Spring Hill 10-year-old dies from flu complications

[Ronan Kelly]

Spring Hill 10-year-old dies from flu complications
Apr 5, 2013

SPRING HILL ? The 10-year-old Allendale Elementary student who had been hospitalized for more than two weeks after going into cardiac arrest following a flu diagnosis has died.
...

http://www.tennessean.com/article/20130405/WILLIAMSON12/130405030/2023/WILLIAMSON

[NS1]

Re: Spring Hill 10-year-old dies from flu complications

Spring Hill 10-year-old dies from flu complications
Apr 5, 2013

SPRING HILL ? The 10-year-old Allendale Elementary student who had been hospitalized for more than two weeks after going into cardiac arrest following a flu diagnosis has died.
...
http://www.tennessean.com/article/20...023/WILLIAMSON

Every flu season has a genetic lineage for each focal location.

The pH1N1 flashfire now occurring is not unexpected and should not be "deemed" as unpredictable. The seeds of virulence have been accumulating and demonstrating intermittent mortality like this 10 year old elementary student, someone's daughter, who went into heart failure.

These types of clinical outcomes should be reconsidered for importance by the public health and medical community.

[NS1]

Re: Spring Hill 10-year-old dies from flu complications

pH1N1 Genetic Sequence
Sparsity
for
Tennessee

Only two genetic sequences are on file from Tennessee during 2013 with none after March. Those distant sequences suggest a circulation pattern similar to Texas and New Mexico.

[NS1]

Re: Spring Hill 10-year-old dies from flu complications

pH1N1 Child Vaccine Escape
CDC Early 2013

Map - Active and Detailed

<div style="text-align: center;">
<hr style="width: 30%;" />41 Cases over 43 Sequences<hr style="width: 30%;" /></div>
Introduction

In the 30 days covering 2013-02-28 to 2013-03-29, the&nbsp;<span style="color: #783f04;"><b>United States CDC</b></span>&nbsp;released a total of 43&nbsp;<b><span style="color: #632423; font-family: &quot;Trebuchet MS&quot;;">pH1N1</span></b>&nbsp;sequences at&nbsp;<strong>GISAID&nbsp;</strong>on 41 human cases<strong>&nbsp;</strong>sampled from October 2012 to February 2013. Geographic surveillance includes&nbsp;<b>America,</b>&nbsp;<b>Africa, Asia </b>and<b> Russia.&nbsp;</b>Although&nbsp;<b><span style="color: #632423; font-family: &quot;Trebuchet MS&quot;;">pH1N1</span></b>&nbsp;in most locales during the&nbsp;2012-2013 season was the <b><span style="color: #783f04;">minority</span></b> serotype, the sequences in this Analytic Report describe a high level of human-infective diversity and an ease of avian genetic acquisition, including multiple instances demonstrating concentrated transport of <b><span style="color: #660000;">High-CFR</span></b>&nbsp;<b><span style="color: #632423; font-family: &quot;Trebuchet MS&quot;;">pH1N1&nbsp;</span><span style="color: #783f04;">Upsilon</span></b> polymorphisms onto single sequences.

. . .

Read the Open-Access, Full-Text
Investigational Analytic
including Genetic Details

[NS1]

Re: Spring Hill 10-year-old dies from flu complications

pH1N1 Genetic Sequence
Sparsity
for
Tennessee

Only two genetic sequences are on file from Tennessee during 2013 with none after March. Those distant sequences suggest a circulation pattern similar to Texas and New Mexico.

pH1N1 TamiFlu Resistance

The most recent Tennessee sequence, sampled from a 53 year old woman in March 2013, is Drug Resistant (TmX275 onto a very common Neuraminidase) and displays CrossClade tendencies with Emergent H7N9 homology on the Hemagglutinin.

The Neuraminidase lineage is common; The CrossClade Hemagglutinin lineage was widespread to geographies supporting avian inclusions, e.g. Brazil [EPI484739] and Costa Rica [EPI484980].