BMJ: Calculating the burden of disease of avian-origin H7N9 infections in China

[tetano]

BMJ Open 2014;4:e004189 doi:10.1136/bmjopen-2013-004189

Health economics

Calculating the burden of disease of avian-origin H7N9 infections in China

Xiaopeng Qi1,
Dong Jiang2,
Hongliang Wang3,
Dafang Zhuang2,
Jiaqi Ma1,
Jingying Fu2,4,
Jingdong Qu3,
Yan Sun5,
Shicheng Yu1,
Yujie Meng1,
Yaohuan Huang2,
Lanfang Xia1,
Yingying Li1,
Yong Wang2,
Guohua Wang5,
Ke Xu6,
Qun Zhang1,
Ming Wan1,
Xuemei Su1,
Gang Fu1,
George F Gao7

1National Center for Public Health Surveillance and Information Services, Chinese Center for Disease Control and Prevention, Beijing, China
2State Key Laboratory of Resources and Environmental Information System, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, China
3The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China
4University of Chinese Academy of Sciences, Beijing, China
5School of Public Health, Harbin Medical University, Harbin, China
6College of Geoscience and Surveying Engineering, China University of Mining & Technology (Beijing), Beijing, China
7Chinese Center for Disease Control and Prevention, Beijing, China

Correspondence to Dr Xiaopeng Qi; qixp{at}chinacdc.cn or Prof George F Gao; gaofu{at}chinacdc.cn

Received 9 October 2013
Revised 22 November 2013
Accepted 20 December 2013
Published 17 January 2014

Abstract

Objective A total of 131 cases of avian-originated H7N9 infection have been confirmed in China mainland from February 2013 to May 2013. We calculated the overall burden of H7N9 cases in China as of 31 May 2013 to provide an example of comprehensive burden of disease in the 21st century from an acute animal-borne emerging infectious disease.

Design We present an accurate and operable method for estimating the burden of H7N9 cases in China. The main drivers of economic loss were identified. Costs were broken down into direct (outpatient and inpatient examination and treatment) and indirect costs (cost of disability-adjusted life years (DALYs) and losses in the poultry industry), which were estimated based on field surveys and China statistical year book.

Setting Models were applied to estimate the overall burden of H7N9 cases in China.

Participants 131 laboratory-confirmed H7N9 cases by 31 May 2013.

Outcome measure Burden of H7N9 cases including direct and indirect losses.

Results The total direct medical cost was ?16 422 535 (US$2 627 606). The mean cost for each patient was ?10 117 (US$1619) for mild patients, ?139 323 (US$22 292) for severe cases without death and ?205 976 (US$32 956) for severe cases with death. The total cost of DALYs was ?17 356 561 (US$2 777 050). The poultry industry losses amounted to ?7.75 billion (US$1.24 billion) in 10 affected provinces and ?3.68 billion (USD$0.59 billion) in eight non-affected adjacent provinces.

Conclusions The huge poultry industry losses followed live poultry markets closing down and poultry slaughtering in some areas. Though the proportion of direct medical losses and DALYs losses in the estimate of H7N9 burden was small, the medical costs per case were extremely high (particularly for addressing the use of modern medical devices). A cost-effectiveness assessment for the intervention should be conducted in a future study.

full article

http://bmjopen.bmj.com/content/4/1/e004189.full

[Giuseppe]

Re: BMJ: Calculating the burden of disease of avian-origin H7N9 infections in China

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]


BMJ Open. 2014 Jan 17;4(1):e004189. doi: 10.1136/bmjopen-2013-004189.

Calculating the burden of disease of avian-origin H7N9 infections in China.

Qi X, Jiang D, Wang H, Zhuang D, Ma J, Fu J, Qu J, Sun Y, Yu S, Meng Y, Huang Y, Xia L, Li Y, Wang Y, Wang G, Xu K, Zhang Q, Wan M, Su X, Fu G, Gao GF.

Author information: National Center for Public Health Surveillance and Information Services, Chinese Center for Disease Control and Prevention, Beijing, China.


Abstract

OBJECTIVE:

A total of 131 cases of avian-originated H7N9 infection have been confirmed in China mainland from February 2013 to May 2013. We calculated the overall burden of H7N9 cases in China as of 31 May 2013 to provide an example of comprehensive burden of disease in the 21st century from an acute animal-borne emerging infectious disease.


DESIGN:

We present an accurate and operable method for estimating the burden of H7N9 cases in China. The main drivers of economic loss were identified. Costs were broken down into direct (outpatient and inpatient examination and treatment) and indirect costs (cost of disability-adjusted life years (DALYs) and losses in the poultry industry), which were estimated based on field surveys and China statistical year book.


SETTING:

Models were applied to estimate the overall burden of H7N9 cases in China.


PARTICIPANTS:

131 laboratory-confirmed H7N9 cases by 31 May 2013.


OUTCOME MEASURE:

Burden of H7N9 cases including direct and indirect losses.


RESULTS:

The total direct medical cost was ?16 422 535 (US$2 627 606). The mean cost for each patient was ?10 117 (US$1619) for mild patients, ?139 323 (US$22 292) for severe cases without death and ?205 976 (US$32 956) for severe cases with death. The total cost of DALYs was ?17 356 561 (US$2 777 050). The poultry industry losses amounted to ?7.75 billion (US$1.24 billion) in 10 affected provinces and ?3.68 billion (USD$0.59 billion) in eight non-affected adjacent provinces.


CONCLUSIONS:

The huge poultry industry losses followed live poultry markets closing down and poultry slaughtering in some areas. Though the proportion of direct medical losses and DALYs losses in the estimate of H7N9 burden was small, the medical costs per case were extremely high (particularly for addressing the use of modern medical devices). A cost-effectiveness assessment for the intervention should be conducted in a future study.


KEYWORDS:

Burden of diseases, H7N9, Health Economics


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