Announcement

Collapse
No announcement yet.

Rhinovirus genome

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Rhinovirus genome

    3 types of human Rhinovirus (HRV) : A,B,C --> enterovirus --> picornaviridae
    Antwerp Rhinovirus
    bovine


    ~7000 nucleotides , 1 segment




    general genetics about rhinovirus
    ---to be added later---

    how old

    mutation frequency

    recombination

    links


    -----------------------------------
    % nucleotide differences between several viruses: hrvd.gif
    -----------------------------------------
    mutation picture HRVA, genome splitted in 3 parts : hrva.gif
    mutation picture HRVB, genome splitted in 3 parts : hrvb.gif
    mutation picture HRVC, genome splitted in 3 parts : hrvc.gif


    ---------------------------------------------------------------------------
    Human rhinoviruses (HRV) are highly prevalent human respiratory pathogens that belong to the genus Enterovirus. Although recombination within the coding region is frequent in other picornavirus groups, most evidence of recombination in HRV has been restricted to the 5' untranslated region. We analys …

    Although recombination within the coding region is frequent in other picornavirus groups,
    most evidence of recombination in HRV has been restricted to the 5' untranslated region
    HRV-B and HRV-C showed very little evidence of recombination within the coding region
    HRV-A may have been subject to extensive recombination during the period of
    diversification into types.

    Picornaviridae, one of the oldest and most diversified human virus family
    The error rate of picornavirus RNA polymerases has been estimated to range between
    10^−3 and 10^−4 errors/nucleotide/cycle of replication
    ability to rapidly mutate the capsid protein while still conserving replicative fitness

    The total number of minority mutations detected in the four viral populations was 45.
    The number of minority mutations detected in the original inoculum was 32, thus revealing
    that 13 additional minority mutations appeared in the three populations studied
    after 5 days of viral replication.

    --------------------------------------------------------------


    HRV-B and human enteroviruses (HEV) diverged from the last common ancestor
    after their separation from HRV-A.
    In contrast to HEV viruses, HRV-A and HRV-B share also markedly lower GC content
    along the whole genome length.


    (does it walk around the world in yearly waves as does influenza ?)
    (how many years ago did the lineages separate)

    3713 hits for rhinovirus at pubmed
    (72000 for influenza, 11000 for dengue,)
    Attached Files
    I'm interested in expert panflu damage estimates
    my current links: http://bit.ly/hFI7H ILI-charts: http://bit.ly/CcRgT
Working...
X