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  • Indonesia scientist says 1/5th of stray cats carry bird flu virus

    Indonesia scientist says 1/5th of stray cats carry bird flu virus
    Monday January 15, 3:54 PM

    (Kyodo) - About 100 of 500 stray cats surveyed in Indonesia were carrying the H5N1 bird flu virus, a local scientist said Monday.

    C.A. Nidom, who first reported that bird flu had entered Indonesia in 2003 but was ignored by the government, told Kyodo News the finding was based on his research funded by the Ministry of National Education and conducted on Java Island and in Lampung Province of Sumatra Island from September to December last year.

    "I will bring the results of my research to the Institute of Medical Science of the University of Tokyo next month for further tests," he said by telephone from Saudi Arabia.

    "I'm worried that the virus will be more easily transmitted to humans because the body temperature of mammals like cats is similar to that of humans," he added.

    He took blood samples from cats living around wet markets that sell chickens and hospitals designated for bird flu patients in the East Java provincial capital Surabaya, the Central Java provincial capital Semarang, West Java's Bandung, Lampung's Bandarlampung, and Jakarta and its suburb Tangerang.

    Nidom, a molecular biology expert at the state-run University of Airlangga, said the results were reported to the Health Ministry, but they have not been published and followed up on.

    I Nyoman Kandun, director for disease control and environmental health at the Health Ministry, said he has not received any information about the results of the research by Nidom, who is also a member of a government-sanctioned commission on bird flu control and preparedness.

    There are many unproven "rumors" about bird flu, Kandun said.

    The education ministry has allocated about 300 million rupiah (about $32,500) for bird flu research in fiscal 2006 and 2007.

    After no bird flu cases among humans were recorded in the country for three months, new cases began to emerge with the deaths of four people in as many days last week.

    Another patient, the 18-year-old son of a 38-year-old woman who died last week, has also tested positive for bird flu, marking the country's first bird flu cluster this year. The son is still being treated in hospital.

    Since bird flu began to hit Indonesia in mid-2003, up to 15 million infected fowl have died in 224 regencies in 30 of the country's 33 provinces.

    The government said 16 of the 30 provinces are considered to be free of bird flu, having had no cases in the last six months.

    World Health Organization statistics as of last Friday showed that bird flu has infected 265 people in 10 countries since its emergence in December 2003, with 159 of them having died, among them 59 Indonesians. That did not take account of the two who died late Friday and early Saturday.

    Indonesia's lead is followed by Vietnam with 42 fatalities and Thailand with 17. The other affected countries are Azerbaijan, Cambodia, China, Djibouti, Egypt, Iraq and Turkey.

    ...when you have eliminated the impossible, whatever remains, however improbable, must be the truth. - Sherlock Holmes

  • #2
    Re: Indonesia scientist says 1/5th of stray cats carry bird flu virus

    This is a confirmation of a report some time ago talking about "hundreds" of cats tested positive in Indonesia.

    ?Addressing chronic disease is an issue of human rights ? that must be our call to arms"
    Richard Horton, Editor-in-Chief The Lancet

    ~~~~ Twitter:@GertvanderHoek ~~~ GertvanderHoek@gmail.com ~~~

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    • #3
      Re: Indonesia scientist says 1/5th of stray cats carry bird flu virus

      Niman has talked about a "mammalian" reservior in Indonesia.

      http://www.flutrackers.com/forum/sho...ght=niman+cats

      H5N1 in Cats in Indonesia
      Recombinomics Commentary
      October 7, 2006

      A study conducted by the Indonesian Environment Information Center (PILI) in Yogyakarta found that stray cats had caught the H5N1 virus through contact with infected poultry at traditional markets.

      The above comments provide additional evidence implicating an alternative source of H5N1 human infections in Indonesia. Recently, Indonesia summarized the results of poultry tests by a WHO affiliated lab in Australia. Concerns had been voiced in an H5N1 meeting in Jakarta in June because the sequences from the vast majority of human cases on Java did not match the poultry H5N1 collected between 2003 and 2005. Consequently, 91 poultry samples were sent to Australia for virus isolation and sequencing. The samples were from collections between September 2005 and March 2006 and failed to match Java poultry isolates with most of the sequences from patients.

      All but one of the human isolates from patients on Java had a novel cleavage site, RESRRKKR, as well as a number of associated changes in all 8 gene segments that readily distinguished the human sequences from the poultry sequence (see green sequences in lower branch). One duck from Indramayu had the novel cleavage site, but that duck isolates had additional changes, including a silent change in the cleavage site, which was found in only a small subset of human isolates. The vast majority of human isolates, including those from Indramayu, failed to match the duck sequences. Two matching sequences were found in chickens in central Sumatra, but the match failure on Java, coupled with the almost universal matching of human sequences, including the first sequence isolate in July 2005 as well as isolates from a wide range of geographical locations, including East Java, suggested human infections were largely due to H5N1 in a reservoir other than poultry.

      The only match on Java of the human sequences was from a throat swab of a cat. A/feline/Indonesia/CDC1/2006(H5N1), from Jakarta on January 22, 2006. H5N1 has also been detected in swine in Indonesia, but the swine sequences, including the HA cleavage site, did not match the human sequences. The discovery of more H5N1 in cats in Indonesia raises the possibility that the cats are also in contact with an alternate reservoir.

      Sequence data on H5N1 from cats, and ?infected poultry in traditional markets?, including those in and around Jakarta, where most of the reported human cases have been located, would help resolve the role of cats in H5N1 transmission.

      Media Sources

      Phylogenetic Trees

      http://www.recombinomics.com/News/10...esia_Cats.html

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      • #4
        Re: Indonesia scientist says 1/5th of stray cats carry bird flu virus

        What about rabbits in Indonesia? Since they're known H5N1 carriers elsewhere, anything similar is suspect.

        It seems they're pushing rabbit meat as an industry. see Indonesian Rabbit Conference at http://world-rabbit-science.org/IB-Conf.htm It seems Indo is a primary SE ASian rabbit producer - see http://www.mybunnyfarm.com/science/ch1.htm.

        also from http://www.animalinfo.org/species/nesonets.htm...

        The Sumatran rabbit weighs about 1.5 kg (3.3 lb) and lives only in remote mountain forest. It is completely nocturnal, hiding during the day in dark places at the base of trees, in burrows (not of its own making), or holes in the ground. This rabbit subsists on a diet of leaves and stalks from forest understory plants.

        The Sumatran rabbit apparently was never abundant anywhere in its range. It is restricted to montane forest in the Barisan Mountains, in west and southwest Sumatra, Indonesia, with one record in 1972 from Guning Leuser National Park in northwest Sumatra.

        .
        "The next major advancement in the health of American people will be determined by what the individual is willing to do for himself"-- John Knowles, Former President of the Rockefeller Foundation

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        • #5
          Re: Indonesia scientist says 1/5th of stray cats carry bird flu virus

          the problem is, where does the evolution happen ?
          We would need cat2cat or rabbit2rabbit too.
          cat2rabbit2cat2rabbit2...
          or such
          I'm interested in expert panflu damage estimates
          my current links: http://bit.ly/hFI7H ILI-charts: http://bit.ly/CcRgT

          Comment


          • #6
            Re: Indonesia scientist says 1/5th of stray cats carry bird flu virus

            Originally posted by gsgs
            the problem is, where does the evolution happen ?
            We would need cat2cat or rabbit2rabbit too.
            cat2rabbit2cat2rabbit2...
            or such
            or mig bird2duck2rabbit2cat2human !!!

            And put chickens in anywhere in the progression.

            Just like SARS - multiple mammalian species jumps.

            .
            "The next major advancement in the health of American people will be determined by what the individual is willing to do for himself"-- John Knowles, Former President of the Rockefeller Foundation

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            • #7
              Re: Indonesia scientist says 1/5th of stray cats carry bird flu virus

              are you sure for rabbits ? all sorts of rabbits ?
              I only have find : white rabbit of new zealand ( experiment in laboratory )

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              • #8
                Re: Indonesia scientist says 1/5th of stray cats carry bird flu virus

                newest Egyptian case - they raised rabbits that died. see http://www.flutrackers.com/forum/sho...bits#post58450

                Next post - 1918 flu killed rabbits in 36 hours.

                .
                "The next major advancement in the health of American people will be determined by what the individual is willing to do for himself"-- John Knowles, Former President of the Rockefeller Foundation

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                • #9
                  Re: Indonesia scientist says 1/5th of stray cats carry bird flu virus

                  This particular AI is setting records - first to kill it's reservoir species, first to kill...cats, marmots, mink, etc. I'd hate to use it's old habits as the definitive word.

                  .
                  "The next major advancement in the health of American people will be determined by what the individual is willing to do for himself"-- John Knowles, Former President of the Rockefeller Foundation

                  Comment


                  • #10
                    Re: Indonesia scientist says 1/5th of stray cats carry bird flu virus

                    The alert map mentions thousands of rabbits that have been dying in Russia at farms this month.

                    "There's a chance peace will come in your life - please buy one" - Melanie Safka
                    "The greatest way to live with honor in this world is to be what we pretend to be" - Socrates

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                    • #11
                      Re: Indonesia scientist says 1/5th of stray cats carry bird flu virus

                      Originally posted by AlaskaDenise
                      newest Egyptian case - they raised rabbits that died. see http://www.flutrackers.com/forum/sho...bits#post58450

                      Next post - 1918 flu killed rabbits in 36 hours.

                      .
                      Egyptian case was not confirmed (tested negative).

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                      • #12
                        Re: Indonesia scientist says 1/5th of stray cats carry bird flu virus

                        After more digging....perhaps a more qualified person than myself can explain this from http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum

                        Molecular mechanisms of serum resistance of human influenza H3N2 virus and their involvement in virus adaptation in a new host.

                        .H3N2 human influenza viruses that are resistant to horse, pig, or rabbit serum possess unique amino acid mutations in their hemagglutinin (HA) protein. ....The major inhibitory activity in rabbit serum was found to be a beta inhibitor with characteristics of mannose-binding lectins. Rabbit serum-resistant variants exhibited decreased sensitivity to this inhibitor due to the loss of a glycosylation sequon at positions 246 to 248 of the HA.
                        ----------------------

                        So are they saying that the status of positions 246 and 248 can determine whether an influenza can bind or not with rabbits? Since those are the same positions that are changing elsewhere, what are they implications?

                        .
                        "The next major advancement in the health of American people will be determined by what the individual is willing to do for himself"-- John Knowles, Former President of the Rockefeller Foundation

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                        • #13
                          Re: Indonesia scientist says 1/5th of stray cats carry bird flu virus

                          Originally posted by niman
                          Egyptian case was not confirmed (tested negative).
                          Thanks for that clarification.

                          .
                          "The next major advancement in the health of American people will be determined by what the individual is willing to do for himself"-- John Knowles, Former President of the Rockefeller Foundation

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                          • #14
                            Re: Indonesia scientist says 1/5th of stray cats carry bird flu virus

                            Based on my 2-3 weeks in Indonesia in 1988, travelling into the countryside in Java and Sulawesi, I report that I saw NO RABBITS being raised as food.

                            For me, what were remarkable were: dogs in cages near family homes, fish in private ponds on family estates, chickens ubiquitiously, but no rabbits.

                            Indonesians do not eat cats, and there were no monkeys offered tat I recollect at any of the wet markets I explored.

                            Comment


                            • #15
                              Re: Indonesia scientist says 1/5th of stray cats carry bird flu virus

                              Per capita rabbit consumption in Indonesia is .27 kg/year, as compared to .14 kg/yr in the US, .23 kg/yr in Canada, while in Italy it is 5.71 kg/yr, France is 2.76, and Malta is 8.89 kg/yr.


                              Rabbit is a permissable meat in Islam.

                              .
                              "The next major advancement in the health of American people will be determined by what the individual is willing to do for himself"-- John Knowles, Former President of the Rockefeller Foundation

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