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J Formos Med Assoc. The emerging novel Middle East respiratory syndrome coronavirus: The ?knowns? and ?unknowns?
[Source: Journal of the Formosan Medical Association, full page: (LINK). Abstract, edited.]
Journal of the Formosan Medical Association
The emerging novel Middle East respiratory syndrome coronavirus: The ?knowns? and ?unknowns?
Jasper Fuk-Woo Chan, Susanna Kar-Pui Lau, Patrick Chiu-Yat Woo
Received 16 April 2013; received in revised form 13 May 2013; accepted 14 May 2013. published online 23 July 2013.
Corrected Proof
Abstract
A novel lineage C betacoronavirus, originally named human coronavirus EMC/2012 (HCoV-EMC) and recently renamed Middle East respiratory syndrome coronavirus (MERS-CoV), that is phylogenetically closely related to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5, which we discovered in 2007 from bats in Hong Kong, has recently emerged in the Middle East to cause a severe acute respiratory syndrome (SARS)-like infection in humans. The first laboratory-confirmed case, which involved a 60-year-old man from Bisha, the Kingdom of Saudi Arabia (KSA), who died of rapidly progressive community-acquired pneumonia and acute renal failure, was announced by the World Health Organization (WHO) on September 23, 2012. Since then, a total of 70 cases, including 39 fatalities, have been reported in the Middle East and Europe. Recent clusters involving epidemiologically-linked household contacts and hospital contacts in the Middle East, Europe, and Africa strongly suggested possible human-to-human transmission. Clinical and laboratory research data generated in the past few months have provided new insights into the possible animal reservoirs, transmissibility, and virulence of MERS-CoV, and the optimal laboratory diagnostic options and potential antiviral targets for MERS-CoV-associated infection.
Keywords: coronavirus, EMC, human, Middle East, SARS
PII: S0929-6646(13)00177-0
doi:10.1016/j.jfma.2013.05.010
? 2013 Published by Elsevier Inc.
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Journal of the Formosan Medical Association
The emerging novel Middle East respiratory syndrome coronavirus: The ?knowns? and ?unknowns?
Jasper Fuk-Woo Chan, Susanna Kar-Pui Lau, Patrick Chiu-Yat Woo
Received 16 April 2013; received in revised form 13 May 2013; accepted 14 May 2013. published online 23 July 2013.
Corrected Proof
Abstract
A novel lineage C betacoronavirus, originally named human coronavirus EMC/2012 (HCoV-EMC) and recently renamed Middle East respiratory syndrome coronavirus (MERS-CoV), that is phylogenetically closely related to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5, which we discovered in 2007 from bats in Hong Kong, has recently emerged in the Middle East to cause a severe acute respiratory syndrome (SARS)-like infection in humans. The first laboratory-confirmed case, which involved a 60-year-old man from Bisha, the Kingdom of Saudi Arabia (KSA), who died of rapidly progressive community-acquired pneumonia and acute renal failure, was announced by the World Health Organization (WHO) on September 23, 2012. Since then, a total of 70 cases, including 39 fatalities, have been reported in the Middle East and Europe. Recent clusters involving epidemiologically-linked household contacts and hospital contacts in the Middle East, Europe, and Africa strongly suggested possible human-to-human transmission. Clinical and laboratory research data generated in the past few months have provided new insights into the possible animal reservoirs, transmissibility, and virulence of MERS-CoV, and the optimal laboratory diagnostic options and potential antiviral targets for MERS-CoV-associated infection.
Keywords: coronavirus, EMC, human, Middle East, SARS
PII: S0929-6646(13)00177-0
doi:10.1016/j.jfma.2013.05.010
? 2013 Published by Elsevier Inc.
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