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Avian influenza H7N9 viruses isolated from humans: What do the gene sequences mean?

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  • Avian influenza H7N9 viruses isolated from humans: What do the gene sequences mean?

    Avian influenza H7N9 viruses isolated from humans: What do the gene sequences mean?

    <ABBR class=published title=2013-04-16>16 April 2013</ABBR>

    There have been over 60 human infections with avian influenza virus H7N9 in China, and cases have been detected outside of Shanghai, including Beijing, Zhejiang, Henan, and Anhui Provinces. Information on the first three cases has now been published, allowing a more detailed consideration of the properties of the viral isolates.

    Analysis of the viral genome sequences reveals that all 8 RNA segments of influenza A/Shanghai/1/2013 virus are phylogenetically distinct from A/Anhui/1/2013 and A/Shanghai/2/2013, suggesting that the virus passed from an animal into humans at least twice. Similar viruses have been isolated from pigeons and chickens, but the source of the human infections is not known. There is as yet no evidence for human to human transmission of the H7N9 viruses, and it seems likely that all of the human infections are zoonotic ? transmission of animal viruses to humans. Since the H7N9 viruses are of low pathogenicity in poultry, infected animals may not display disease symptoms, further facilitating transmission to humans.

    More...
    http://www.virology.ws/2013/04/16/av...(virology+blog)
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  • #2
    Re: Avian influenza H7N9 viruses isolated from humans: What do the gene sequences mean?

    There are currently only 4 publicly released sequences from human H7N9 cases, A/Shanghai/1/2013, A/Shanghai/2/2013, A/Anhui/1/2013, and (A/Hangzhou/1/2013(H7N9)). These are from cases 1,2,3, and 9 respectively in the FluTrackers case list.

    Today Shanghai reported four retrospectively identified H7N9 cases from late March (FT link). They did not identify the specific details of the cases nor did they publicly released the result of the laboratory analyses.

    Until more information is released it is speculation that the confirmations today relate to the offspring of cases #1. (see this thread).


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    Last edited by sharon sanders; April 16, 2013, 10:19 PM. Reason: edit
    http://novel-infectious-diseases.blogspot.com/

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    • #3
      Re: Avian influenza H7N9 viruses isolated from humans: What do the gene sequences mean?

      Emergent H7N9 Human Sequences
      Comprehensive Genetic
      Tracing

      The discussion noted as the topic for this thread restates the points of the initial NEJM Chinese paper including the perplexing mention of a "mutation" at T160A where the wildtype for H7N9 is already Alanine.

      H5N1 Wet Market sub-segment relationships Updated

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