Conserved epitopes

[Ganseerpel]

Several human peptide epitopes that have been described and characterized show evidence of remarkably little mutation over many generations of viral evolution. In the most recent outbreaks of H5N1 virus, some of these peptides are conserved in viruses isolated from human patients

<TABLE cellSpacing=0 cellPadding=0 width="100&#37;" border=0><TBODY><TR><TD vAlign=bottom colSpan=4>Table. Conservation of human NP and M1 epitopes between H1N1 PR8 and 3 human isolates of H5N1 viruses (A/Hong Kong/156/1997, A/Hong Kong/213/2003, and A/Vietnam/1203/2004)*

</TD></TR><TR><TD colSpan=4><HR noShade SIZE=1></TD></TR><TR><TD vAlign=bottom>Epitope
</TD><TD vAlign=bottom>HLA restriction
</TD><TD vAlign=bottom>PR8 sequence
</TD><TD vAlign=bottom>Conservation

</TD></TR><TR><TD colSpan=4><HR noShade SIZE=1></TD></TR><TR><TD vAlign=top>NP 383–391
</TD><TD vAlign=top>B*2705
</TD><TD vAlign=top>SRYWAIRTR
</TD><TD vAlign=top>3/3 identical

</TD></TR><TR><TD vAlign=top>NP 418–426
</TD><TD vAlign=top>B*3501
</TD><TD vAlign=top>LPFDRTTIM
</TD><TD vAlign=top>0/3 identical

</TD></TR><TR><TD vAlign=top>NP 44–52
</TD><TD vAlign=top>A*01
</TD><TD vAlign=top>CTELKLSDY
</TD><TD vAlign=top>2/3 identical (156 Y9Q)

</TD></TR><TR><TD vAlign=top>NP 265–273
</TD><TD vAlign=top>A*03
</TD><TD vAlign=top>ILRGSVAHK
</TD><TD vAlign=top>3/3 identical

</TD></TR><TR><TD vAlign=top>NP 188–198
</TD><TD vAlign=top>A*1101
</TD><TD vAlign=top>TMVMELVRMIK
</TD><TD vAlign=top>3/3 V7I mutation

</TD></TR><TR><TD vAlign=top>NP 380–388
</TD><TD vAlign=top>B*08
</TD><TD vAlign=top>ELRSRYWAI
</TD><TD vAlign=top>3/3 identical

</TD></TR><TR><TD vAlign=top>NP 174–184
</TD><TD vAlign=top>B*2705
</TD><TD vAlign=top>RRSGAAGAAVK
</TD><TD vAlign=top>2/3 identical (156 V10I)

</TD></TR><TR><TD vAlign=top>M1 58–66
</TD><TD vAlign=top>A*0201
</TD><TD vAlign=top>GILGFVFTL
</TD><TD vAlign=top>3/3 identical

</TD></TR><TR><TD vAlign=top>M1 27–35
</TD><TD vAlign=top>A*03
</TD><TD vAlign=top>RLEDVFAGK
</TD><TD vAlign=top>2/3 mutated (1203, 213 both R1K)

</TD></TR><TR><TD vAlign=top>M1 13–21
</TD><TD vAlign=top>A*1101
</TD><TD vAlign=top>SIIPSGPLK
</TD><TD vAlign=top>3/3 identical

</TD></TR></TBODY></TABLE>

Reference:
Cell-mediated Protection in Influenza Infection Paul G. Thomas,* Rachael Keating CDC Vol. 12, No. 1 January 2006