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Antigenic and genetic characteristics of H5N1 viruses and candidate H5N1 vaccine viruses developed for potential use as human vaccines
Re: Antigenic and genetic characteristics of H5N1 viruses and candidate H5N1 vaccine viruses developed for potential use as human vaccines
Is it just me...
I feel sub Clade 2.3 seems to be more prominent/active/getting more ink/etc. than it used to. Is it becoming more of a threat or is it the Indonesia political problems just leave us without 2.1 data?
2.2 exploded after Qinghai and obviously is big in terms of territory but was its perceived prominence just due to the fact it was heading west and became seen as more 'our problem' so got more than its fair share of (predominantly western) attention. I always thought of China as the real 'home' of flus and have been suspicious of extended periods of silence as being poor surveillance or poor reporting.
I feel sub Clade 2.3 seems to be more prominent/active/getting more ink/etc. than it used to. Is it becoming more of a threat or is it the Indonesia political problems just leave us without 2.1 data?
2.2 exploded after Qinghai and obviously is big in terms of territory but was its perceived prominence just due to the fact it was heading west and became seen as more 'our problem' so got more than its fair share of (predominantly western) attention. I always thought of China as the real 'home' of flus and have been suspicious of extended periods of silence as being poor surveillance or poor reporting.
Its movement into long range migratory birds in Japan (and Korea) has put it on the front page (and lack of data from China doesn't say much since it is an Olympic year)..
Re: Antigenic and genetic characteristics of H5N1 viruses and candidate H5N1 vaccine viruses developed for potential use as human vaccines
Thanks.
Do you think there is one section of the tree that is, genetically, significantly more active with high rates of recombination/reassortment compared to others and if so do these active points shift?
We use the H & N to name the serotypes but across the full 8 strands are there areas in the world with very rich diversity (high potential for radical changes with recombination) compared to others (that was my assumption behind the China = 'home' of flus comment)?
Thanks.
Do you think there is one section of the tree that is, genetically, significantly more active with high rates of recombination/reassortment compared to others and if so do these active points shift?
We use the H & N to name the serotypes but across the full 8 strands are there areas in the world with very rich diversity (high potential for radical changes with recombination) compared to others (that was my assumption behind the China = 'home' of flus comment)?
Each tree is for a single gene segment and has nothing to do with reassortment. The length of a branch reflects number of changes.
Re: Antigenic and genetic characteristics of H5N1 viruses and candidate H5N1 vaccine viruses developed for potential use as human vaccines
genbank.
give a counter-example !
for H5N1 we have reassortments with H6N1,H9N2 in China 2004
(paper mentioned earlier can't find the URL so quickly)
but no such reassortment outside China
when we count 4 strains outside China (Qinghai,Indo,Vietnam,
Fujian) then we should count 10-20 strains inside China
with same distance between strains/clades
See also the recent papers about human flu
(Holmes et.al full genome, Smith et.al HA)
but just only one isolate, it didn't spread. Dead end.
In China evolution and creation of new strains happen.
For H5N1 and human flu.
For other avian serotypes also outside China.
Reassortment and evolution in Canadian
mallards etc.
For birds however Eurasian and American strains
don't mix.
Detection of H7N2 in humans is VERY poor. In 2003 the H7N7 appeared to spread to 1000's based on H7 antibody, but the vast majority of those cases was NOT detected by PCR.
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