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Gestational Influenza and Bipolar Disorder in Adult Offspring ONLINE FIRST
Raveen Parboosing, MBChB, MMed, FCPath(SA)(Viro), MS; Yuanyuan Bao, MS; Ling Shen, PhD; Catherine A. Schaefer, PhD; Alan S. Brown, MD, MPH
JAMA Psychiatry. 2013;():1-8. doi:10.1001/jamapsychiatry.2013.896.
Published online May 8, 2013
Importance Gestational influenza has been associated previously with schizophrenia in offspring, but the relationship between this exposure and bipolar disorder (BD) is unclear. The identification of gestational influenza as a risk factor for BD may have potential for preventive approaches.
Objective To test the hypothesis that maternal influenza during pregnancy is related to BD among offspring.
Design Nested case-control study of a population-based birth cohort from the Child Health and Development Study (CHDS). From January 1, 1959, through December 31, 1966, the CHDS recruited nearly all pregnant women receiving obstetric care from the Kaiser Permanente Medical Care Plan, Northern California Region (KPNC). Data on treated maternal influenza from the CHDS were used. Potential cases with BD from the cohort were identified by database linkages of identifiers among the CHDS, Kaiser Permanente database, and a large county health care database; by a mailed questionnaire to the CHDS cohort with subsequent interviews; and from an earlier psychiatric follow-up study on this birth cohort.
Setting The CHDS, Kaiser Permanente, and county health care databases.
Participants Cases of BD (n = 92) confirmed by structured research interviews and consensus diagnosis among the 214 subjects (48% of those ascertained) who participated and control subjects (n = 722) matched on date of birth, sex, and membership in KPNC or residence in Alameda County.
Exposures Influenza
Raveen Parboosing, MBChB, MMed, FCPath(SA)(Viro), MS; Yuanyuan Bao, MS; Ling Shen, PhD; Catherine A. Schaefer, PhD; Alan S. Brown, MD, MPH
JAMA Psychiatry. 2013;():1-8. doi:10.1001/jamapsychiatry.2013.896.
Published online May 8, 2013
Importance Gestational influenza has been associated previously with schizophrenia in offspring, but the relationship between this exposure and bipolar disorder (BD) is unclear. The identification of gestational influenza as a risk factor for BD may have potential for preventive approaches.
Objective To test the hypothesis that maternal influenza during pregnancy is related to BD among offspring.
Design Nested case-control study of a population-based birth cohort from the Child Health and Development Study (CHDS). From January 1, 1959, through December 31, 1966, the CHDS recruited nearly all pregnant women receiving obstetric care from the Kaiser Permanente Medical Care Plan, Northern California Region (KPNC). Data on treated maternal influenza from the CHDS were used. Potential cases with BD from the cohort were identified by database linkages of identifiers among the CHDS, Kaiser Permanente database, and a large county health care database; by a mailed questionnaire to the CHDS cohort with subsequent interviews; and from an earlier psychiatric follow-up study on this birth cohort.
Setting The CHDS, Kaiser Permanente, and county health care databases.
Participants Cases of BD (n = 92) confirmed by structured research interviews and consensus diagnosis among the 214 subjects (48% of those ascertained) who participated and control subjects (n = 722) matched on date of birth, sex, and membership in KPNC or residence in Alameda County.
Exposures Influenza
