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Is Arbidol [Russian antiviral] an effective med for this H1N1 flu?
Any Russian doctors able to comment???
From WIKI:
Arbidol
From Wikipedia, the free encyclopedia
Jump to: navigation, search
Arbidol
Systematic (IUPAC) name
1-methyl-2-((phenylthio)methyl)-3-
carbethoxy-4-((dimethylamino)methyl)-5-
hydroxy-6-bromindole hydrochloride
Identifiers
CAS number 131707-23-8
ATC code L03AX
PubChem 131410
DrugBank N/A
Chemical data
Formula C22H28BrClN2O4S
Mol. mass 531.891 g/mol
Pharmacokinetic data
Bioavailability N/A
Metabolism N/A
-
Half life 17–21 hours
Excretion renal
Therapeutic considerations
Pregnancy cat. N/A
Legal status N/A
Routes oral
Arbidol (Russian: Арбидол) (Chinese: 阿比朵尔) is an antiviral treatment for influenza infection used in Russia and China. The drug is manufactured by Moscow-based Masterlek (Russian: Мастерлек). Its acceptance amongst the pharamecutical industry varies, although some Russian studies have shown it to be as effective as other available treatments.
Chemically, Arbidol features an indole core, functionalized at all positions but one with different substituents. The drug inhibits viral entry into target cells, and also stimulates the immune response.
Arbidol is manufactured and made available as both tablets and capsules.
Contents [hide]
1 Status
2 Mode of action
2.1 Biochemistry
2.2 Clinical application
3 Side effects
4 References
5 External links
[edit] Status
Testing of Arbidol's efficacy has mainly occurred in China and Russia,[1][2] and it is well known in these two countries.[3]
The Russian tests showed the drug to be effective as other available treatments,[1] but it has yet to gain universal acceptance amongst the Western pharmaceutical industry. Some regions have welcomed Arbidol as a more affordable and cost-effective option compared with other drugs[citation needed], while others still maintain a level of suspicion over the validity of its safety and efficacy testing.[citation needed] Outbreaks of highly pathogenic avian influenza and the encroaching pandemic threat of H5N1 has seen the drug added to the arsenal of influenza treatments in several countries.[citation needed]
[edit] Mode of action
[edit] Biochemistry
Arbidol inhibits membrane fusion.[4]
Arbidol prevents contact between the virus and target host cells. Fusion between the viral capsid and the cell membrane of the target cell is inhibited. This prevents viral entry to the target cell, and therefore protects it from infection.[5]
Some evidence suggests that the drugs actions are more effective at preventing infections from RNA viruses than infections from DNA viruses.[6]
As well as specific antiviral action against both Influenza A and Influenza B viruses, Arbiodol exhibits modulatory effects on the immune system. The drug stimulates a humoral immune response, induces interferon-production, and stimulates the phagocytic function of macrophages.[7]
[edit] Clinical application
Arbidol is used primarily as an antiviral treatments for influenza. It is compared most with oseltamivir (Tamiflu, Roche).
The drug has also been investigated as a candidate drug for treatment of hepatitis C.[8]
[edit] Side effects
Side effects in children include sensitization to the drug. No known overdose cases have been reported and allergic reactions are limited to people with hypersensitivity.
[edit] References
Any Russian doctors able to comment???
From WIKI:
Arbidol
From Wikipedia, the free encyclopedia
Jump to: navigation, search
Arbidol
Systematic (IUPAC) name
1-methyl-2-((phenylthio)methyl)-3-
carbethoxy-4-((dimethylamino)methyl)-5-
hydroxy-6-bromindole hydrochloride
Identifiers
CAS number 131707-23-8
ATC code L03AX
PubChem 131410
DrugBank N/A
Chemical data
Formula C22H28BrClN2O4S
Mol. mass 531.891 g/mol
Pharmacokinetic data
Bioavailability N/A
Metabolism N/A
-
Half life 17–21 hours
Excretion renal
Therapeutic considerations
Pregnancy cat. N/A
Legal status N/A
Routes oral
Arbidol (Russian: Арбидол) (Chinese: 阿比朵尔) is an antiviral treatment for influenza infection used in Russia and China. The drug is manufactured by Moscow-based Masterlek (Russian: Мастерлек). Its acceptance amongst the pharamecutical industry varies, although some Russian studies have shown it to be as effective as other available treatments.
Chemically, Arbidol features an indole core, functionalized at all positions but one with different substituents. The drug inhibits viral entry into target cells, and also stimulates the immune response.
Arbidol is manufactured and made available as both tablets and capsules.
Contents [hide]
1 Status
2 Mode of action
2.1 Biochemistry
2.2 Clinical application
3 Side effects
4 References
5 External links
[edit] Status
Testing of Arbidol's efficacy has mainly occurred in China and Russia,[1][2] and it is well known in these two countries.[3]
The Russian tests showed the drug to be effective as other available treatments,[1] but it has yet to gain universal acceptance amongst the Western pharmaceutical industry. Some regions have welcomed Arbidol as a more affordable and cost-effective option compared with other drugs[citation needed], while others still maintain a level of suspicion over the validity of its safety and efficacy testing.[citation needed] Outbreaks of highly pathogenic avian influenza and the encroaching pandemic threat of H5N1 has seen the drug added to the arsenal of influenza treatments in several countries.[citation needed]
[edit] Mode of action
[edit] Biochemistry
Arbidol inhibits membrane fusion.[4]
Arbidol prevents contact between the virus and target host cells. Fusion between the viral capsid and the cell membrane of the target cell is inhibited. This prevents viral entry to the target cell, and therefore protects it from infection.[5]
Some evidence suggests that the drugs actions are more effective at preventing infections from RNA viruses than infections from DNA viruses.[6]
As well as specific antiviral action against both Influenza A and Influenza B viruses, Arbiodol exhibits modulatory effects on the immune system. The drug stimulates a humoral immune response, induces interferon-production, and stimulates the phagocytic function of macrophages.[7]
[edit] Clinical application
Arbidol is used primarily as an antiviral treatments for influenza. It is compared most with oseltamivir (Tamiflu, Roche).
The drug has also been investigated as a candidate drug for treatment of hepatitis C.[8]
[edit] Side effects
Side effects in children include sensitization to the drug. No known overdose cases have been reported and allergic reactions are limited to people with hypersensitivity.
[edit] References
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