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Nature Scientific Reports. Transmission of Ebola virus from pigs to non-human primates

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  • Nature Scientific Reports. Transmission of Ebola virus from pigs to non-human primates

    Hat-tip Pathfinder

    [Source: Nature Scientific Reports, full text: (LINK). Abstract, edited.]
    Transmission of Ebola virus from pigs to non-human primates

    Hana M. Weingartl,<SUP>1, 2; </SUP>Carissa Embury-Hyatt,<SUP>1; </SUP>Charles Nfon,<SUP>1; </SUP>Anders Leung,<SUP>3; </SUP>Greg Smith<SUP>1; </SUP>& Gary Kobinger<SUP>3, 2</SUP>
    Journal name: Scientific Reports Volume: 2, Article number: 811

    DOI: doi:10.1038/srep00811

    Received 25 April 2012 - Accepted 28 September 2012 - Published 15 November 2012



    Ebola viruses (EBOV) cause often fatal hemorrhagic fever in several species of simian primates including human. While fruit bats are considered natural reservoir, involvement of other species in EBOV transmission is unclear. In 2009, Reston-EBOV was the first EBOV detected in swine with indicated transmission to humans. In-contact transmission of Zaire-EBOV (ZEBOV) between pigs was demonstrated experimentally. Here we show ZEBOV transmission from pigs to cynomolgus macaques without direct contact. Interestingly, transmission between macaques in similar housing conditions was never observed. Piglets inoculated oro-nasally with ZEBOV were transferred to the room housing macaques in an open inaccessible cage system. All macaques became infected. Infectious virus was detected in oro-nasal swabs of piglets, and in blood, swabs, and tissues of macaques. This is the first report of experimental interspecies virus transmission, with the macaques also used as a human surrogate. Our finding may influence prevention and control measures during EBOV outbreaks.





    Affiliations
    1. National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, 1015 Arlington St. Winnipeg, Manitoba, R3E 3M4, Canada
      • Hana M. Weingartl,
      • Carissa Embury-Hyatt,
      • Charles Nfon &
      • Greg Smith
    2. Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
      • Hana M. Weingartl &
      • Gary Kobinger
    3. National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington St., Winnipeg, Manitoba, R3E 3R2, Canada
      • Anders Leung &
      • Gary Kobinger
    Contributions:

    H.M.W. and G.K. conceived the study, design experiments, performed the animal experiments, analyzed and interpreted data, and wrote the manuscript. C.E-H. provided analysis of histopathology and data interpretation; A.L., G.S. and C.N. performed in vitro experiments and analyzed related data.

    Competing financial interests: The authors declare no competing financial interests.

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    Attached Files

  • #2
    Re: Nature Scientific Reports. Transmission of Ebola virus from pigs to non-human primates

    Source: http://www.bbc.co.uk/news/science-environment-20341423


    15 November 2012 Last updated at 19:50 ET

    Growing concerns over 'in the air' transmission of Ebola
    By Matt McGrath Science reporter, BBC World Service

    Canadian scientists have shown that the deadliest form of the ebola virus could be transmitted by air between species.

    In experiments, they demonstrated that the virus was transmitted from pigs to monkeys without any direct contact between them.

    The researchers say they believe that limited airborne transmission might be contributing to the spread of the disease in some parts of Africa.

    They are concerned that pigs might be a natural host for the lethal infection...

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