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J Virol. Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist.

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  • J Virol. Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist.

    [Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]


    J Virol. 2013 Sep 11. [Epub ahead of print]

    Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist.

    Niemeyer D, Zillinger T, Muth D, Zielecki F, Horvath G, Suliman T, Barchet W, Weber F, Drosten C, M?ller MA.

    Source: Institute of Virology, University of Bonn Medical Center, Bonn/Germany.


    Abstract

    Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory infection with as yet unclear epidemiology. We previously showed that MERS-CoV counteracts parts of the innate immune response in human bronchiolar cells. Here we analyzed accessory proteins 3, 4a, 4b and 5 for their abilities to inhibit the type I interferon response. Accessory protein 4a was found to block interferon induction at the level of MDA5 activation presumably by direct interaction with double-stranded RNA.


    PMID: 24027320 [PubMed - as supplied by publisher]


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