Discussion ? Why is China is not reporting details of recent H7N9 deaths? (Part 1)

[AlaskaDenise]

Re: Discussion ? Why is China is not reporting details of recent H7N9 deaths?

It seems to me, that there should still be more cases of H7N9 if they were diagnosing and reporting them. It 'died out' too fast for me to think that is believable. Statements from CDC and WHO and other governmental agencies seemed fairly dire regarding H7N9. Now it is suddenly gone? Poof! .........

Don't forget that human H5N1 was essentially supressed after 1997 (by killing all poultry in HK) until 2003 (except for a smattering of cases in 1998 and 2001). So it is possible to have a true "slowdown". Even avoiding sick people can slow the spread - so the speed may be reduced, but I doubt it's gone.

.

[IanM]

Re: Discussion ? Why is China is not reporting details of recent H7N9 deaths?

I'll throw in my own paper since interference is popping up....

Do rhinoviruses reduce the probability of viral co-detection during acute
respiratory tract infections?
Greer et al in J Clinical Virology (2009) 45:p10-15.

Background: Human rhinoviruses (HRVs) are often concurrently detected with other viruses found in the respiratory tract because of the high total number of HRV infections occurring throughout the year. This feature has previously relegated HRVs to being considered passengers in acute respiratory infections.
HRVs remain poorly characterized and are seldom included as a target in diagnostic panels despite their pathogenic potential, infection-associated healthcare expenditure and relatively unmoderated elicitation of an antiviral state.

Objectives: To test the hypothesis that respiratory viruses are proportionately more or less likely to cooccur,particularly the HRVs.

Study design: Retrospective PCR-based analyses of 1247 specimens for 17 viruses, including HRV strains,identified 131 specimens containing two or more targets.We investigated the proportions of co-detections and compared the proportion of upper vs. lower respiratory tract presentations in the HRV positive group.
Both univariate contingency table and multivariate logistic regression analyses were conducted to identify trends of association among the viruses present in co-detections.

Results: Many of the co-detections occurred in patterns. In particular, HRV detection was associated with a reduced probability of detecting human adenoviruses, coronaviruses, bocavirus, metapneumovirus, respiratory syncytial virus, parainfluenza virus, influenza A virus, and the polyomaviruses KIPyV and WUPyV (p≤0.05). No single HRV species nor cluster of particular strains predominated.

Conclusions: HRVs were proportionately under-represented among viral co-detections. For some period, HRVs may render the host less likely to be infected by other viruses.

[sharon sanders]

Re: Discussion ? Why is China is not reporting details of recent H7N9 deaths?

Thank you IanM and Welcome!

[sharon sanders]

Re: Discussion ? Why is China is not reporting details of recent H7N9 deaths?

added reference to above:

J Clin Virol. 2009 May;45(1):10-5. doi: 10.1016/j.jcv.2009.03.008. Epub 2009 Apr 18.
Do rhinoviruses reduce the probability of viral co-detection during acute respiratory tract infections?

Greer RM, McErlean P, Arden KE, Faux CE, Nitsche A, Lambert SB, Nissen MD, Sloots TP, Mackay IM.
Source: School of Veterinary Science, University of Queensland, St Lucia, Queensland, Australia.

http://www.ncbi.nlm.nih.gov/pubmed/19376742

[gsgs]

Re: Discussion ? Why is China is not reporting details of recent H7N9 deaths?

thanks. I saw, some institutes are regularly testing for HRV now
(among others)

would it be practicable to deliberately infect yourself with HRN at the
height of a hypothetical severe flu-wave so to reduce flu-risk ?

Maybe for HCWs ... only get those with HRN to the flu-patients


-------------------------------------------------------------
they had weekly amounts of several virii here until 2011

http://www.pid-ari.net/index.htm

I wished, there were more such surveillance sites
(are there ?)

[Michael Coston]

Re: Discussion ? Why is China is not reporting details of recent H7N9 deaths?

Great to see you here, IanM!

[IanM]

Re: Discussion ? Why is China is not reporting details of recent H7N9 deaths?

Thanks all. Nice to be here - nicer to be in bed though at this hour!

Best affiliation for that paper is Queensland Paediatric Infectious Diseases (QPID) Laboratory Queensland Children’s Medical Research Institute (QCMRI), UQ.

Practical to self-inoculate with an HRV? I suspect it would be (not for those with a predisposition to severe disease following HRV infection - such as those with asthma [paed nurse-nuh], COPD etc). There are also data that the LAIV provided "off target" protection against other respiratory viruses as did similar live attenuated viral formulations used in early enterovirus vaccines some decades ago. Interestingly the trivalent flu vaccines may not elicit the same response (Cowley et al a year or two back). The mechanism is, broadly speaking, interferon-based (the name interferon originates form experiments into interference between viruses).

I'm looking at this in the lab in cell cultures first.

[gsgs]

Re: Discussion ? Why is China is not reporting details of recent H7N9 deaths?

getting offtopicer
also this from PLOS:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522717/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522717/table/pone-0051491-t001/

children,Stockholm,2009
H1:17% , H1 given HRV:4% , ~4 times reduction

[Shannon Bennett]

Re: Discussion ? Why is China is not reporting details of recent H7N9 deaths?

Welcome Ian! You must be tired as it is very early in Australia.

Well that preventive pre-infection leaves me out as I am around little children and I have asthma. Darn. Back to hand-washing when the time comes. Well that and a few herbal concoctions.