .[H5N1],
. . . . . . . . 454N,
. . . . . . . . syn465N (AAt),
. . . . . . . . syn474C (TGt),
. . . . . . . . syn538F (TTt))

. . . . ChinaHeilongjiangXiangfangSWL1528_E2_2M_2011_03_04 (
. . . . . . . . GISAID HA EPI330673
. . . . . . . . GISAID Isolate EPI_ISL_94630
. . . . . . . . 15 Polymorphisms (9 Amino and 6 Silent)
. . . . . . . . #6M [H9N2],
. . . . . . . . syn34N (AAt),
. . . . . . . . syn122K (AAa),
. . . . . . . . 146G,
. . . . . . . . 158E,
. . . . . . . . syn173G (GGa),
. . . . . . . . 188T,
. . . . . . . . 194I,
. . . . . . . . 200T,
. . . . . . . . 225G,
. . . . . . . . syn338G (GGc),
. . . . . . . . 377K,
. . . . . . . . 454N,
. . . . . . . . syn465N (AAt),
. . . . . . . . syn538F (TTt))

. . . . ChinaHeilongjiangXiangyangSWL196_C2_3M_2011_03_03 (
. . . . . . . . GISAID HA EPI330300
. . . . . . . . GISAID Isolate EPI_ISL_94579
. . . . . . . . 5 Polymorphisms (5 Amino and 0 Silent)
. . . . . . . . 131P,
. . . . . . . . 210N [H5N1],
. . . . . . . . . . . . .[H9N2],
. . . . . . . . . . . . .[avH1N1farm],
. . . . . . . . 211R [H7N7],
. . . . . . . . . . . . .[H9N2],
. . . . . . . . . . . . .[avH1N1farm],
. . . . . . . . . . . . .[H13N2],
. . . . . . . . 245I [sH3N2],
. . . . . . . . . . . . [H9N2],
. . . . . . . . . . . . [H7N9 LAd],
. . . . . . . . 447K [Emergent H7N9],
. . . . . . . . . . . . [sH3N2])

. . . . ChinaHeilongjiangXiangfang196_C2C1_2011_03_03 (
. . . . . . . . GISAID HA EPI320020
. . . . . . . . GISAID Isolate EPI_ISL_90926
. . . . . . . . 5 Polymorphisms (5 Amino and 0 Silent)
. . . . . . . . 131P,
. . . . . . . . 210N [H5N1],
. . . . . . . . . . . . .[H9N2],
. . . . . . . . . . . . .[avH1N1farm],
. . . . . . . . 211R [H7N7],
. . . . . . . . . . . . .[H9N2],
. . . . . . . . . . . . .[avH1N1farm],
. . . . . . . . . . . . .[H13N2],
. . . . . . . . 245I [sH3N2],
. . . . . . . . . . . . [H9N2],
. . . . . . . . . . . . [H7N9 LAd],
. . . . . . . . 447K [Emergent H7N9],
. . . . . . . . . . . . [sH3N2])

. . . . ChinaHeilongjiangXiangfang191_E1E3_2011_01_08 (
. . . . . . . . GISAID HA EPI325576
. . . . . . . . GISAID Isolate EPI_ISL_93610
. . . . . . . . 14 Polymorphisms (7 Amino and 7 Silent)
. . . . . . . . #6M [H9N2],
. . . . . . . . syn21T (ACc) [H7N7],
. . . . . . . . syn34N (AAt),
. . . . . . . . syn47L (tTA),
. . . . . . . . syn122K (AAa),
. . . . . . . . 146G,
. . . . . . . . 188T,
. . . . . . . . 200T,
. . . . . . . . 226R,
. . . . . . . . syn338G (GGc),
. . . . . . . . 377K,
. . . . . . . . 454N,
. . . . . . . . syn465N (AAt),
. . . . . . . . syn538F (TTt))

. . . . ChinaHeilongjiangLongshaSWL19_C4_27F_2010_01_13 (
. . . . . . . . GISAID HA EPI258044
. . . . . . . . GISAID Isolate EPI_ISL_75039
. . . . . . . . 4 Polymorphisms (1 Amino and 3 Silent)
. . . . . . . . 116K [Emergent H7N9],
. . . . . . . . syn175E (GAg) [avH1N1],
. . . . . . . . syn177L (CTt) [H9N2],
. . . . . . . . . . . . . . . . . . [avH1N1farm],
. . . . . . . . . . . . . . . . . . [H6N1],
. . . . . . . . . . . . . . . . . . [H10N7],
. . . . . . . . syn541C (TGt) [Emergent H7N9])

. . . . ChinaHeilongjiangJianhuaSWL18_C4_11M_2010_01_09 (
. . . . . . . . GISAID HA EPI258040
. . . . . . . . GISAID Isolate EPI_ISL_75038
. . . . . . . . 4 Polymorphisms (1 Amino and 3 Silent)
. . . . . . . . 131P,
. . . . . . . . syn177L (CTt) [H9N2],
. . . . . . . . . . . . . . . . . . [avH1N1farm],
. . . . . . . . . . . . . . . . . . [H6N1],
. . . . . . . . . . . . . . . . . . [H10N7],
. . . . . . . . syn184H (CAc),
. . . . . . . . syn359E (GAa) [H5N1, avH1N1, H13N2])

. . . . ChinaHeilongjiangXiangfangSWL1970_C2_20F_2009_12_3 0 (
. . . . . . . . GISAID HA EPI257580
. . . . . . . . GISAID Isolate EPI_ISL_74923
. . . . . . . . 7 Polymorphisms (2 Amino and 5 Silent)
. . . . . . . . syn255R (AGg) [avH3N2],
. . . . . . . . 265E [avH1N1],
. . . . . . . . syn268I (ATc),
. . . . . . . . 377K,
. . . . . . . . syn413K (AAg),
. . . . . . . . syn429L (TTa),
. . . . . . . . syn432L (TTa))

. . . . ChinaHeilongjiangLongshaSWL1424_C1_22F_2009_12_19 (
. . . . . . . . GISAID HA EPI257584
. . . . . . . . GISAID Isolate EPI_ISL_74924
. . . . . . . . 2 Polymorphisms (0 Amino and 2 Silent)
. . . . . . . . syn175E (GAg) [avH1N1],
. . . . . . . . syn541C (TGt) [Emergent H7N9])

. . . . ChinaHeilongjiangJianhuaSWL1574_C1_4F_2009_12_14 (
. . . . . . . . GISAID HA EPI257456
. . . . . . . . GISAID Isolate EPI_ISL_74892
. . . . . . . . 5 Polymorphisms (2 Amino and 3 Silent)
. . . . . . . . #2I [Emergent H7N9],
. . . . . . . . . . . [H5N1, H13],
. . . . . . . . syn99I (ATa) [H7N7],
. . . . . . . . . . . . . . . . . [avH1N1farm],
. . . . . . . . syn228G (GGa),
. . . . . . . . 302K,
. . . . . . . . syn413K (AAg))

. . . . ChinaHeilongjiangSaertuSWL174_C1_21M_2009_11_02 (
. . . . . . . . GISAID HA EPI256402
. . . . . . . . GISAID Isolate EPI_ISL_74633
. . . . . . . . 2 Polymorphisms (0 Amino and 2 Silent)
. . . . . . . . syn175E (GAg) [avH1N1],
. . . . . . . . syn541C (TGt) [Emergent H7N9])

. . . . ChinaHeilongjiangSWL1_E1_18M_2009_07_13 (
. . . . . . . . GISAID HA EPI253374
. . . . . . . . GISAID Isolate EPI_ISL_73577
. . . . . . . . 4 Polymorphisms (3 Amino and 1 Silent)
. . . . . . . . 5K mix wt [Emergent H7N9],
. . . . . . . . . . . . . . . . . [H6N1, H9N2, H10N7],
. . . . . . . . syn108L (cTG) [H5N1],
. . . . . . . . . . . . . . . . . . [avH1N1farm],
. . . . . . . . 208K [H7N9],
. . . . . . . . . . . . [avH3N2],
. . . . . . . . . . . . [avH1N1farm],
. . . . . . . . 414I [H9N2],
. . . . . . . . . . . . [avH3N2],
. . . . . . . . . . . . [H6N1],
. . . . . . . . . . . . [H13N2])


NA Polymorphisms

. . . . ChinaHeilongjiangLongshaSWL1181_C3_3M_2011_04_08 (
. . . . . . . . GISAID NA EPI330848
. . . . . . . . GISAID Isolate EPI_ISL_94652
. . . . . . . . 9 Polymorphisms (3 Amino and 6 Silent)
. . . . . . . . 44S,
. . . . . . . . syn67V (GTc),
. . . . . . . . syn217K (AAa),
. . . . . . . . syn240T (ACc),
. . . . . . . . 241I,
. . . . . . . . syn360G (GGa),
. . . . . . . . 369K,
. . . . . . . . syn377P (CCa),
. . . . . . . . syn378N (AAt))

. . . . ChinaHeilongjiangXiangfangSWL1528_E2_2M_2011_03_04 (
. . . . . . . . GISAID NA EPI330672
. . . . . . . . GISAID Isolate EPI_ISL_94630
. . . . . . . . 7 Polymorphisms (3 Amino and 4 Silent)
. . . . . . . . 44S,
. . . . . . . . syn168S (TCa),
. . . . . . . . syn240T (ACc),
. . . . . . . . 241I,
. . . . . . . . 369K,
. . . . . . . . syn377P (CCa),
. . . . . . . . syn378N (AAt))

. . . . ChinaHeilongjiangXiangyangSWL196_C2_3M_2011_03_03 (
. . . . . . . . GISAID NA EPI330299
. . . . . . . . GISAID Isolate EPI_ISL_94579
. . . . . . . . 4 Polymorphisms (1 Amino and 3 Silent)
. . . . . . . . 20V,
. . . . . . . . syn238C (TGt),
. . . . . . . . syn315G (GGg),
. . . . . . . . syn446C (TGc))

. . . . ChinaHeilongjiangXiangfang196_C2C1_2011_03_03 (
. . . . . . . . GISAID NA EPI320019
. . . . . . . . GISAID Isolate EPI_ISL_90926
. . . . . . . . 5 Polymorphisms (1 Amino and 4 Silent)
. . . . . . . . 20V,
. . . . . . . . syn238C (TGt),
. . . . . . . . syn315G (GGg),
. . . . . . . . syn429G (GGa) mix wt,
. . . . . . . . syn446C (TGc))

. . . . ChinaHeilongjiangXiangfang191_E1E3_2011_01_08 (
. . . . . . . . GISAID NA EPI325575
. . . . . . . . GISAID Isolate EPI_ISL_93610
. . . . . . . . 9 Polymorphisms (4 Amino and 5 Silent)
. . . . . . . . 44S,
. . . . . . . . syn171N (AAt),
. . . . . . . . syn237S (TCc) mix wt,
. . . . . . . . syn240T (ACc),
. . . . . . . . 241I,
. . . . . . . . 369K,
. . . . . . . . syn377P (CCa),
. . . . . . . . syn378N (AAt),
. . . . . . . . 412Q mix wt)

. . . . ChinaHeilongjiangLongshaSWL19_C4_27F_2010_01_13 (
. . . . . . . . GISAID NA EPI258043
. . . . . . . . GISAID Isolate EPI_ISL_75039
. . . . . . . . 4 Polymorphisms (1 Amino and 3 Silent)
. . . . . . . . 48K,
. . . . . . . . syn247S (AGc),
. . . . . . . . syn350S (TCg),
. . . . . . . . syn372E (GAa))

. . . . ChinaHeilongjiangJianhuaSWL18_C4_11M_2010_01_09 (
. . . . . . . . GISAID NA EPI258039
. . . . . . . . GISAID Isolate EPI_ISL_75038
. . . . . . . . 6 Polymorphisms (1 Amino and 5 Silent)
. . . . . . . . syn50N (AAc),
. . . . . . . . 74I [Emergent H7N9],
. . . . . . . . syn205V (GTa),
. . . . . . . . syn315G (GGg),
. . . . . . . . syn443I (ATc),
. . . . . . . . syn446C (TGc))

. . . . ChinaHeilongjiangXiangfangSWL1970_C2_20F_2009_12_3 0 (
. . . . . . . . GISAID NA EPI257579
. . . . . . . . GISAID Isolate EPI_ISL_74923
. . . . . . . . 6 Polymorphisms (0 Amino and 6 Silent)
. . . . . . . . syn41G (GGa),
. . . . . . . . syn71N (AAt),
. . . . . . . . syn125S (TCt),
. . . . . . . . syn315G (GGg),
. . . . . . . . syn398E (GAa),
. . . . . . . . syn411E (GAg))

. . . . ChinaHeilongjiangLongshaSWL1424_C1_22F_2009_12_19 (
. . . . . . . . GISAID NA EPI257583
. . . . . . . . GISAID Isolate EPI_ISL_74924
. . . . . . . . 2 Polymorphisms (1 Amino and 1 Silent)
. . . . . . . . 269I,
. . . . . . . . syn392D (GAc))

. . . . ChinaHeilongjiangJianhuaSWL1574_C1_4F_2009_12_14 (
. . . . . . . . GISAID NA EPI257455
. . . . . . . . GISAID Isolate EPI_ISL_74892
. . . . . . . . 4 Polymorphisms (0 Amino and 4 Silent)
. . . . . . . . syn160S (AGt),
. . . . . . . . syn299S (TCa),
. . . . . . . . syn370G (GGc),
. . . . . . . . syn407V (GTc))

. . . . ChinaHeilongjiangSaertuSWL174_C1_21M_2009_11_02 (
. . . . . . . . GISAID NA EPI256401
. . . . . . . . GISAID Isolate EPI_ISL_74633
. . . . . . . . 1 Polymorphisms (0 Amino and 1 Silent)
. . . . . . . . syn345G (GGt))

. . . . ChinaHeilongjiangSWL1_E1_18M_2009_07_13 (
. . . . . . . . GISAID NA EPI253373
. . . . . . . . GISAID Isolate EPI_ISL_73577
. . . . . . . . 0 Polymorphisms (0 Amino and 0 Silent)

H7N9 Influenza Hemagglutinin and Neuraminidase Segments elucidated at 2013-05-03-01_00_40_588800 by GeneWurx see.PolyDetector v0, Copyright 2007-2013

We acknowledge the authors, originating and submitting laboratories of the sequences from GenBank & from GISAID’s EpiFlu™ Database on which this research is based. An additional list is detailed in the linked PDF entitled "GISAID_Citations_H5N1_2011" at Is H7N9 Spreading from Human to Human in China? Post#164

GISAID Citations

• GeneWurx Cross Serotype Homology Analysis, Open-Access, Full-Text version
• Human Emergent H7N9 from Zhejiang Province
• Environment Emergent H7N9 from Zhejiang
• China - H7N9 Human Isolates on Deposit at GISAID, Comprehensive Genetics Discussion