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Neuer, Carbapenem- resistenter Keim aufgetaucht, der aus Indien eingeschleppt wird.
and (ii) because a novel enzyme, NDM-1 (New Delhi Metallo
Neuer, Carbapenem- resistenter Keim aufgetaucht, der aus Indien eingeschleppt wird.
Background
In January 2009 we issued a National Resistance Alert concerning carbapenemases in UK Enterobacteriaceae. This followed
consultation with ARHAI and stressed: (i) the growing number of producer isolates referred to the HPA’s Antibiotic Resistance
Monitoring & Reference Laboratory (ARMRL) (8 in all years to 2007; ultimately 21 in 2008); (ii) the diversity of these, variously
with metallo (VIM or IMP), KPC and OXA-48 enzymes and (iii) that many producer isolates were from patients previously
hospitalised in Greece, Turkey and Israel.
This addendum is issued: (i) because the number of referred producers continues to increase sharply (>40 so far in 2009)
In January 2009 we issued a National Resistance Alert concerning carbapenemases in UK Enterobacteriaceae. This followed
consultation with ARHAI and stressed: (i) the growing number of producer isolates referred to the HPA’s Antibiotic Resistance
Monitoring & Reference Laboratory (ARMRL) (8 in all years to 2007; ultimately 21 in 2008); (ii) the diversity of these, variously
with metallo (VIM or IMP), KPC and OXA-48 enzymes and (iii) that many producer isolates were from patients previously
hospitalised in Greece, Turkey and Israel.
This addendum is issued: (i) because the number of referred producers continues to increase sharply (>40 so far in 2009)
and (ii) because a novel enzyme, NDM-1 (New Delhi Metallo
b-Lactamase) is increasingly dominant. NDM-1 is strongly linked
to India and Pakistan and many of the UK cases have recent medical exposure in the Indian-subcontinent. Recognition of risk
patients and prevention of transmission in the UK is critical, since most producers are resistant to ALL reliable antibiotics.