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Vaccine. 2013 May 17. pii: S0264-410X(13)00589-6. doi: 10.1016/j.vaccine.2013.05.011. [Epub ahead of print]
Seasonal influenza vaccine effectiveness in pre- and full-term children aged 6-23 months over multiple seasons.
Shen S, Campitelli MA, Calzavara A, Guttmann A, Kwong JC.
Source
Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.
Abstract
INTRODUCTION:
This study aimed to determine the effectiveness of seasonal influenza vaccine in pre- and full-term children aged 6-23 months.
METHODS:
We examined a cohort of 683,354 young children (7.7% preterm) over five influenza seasons (2004-2005 to 2008-2009) in Ontario, Canada. Vaccine effectiveness was estimated using influenza-coded ambulatory visits during virologically-confirmed influenza season periods as the outcome and multivariable Cox proportional hazards modeling.
RESULTS:
Full vaccination was associated with a 19% reduction in influenza-coded ambulatory visits (HR=0.81; 95% CI, 0.68-0.97) in all children, and an 18% reduction in full-term children (HR=0.82; 95% CI, 0.68-0.99). We did not find significant vaccine effectiveness for preterm children. No benefit was found for partial vaccination.
CONCLUSIONS:
In children younger than two years, only full influenza vaccination is associated with reduced influenza-coded ambulatory visits. Since the effectiveness of influenza vaccination in preterm children remains uncertain, further study of this highly vulnerable population is warranted.
Copyright ? 2013. Published by Elsevier Ltd.
PMID:
23688524
[PubMed - as supplied by publisher]
Seasonal influenza vaccine effectiveness in pre- and full-term children aged 6-23 months over multiple seasons.
Shen S, Campitelli MA, Calzavara A, Guttmann A, Kwong JC.
Source
Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.
Abstract
INTRODUCTION:
This study aimed to determine the effectiveness of seasonal influenza vaccine in pre- and full-term children aged 6-23 months.
METHODS:
We examined a cohort of 683,354 young children (7.7% preterm) over five influenza seasons (2004-2005 to 2008-2009) in Ontario, Canada. Vaccine effectiveness was estimated using influenza-coded ambulatory visits during virologically-confirmed influenza season periods as the outcome and multivariable Cox proportional hazards modeling.
RESULTS:
Full vaccination was associated with a 19% reduction in influenza-coded ambulatory visits (HR=0.81; 95% CI, 0.68-0.97) in all children, and an 18% reduction in full-term children (HR=0.82; 95% CI, 0.68-0.99). We did not find significant vaccine effectiveness for preterm children. No benefit was found for partial vaccination.
CONCLUSIONS:
In children younger than two years, only full influenza vaccination is associated with reduced influenza-coded ambulatory visits. Since the effectiveness of influenza vaccination in preterm children remains uncertain, further study of this highly vulnerable population is warranted.
Copyright ? 2013. Published by Elsevier Ltd.
PMID:
23688524
[PubMed - as supplied by publisher]
