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I'm planning to show the mutation pictures for all segments
and some different HAs and NAs
for now I have segment 1 , PB2, which is separated between
Eurasia and North-America (and South-America) more than
the other segments.
It evolves separately since ~100 years
while segments 2 and 3 only are separated since ~ 50 years
when an Eurasian variant entered North America and replaced
the American strain which was similar to the 1918 virus
so bad human pandemics did happen, when North-American
and Eurasian strains did mix on a large basis.
An avian epizootic preceded the human pandemics
This could happen again, when/if Eurasian H5N1 establishes
in North America and mixes/reassorts with the American lineages
resulting in enhanced evolution and development of new influenza
viruses with pandemic potential
3 big groups and some smaller groups.
Eurasia 1, Eurasia 2, North America
(17G,South America,classical swine, )
I should add the continents and years and codon-positions of the
viruses to the graphics. I've done this before with bars to the right,
but maybe a color encoding is better ?!
The sorting is improved now with a TSP-solver
--------------------------------------------------------
it's not so clear to me whether the most recent common ancestor date
between the Eurasian and North-American strains in PB2 is really
~1900 . We have these periods of low-mutation-evolution in non-poultry birds (mallards)
And when I plot the #mutations against the index over time I don't get these
main-diagonal-line-like areas as usual.
The closest that I came to this "line-like" with subgroups of avian PB2s
was with the Australean viruses and HK from the 70s
The early ancestor viruses from 1949,1934,1956,1959,1963 were all not much closer
to the index as recent viruses. So, do those have today-living descendents at all ?
Where did the HK 70s viruses come from ?
and some different HAs and NAs
for now I have segment 1 , PB2, which is separated between
Eurasia and North-America (and South-America) more than
the other segments.
It evolves separately since ~100 years
while segments 2 and 3 only are separated since ~ 50 years
when an Eurasian variant entered North America and replaced
the American strain which was similar to the 1918 virus
so bad human pandemics did happen, when North-American
and Eurasian strains did mix on a large basis.
An avian epizootic preceded the human pandemics
This could happen again, when/if Eurasian H5N1 establishes
in North America and mixes/reassorts with the American lineages
resulting in enhanced evolution and development of new influenza
viruses with pandemic potential
3 big groups and some smaller groups.
Eurasia 1, Eurasia 2, North America
(17G,South America,classical swine, )
I should add the continents and years and codon-positions of the
viruses to the graphics. I've done this before with bars to the right,
but maybe a color encoding is better ?!
The sorting is improved now with a TSP-solver
--------------------------------------------------------
it's not so clear to me whether the most recent common ancestor date
between the Eurasian and North-American strains in PB2 is really
~1900 . We have these periods of low-mutation-evolution in non-poultry birds (mallards)
And when I plot the #mutations against the index over time I don't get these
main-diagonal-line-like areas as usual.
The closest that I came to this "line-like" with subgroups of avian PB2s
was with the Australean viruses and HK from the 70s
The early ancestor viruses from 1949,1934,1956,1959,1963 were all not much closer
to the index as recent viruses. So, do those have today-living descendents at all ?
Where did the HK 70s viruses come from ?
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