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J Virol. H3 stalk-based chimeric hemagglutinin influenza virus constructs protect mice from H7N9 challenge
[Source: Journal of Virology, full page: (LINK). Abstract, edited.]
H3 stalk-based chimeric hemagglutinin influenza virus constructs protect mice from H7N9 challenge
Florian Krammer 1, Irina Margine 1,2, Rong Hai 1, Alexander Flood 3, Ariana Hirsh 1, Vadim Tsvetnitsky 3, Dexiang Chen 3 and Peter Palese 1,4*
Author Affiliations: <SUP>1</SUP>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA <SUP>2</SUP>Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA <SUP>3</SUP>PATH, Seattle, WA, USA <SUP>4</SUP>Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Published ahead of print 4 December 2013, doi: 10.1128/JVI.03183-13 <CITE>JVI.03183-13 </CITE>
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<CITE></CITE>ABSTRACT
The recent outbreak of H7N9 influenza virus infections in humans in China has raised concerns about the pandemic potential of this strain. Here we test the efficacy of H3-stalk based chimeric hemagglutinin universal influenza virus vaccine constructs to protect against H7N9 challenge in mice. Chimeric hemagglutinin constructs protected from viral challenge in the context of different administration routes, and a generic oil-in-water adjuvant similar to formulations licensed for use in humans.
FOOTNOTES
*To whom correspondence should be addressed: peter.palese@mssm.edu
Copyright ? 2013, American Society for Microbiology. All Rights Reserved.
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H3 stalk-based chimeric hemagglutinin influenza virus constructs protect mice from H7N9 challenge
Florian Krammer 1, Irina Margine 1,2, Rong Hai 1, Alexander Flood 3, Ariana Hirsh 1, Vadim Tsvetnitsky 3, Dexiang Chen 3 and Peter Palese 1,4*
Author Affiliations: <SUP>1</SUP>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA <SUP>2</SUP>Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA <SUP>3</SUP>PATH, Seattle, WA, USA <SUP>4</SUP>Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Published ahead of print 4 December 2013, doi: 10.1128/JVI.03183-13 <CITE>JVI.03183-13 </CITE>
<CITE></CITE>
<CITE></CITE>
<CITE></CITE>ABSTRACT
The recent outbreak of H7N9 influenza virus infections in humans in China has raised concerns about the pandemic potential of this strain. Here we test the efficacy of H3-stalk based chimeric hemagglutinin universal influenza virus vaccine constructs to protect against H7N9 challenge in mice. Chimeric hemagglutinin constructs protected from viral challenge in the context of different administration routes, and a generic oil-in-water adjuvant similar to formulations licensed for use in humans.
FOOTNOTES
*To whom correspondence should be addressed: peter.palese@mssm.edu
Copyright ? 2013, American Society for Microbiology. All Rights Reserved.
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