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Clin Infect Dis. Virological, Serological, and Anti-Viral Studies of an Imported Human Case of Avian-Influenza A [H7N9] Virus in Taiwan
[Source: Clinical Infectious Diseases, full page: (LINK). Abstract, edited.]
Virological, Serological, and Anti-Viral Studies of an Imported Human Case of Avian-Influenza A [H7N9] Virus in Taiwan
Pi-Han Lin 1,#, Tai-Ling Chao 1,#, Shuenn-Wen Kuo 2, Jann-Tay Wang 3, Chien-Ching **** 3, Huan-Chun Lin 1, Zong-Yu Yang 1, Shu-Yuan Ho 4, Chun-Kai Chang 1, Ming-Siang Huang 1, Hui-Hou Chen 4, Yee-Chun Chen 3, Hong-Shiee Lai 2, Sui-Yuan Chang 1,4, Shan-Chwen Chang 3,*, and Pan-Chyr Yang 3
Author Affiliations: <SUP>1</SUP>Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan <SUP>2</SUP>Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan <SUP>3</SUP>Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan <SUP>4</SUP>Department of Laboratory Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
*Corresponding author: Dr. Shan-Chwen Chang, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, 7 Chung-Shan South Road, Taipei, Taiwan, E-mail: changsc@ntu.edu.tw, Tel.: +886-2-23123456 ext. 61964, Fax: +886-2- 23217522
Alternative corresponding author: Dr. Sui-Yuan Chang, Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, 1 Chang-Te Street, Taipei, Taiwan, E-mail: sychang@ntu.edu.tw, Tel.: +886-2-23123456 ext. 66908, Fax: +886-2- 23711574
# Dr PH Lin and TL Chao contributed equally to this work.
<CITE><ABBR>Clin Infect Dis.</ABBR> (2013) - doi: 10.1093/cid/cit638 - </CITE>First published online: September 27, 2013
Abstract
We described the clinical course and virological characteristics of the first H7N9 case in a Taiwanese who had detectable viruses in the airway for 2 weeks, during which time oseltamivir-resistance-associated R292 K mutation rapidly emerged. Anti-H7N9 antibody was detected 21 days after onset of symptoms, when H7N9 viral load declined significantly.
Received June 6, 2013. Accepted September 10, 2013.
? The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
For Permissions, please e-mail: journals.permissions@oup.com.
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Virological, Serological, and Anti-Viral Studies of an Imported Human Case of Avian-Influenza A [H7N9] Virus in Taiwan
Pi-Han Lin 1,#, Tai-Ling Chao 1,#, Shuenn-Wen Kuo 2, Jann-Tay Wang 3, Chien-Ching **** 3, Huan-Chun Lin 1, Zong-Yu Yang 1, Shu-Yuan Ho 4, Chun-Kai Chang 1, Ming-Siang Huang 1, Hui-Hou Chen 4, Yee-Chun Chen 3, Hong-Shiee Lai 2, Sui-Yuan Chang 1,4, Shan-Chwen Chang 3,*, and Pan-Chyr Yang 3
Author Affiliations: <SUP>1</SUP>Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan <SUP>2</SUP>Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan <SUP>3</SUP>Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan <SUP>4</SUP>Department of Laboratory Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
*Corresponding author: Dr. Shan-Chwen Chang, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, 7 Chung-Shan South Road, Taipei, Taiwan, E-mail: changsc@ntu.edu.tw, Tel.: +886-2-23123456 ext. 61964, Fax: +886-2- 23217522
Alternative corresponding author: Dr. Sui-Yuan Chang, Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, 1 Chang-Te Street, Taipei, Taiwan, E-mail: sychang@ntu.edu.tw, Tel.: +886-2-23123456 ext. 66908, Fax: +886-2- 23711574
# Dr PH Lin and TL Chao contributed equally to this work.
<CITE><ABBR>Clin Infect Dis.</ABBR> (2013) - doi: 10.1093/cid/cit638 - </CITE>First published online: September 27, 2013
Abstract
We described the clinical course and virological characteristics of the first H7N9 case in a Taiwanese who had detectable viruses in the airway for 2 weeks, during which time oseltamivir-resistance-associated R292 K mutation rapidly emerged. Anti-H7N9 antibody was detected 21 days after onset of symptoms, when H7N9 viral load declined significantly.
Received June 6, 2013. Accepted September 10, 2013.
? The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
For Permissions, please e-mail: journals.permissions@oup.com.
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