Announcement

Collapse
No announcement yet.

Euro Surveill. Population susceptibility to North American and Eurasian swine influenza viruses in England, at three time points between 2004 and 2011

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Euro Surveill. Population susceptibility to North American and Eurasian swine influenza viruses in England, at three time points between 2004 and 2011

    [Source: Eurosurveillance, full page: (LINK). Abstract, edited.]


    Eurosurveillance, Volume 18, Issue 36, 05 September 2013

    Research articles

    Population susceptibility to North American and Eurasian swine influenza viruses in England, at three time points between 2004 and 2011


    K Hoschler <SUP>1</SUP>, C Thompson<SUP>1</SUP>, I Casas<SUP>2</SUP>, J Ellis<SUP>1</SUP>, M Galiano<SUP>1</SUP>, N Andrews<SUP>3</SUP>, M Zambon<SUP>1</SUP>
    <SUP></SUP>
    <SUP>1</SUP>Public Health England, Microbiology Services Colindale, London, United Kingdom; 2 National Centre for Microbiology, World Health Organization National Influenza Centre, Institute of Health Carlos III, Madrid, Spain; 3 Public Health England, Health Protection Services Colindale, London, United Kingdom
    ________

    Citation style for this article: Hoschler K, Thompson C, Casas I, Ellis J, Galiano M, Andrews N, Zambon M. Population susceptibility to North American and Eurasian swine influenza viruses in England, at three time points between 2004 and 2011. Euro Surveill. 2013;18(36):pii=20578. Available online: http://www.eurosurveillance.org/View...rticleId=20578
    Date of submission: 20 September 2012

    ________

    Age-stratified sera collected in 2004, 2008 and 2010 in England were evaluated for antibody to swine influenza A(H3N2) and A(H1N1) viruses from the United States or Europe as a measure of population susceptibility to the emergence of novel viruses. Children under 11 years of age had little or no measurable antibody to recent swine H3N2 viruses despite their high levels of antibody to recent H3N2 seasonal human strains. Adolescents and young adults (born 1968?1999) had higher antibody levels to swine H3N2 viruses. Antibody levels to swine H3N2 influenza show little correlation with exposure to recent seasonal H3N2 (A/Perth/16/2009) strains, but with antibody to older H3N2 strains represented by A/Wuhan/359/1995. Children had the highest seropositivity to influenza A(H1N1)pdm09 virus, and young adults had the lowest antibody levels to A/Perth/16/2009. No age group showed substantial antibody levels to A/Aragon/RR3218/2008, a European swine H1N1 virus belonging to the Eurasian lineage. After vaccination with contemporary trivalent vaccine we observed evidence of boosted reactivity to swine H3N2 viruses in children and adults, while only a limited boosting effect on antibody levels to A/Aragon/RR3218/2008 was observed in both groups. Overall, our results suggest that different vaccination strategies may be necessary according to age if swine viruses emerge as a significant pandemic threat.


    -
    --------
Working...
X