Denmark - Dane with novel H1N1 found resistant to Tamiflu

[Aruna]

Originally Posted by tropical

"The infected Dane had been in close contact with another infected person, and was therefore prevented treatment with Tamiflu."


What is the meaning of this, why it is important to wrote "with another infected person" - does it mean that this "infected person" have a new flu form already known to be tamiflu resistant and because of this they start an Relenza-only treatment?

If not, why they start an Relenza-only treatment on an patient previously supposedly non treated with Tamiflu, did they miss the first 2 days (which somewhere stated to be best also for Relenza(?)),
or what?

Any more details?

He was in close contact with another person who had been sick and was put on tamiflu before he had any symptoms as a preventive messure, when he got sick and tested positive for h1n1 despite the tamiflu treatment he was given relenza. (Here in Scandinavia they still put everyone in contact with a positive case on tamiflu)

[Dutchy]

Roche says 1st case of H1N1 resistance to Tamiflu

29 Jun 2009 14:54:14 GMT

Source: Reuters

ZURICH, June 29 (Reuters) - A patient with H1N1 influenza in Denmark showed resistance to Roche Holding AG's antiviral Tamiflu, a company executive said on Monday.

"This is the first case we have of it in H1N1," David Reddy, Roche's pandemic taskforce leader, told reporters on a conference call.

http://www.alertnet.org/thenews/newsdesk/WEA8792.htm

[Dutchy]

UPDATE 1-Roche finds 1st case of H1N1 resistance to Tamiflu

Mon Jun 29, 2009
.
(Adds details)

ZURICH, June 29 (Reuters) - A patient with H1N1 influenza in Denmark showed resistance to Roche Holding AG's (ROG.VX) Tamiflu, the main antiviral flu drug, a company executive said on Monday.

"While receiving the drug, the patient appeared to develop resistance to it," David Reddy, Roche's pandemic taskforce leader, told reporters on a conference call on the Danish case. "This is the first report we have of it in H1N1."

The World Health Organisation has raised its pandemic flu alert on the H1N1 flu virus to phase 6 on a six-point scale, indicating the first influenza pandemic since 1968 is under way.

Common seasonal flu can resist Tamiflu and Reddy said a case of resistance in H1N1 was not unexpected, adding Roche has been working on strategies to counter such a development.

http://www.reuters.com/article/marke...21784420090629

[HenryN]

Commentary

[Dutchy]

Roche Executive: Tamiflu Is Still Working In Swine Flu

ZURICH -(Dow Jones)- Roche Holding AG (ROG.VX) Monday said that its drug Tamiflu still works in the currently spreading swine flu virus, and that a patient in Denmark who had developed resistance to the drug had done so during treatment.

"Such a development had to be expected, and is no surprise from a scientific point of view," David Reddy, Roche's Pandemic Taskforce leader told journalists on a conference call.

This is a case of so-called drug-induced resistance, which is rare, but it was known from clinical studies that this can happen, Reddy said. Drug-induced resistance occurs when a patient who is taking the drug develops resistance. It differs from naturally incurring resistance, where a virus strain in itself isn't responding to the drug.

This isn't the case here, meaning that Tamiflu is still working against swine flu, and Roche thus expects the World Health Organisation to continue to back the use of the drug, Reddy said.

http://english.capital.gr/news.asp?id=765631

[Dutchy]

UNE 29, 2009, 11:31 A.M. ET

Roche's Tamiflu Still Works In Swine Flu Despite Denmark Case


By Anita Greil

Of DOW JONES NEWSWIRES

ZURICH (Dow Jones)--Roche Holding AG (ROG.VX) said Monday that a patient in Denmark developed resistance to Tamiflu, but that the drug is still effective in the circulating H1N1 swine flu virus.

"Such a development had to be expected, and is no surprise from a scientific point of view," David Reddy, Roche's Pandemic Taskforce leader told journalists on a conference call.

The Danish patient, who has since recovered, was taking the drug as a prevention to avoid the contraction of swine flu, Reddy said. He was probably already infected with the virus, and resistance to the drug emerged because he was given the lower prevention dose.

This is a case of so-called drug-induced resistance, which is rare, but it was known from clinical studies that this can happen, Reddy said. Around 0.4% of adults, and around 4% of children, were shown to develop resistance to Tamiflu in clinical studies, he said.

Drug-induced resistance occurs when a patient who is taking the drug develops resistance. It differs from naturally incurring resistance, where a virus strain in itself isn't responding to the drug. This had been the case with the winter flu virus that was spreading in Europe in 2008, he added.

This isn't the case here, meaning that Tamiflu is still working against swine flu, and Roche thus expects the World Health Organization to continue to back the use of the drug, Reddy said.

At some point, there will certainly be resistance to Tamiflu, said Birgit Kulhoff, pharmaceutical analyst in Zurich with private bank Rahn & Bodmer.

"Sooner or later there will be resistance, and I would expect that to happen when the swine flu virus starts mixing with seasonal flu viruses," she said.

As such, an isolated case in Denmark doesn't yet change the sales prospects of Tamiflu. "It would have been much more worrisome if we saw repeated cases of resistance in the Southern hemisphere, where it's winter now, and the viruses could mix," she said.

http://online.wsj.com/article/BT-CO-...29-709515.html

[theforeigner]

My translation of the black highlighted part of the newsreport:

The person was originally not ill at all. The person was in precaution treatment with Tamiflu, because the person had been in close contact with a person who was infected with Swine Flu abroad (OR the person had been abroad and been in close contact with a H1N1 infected person, can´t be sure which it is). After 5 days treatment with Tamiflu, the person suddenly got sick with H1N1, but it didn´t seem like the treatment had any effect. It turned out via tests her in Denmark and in UK, that the person had developed resistance twards Tamiflu, explains Nils Strandberg ( President & CEO of -Statens Serum Institut )
Insted the person was treated with Relenza. - We can be glad that the person today is well and have not infected others said Nils Strandberg.

The Journalist ask Nils Strandberg:
But isen´t it a worrying perspectives that Tamiflu now no longer can be concidered a safe tratment against Swine Flu?

-Yes it is worrying if Tamiflu does not work on the most vulnerable groups. But there are still things that work if a vulnerable patient get infected with H1n1. There is another treatment Relenza.




http://ekstrabladet.dk/kup/sundhed/article1188161.ece

Dansker er resistent overfor Tamiflu



En dansker er som den første i verden blevet resistent overfor medicin mod svineinfluenza H1N1. Dystre perspektiver for risiko-patienter

16:40 - 29. jun. 2009 | Frederik Bjerre Andersen, Gitte Hejberg


Statens Serum Institut har fundet den første person i verden, der er resistent overfor medicinen oseltamivir, der sælges under navnet Tamiflu og blandt andet har vist sig virksom mod svineinfluenzaen H1N1.

Det er det første tilfælde af resistens overfor medicinen på verdensplan. Det er forventeligt, at influenzavirus kan mutere spontant. Resistensen har ikke ændret H1N1-virus’ evne til at smitte eller fremkalde sygdom, meddeler instuttet.

- Både bakterier og vira kan mutere og blive resistente. Og det er altså det, der er sket her, bekræfter administrerende direktør på Statens Serums Institut Nils Strandberg.

- Vedkommende var til at begynde med slet ikke syg. Den pågældende var i forebyggende behandling med Tamiflu, fordi vedkommende havde været i tæt kontakt med en svineinfluenza-ramt i udlandet. Da der var gået fem dage med Tamiflu, blev personen så pludselig syg med H1N1, men det så ikke ud til, at medicinen virkede. Det viste sig så via prøver her og i England, at personen var blevet resistens, fortæller Nils Strandberg.

Uheldigt for alvorligt syge
I stedet blev patienten behandlet med medicinen Relenza.

- Vi kan glæde os over, at personen i dag er helt rask og ikke har smittet andre, siger Nils Standberg.

- Men der er vel dystre perspektiver i, at Tamiflu nu ikke længere kan betragtes som et sikkert middel mod svineinfluenza?

- Ja, det er bekymrende, hvis Tamiflu ikke virker på de mest udsatte grupper. Men der er stadig noget at gøre, hvis en svagelig patient bliver smittet med H1N1. Der er jo et andet stof, som man kan bruge.
Skruer ned for forebyggende brug
Ifølge Nils Strandberg vil fundet af den resistente dansker betyde, at lægerne fremover vil blive mere tilbageholdende med at bruge Tamiflu forebyggende - med mindre der altså ligefrem er tale om meget syge og skrøbelige patienter.

- Hvorfor er det netop en dansker, der bliver den første resistente influenza-patient?

- Det beror nok mest på et tilfælde. Vi har et godt system, hvor vi er gode til at overvåge situationen.

Episoden slår fast, at influenza-virus kan mutere, og at Tamiflu på ingen måde kan betragtes som mirakelmedicin. Tamiflu kan i forvejen ikke kurere influenza, men medicinen kan nedsætte symptomerne og forkorte forløbet.

Epidemi til efteråret
Selv om sommeren, udendørslivet og de lukkede skoler er ensbetydende med mindre influenzasmitte i Danmark, vil danskernes rejseaktivitet sommeren over betyde, at der bliver slæbt mere smitte til landet.

- Vi skal formodentlig frem til det sene efterår eller vinter, før vi kan risikere en H1N1-epidemi herhjemme. Men det behøver ikke at give problemer, da det stadig er en ret mild influenzatype, siger Nils Standberg.

[Dutchy]

Mon, 16:16 29 Jun 2009 GMT

Denmark finds 1st case of H1N1 resistance to Tamiflu

29 Jun 2009 16:10:11 GMT

Source: Reuters

* Patient showed resistance to main antiviral flu drug

* Drug maker says resistance not unexpected

(Rewrites with Danish comment, adds details and background)

By Sam Cage and Teis Jensen

ZURICH/COPENHAGEN, June 29 (Reuters) - Scientists have established the first case of the new H1N1 influenza strain showing resistance to Tamiflu, the main antiviral flu drug, Danish officials and the manufacturer said on Monday.

"While receiving the drug, the patient appeared to develop resistance to it," David Reddy, Roche Holding AG's pandemic taskforce leader, told reporters on a conference call on a case observed in Denmark. "This is the first report we have of it in H1N1."

Common seasonal flu can resist Tamiflu and Reddy said a case of resistance in H1N1 -- also know as swine flu -- was not unexpected. Roche had been working on strategies to counter such a development.

The World Health Organization declared an influenza pandemic earlier this month and advised governments to prepare for a long-term battle against an unstoppable new flu virus. The WHO had no immediate comment on the case of Tamiflu resistance.

The United Nations agency raised its pandemic flu alert to phase 6 on a six-point scale, indicating the first influenza pandemic since 1968 is under way. [ID:nLC321991]

"The person is well now and no further contagion with the resistent virus has been detected," Denmark's State Serum Institute said in a statement.

Roche shares closed up 1.4 percent at 149 Swiss francs, outperforming a 0.7 percent firmer DJ Stoxx European drugs index <.SXDP>.

This case does not change the recommendation to use Tamiflu, the institute said.

The U.S. Centers for Disease Control and Prevention has expressed concern the new strain may mix with seasonal flu strains, which are still circulating.

The WHO has said Tamiflu was working against strains of the new H1N1 flu but some analysts have expressed concern it might be less effective than Relenza, GlaxoSmithKline's inhaled drug, since there have been widespread reports of resistance by seasonal H1N1 flu.

The seasonal strain of H1N1 is a distant cousin of the swine flu and was widely resistant to Tamiflu this year. (Additional reporting by Paul Arnold; Editing by David Holmes)

http://www.alertnet.org/thenews/newsdesk/LT265113.htm

[HenryN]

The two key qualifiers in the comments from Roche are "appeared" and "probably", indicating they have ZERO evidence that the patient was NOT infected with pandemic H1N1 with the "mutation" PRIOR to prophylactic treatment.

[St Michael]

Originally Posted by theforeigner

After 5 days treatment with Tamiflu, the person suddenly got sick with H1N1, but it didn´t seem like the treatment had any effect. It turned out via tests her in Denmark and in UK, that the person had developed resistance twards Tamiflu, explains Nils Strandberg ( President & CEO of -Statens Serum Institut )
Insted the person was treated with Relenza. - We can be glad that the person today is well and have not infected others said Nils Strandberg.

And how do we know they have not infected others? Were they quarantined?

And what are the odds of this resistance spontaneously arising elsewhere, even if this particular resistant virus was not communicated to others?

[HenryN]

Originally Posted by Dutchy

"While receiving the drug, the patient appeared to develop resistance to it," David Reddy, Roche's pandemic taskforce leader, told reporters on a conference call on the Danish case. "This is the first report we have of it in H1N1."


http://www.reuters.com/article/marke...21784420090629

Qualifier #1.

[HenryN]

Originally Posted by Dutchy

UNE 29, 2009, 11:31 A.M. ET


The Danish patient, who has since recovered, was taking the drug as a prevention to avoid the contraction of swine flu, Reddy said. He was probably already infected with the virus, and resistance to the drug emerged because he was given the lower prevention dose.



http://online.wsj.com/article/BT-CO-...29-709515.html

Qualifier #2

[Dutchy]

Originally Posted by niman

The two key qualifiers in the comments from Roche are "appeared" and "probably", indicating they have ZERO evidence that the patient was NOT infected with pandemic H1N1 with the "mutation" PRIOR to prophylactic treatment.

Yes, Roche is not an independent source.

[HenryN]

Originally Posted by St Michael

And how do we know they have not infected others? Were they quarantined?

And what are the odds of this resistance spontaneously arising elsewhere, even if this particular resistant virus was not communicated to others?

Roche has ZERO evidence that the resistance (probably H274Y) was not present PRIOR to prophylactic treatment. This is ALL hopes and dreams on their part.

For their dreams to come true, they have to show the patient had wild type prior to treatment or the patient who infected the patient had wild type.

Since they have NEITHER, they say what PROBABLY or APPEARED to have happen.

[HenryN]

Originally Posted by Dutchy

Yes, Roche is not an independent source.

Actually, they are VERY dependent on tamiflu, so if they had EVIDENCE of wild type in the patient or the patient who infected the patient they would have said so.

Instead they said what PROBABLY or APPEARED to happen.

Their press release is VERY weak and the between the lines read is OBVIOUS (no evidence for their hopes and dreams).

[sharon sanders]

Originally Posted by theforeigner

My translation of the black highlighted part of the newsreport:

The person was originally not ill at all. The person was in precaution treatment with Tamiflu, because the person had been in close contact with a person who was infected with Swine Flu abroad (OR the person had been abroad and been in close contact with a H1N1 infected person, can´t be sure which it is). After 5 days treatment with Tamiflu, the person suddenly got sick with H1N1, but it didn´t seem like the treatment had any effect. It turned out via tests her in Denmark and in UK, that the person had developed resistance twards Tamiflu, explains Nils Strandberg ( President & CEO of -Statens Serum Institut )
Insted the person was treated with Relenza. - We can be glad that the person today is well and have not infected others said Nils Strandberg.

The Journalist ask Nils Strandberg:
But isen´t it a worrying perspectives that Tamiflu now no longer can be concidered a safe tratment against Swine Flu?

-Yes it is worrying if Tamiflu does not work on the most vulnerable groups. But there are still things that work if a vulnerable patient get infected with H1n1. There is another treatment Relenza.




http://ekstrabladet.dk/kup/sundhed/article1188161.ece

Dansker er resistent overfor Tamiflu



En dansker er som den første i verden blevet resistent overfor medicin mod svineinfluenza H1N1. Dystre perspektiver for risiko-patienter

16:40 - 29. jun. 2009 | Frederik Bjerre Andersen, Gitte Hejberg


Statens Serum Institut har fundet den første person i verden, der er resistent overfor medicinen oseltamivir, der sælges under navnet Tamiflu og blandt andet har vist sig virksom mod svineinfluenzaen H1N1.

Det er det første tilfælde af resistens overfor medicinen på verdensplan. Det er forventeligt, at influenzavirus kan mutere spontant. Resistensen har ikke ændret H1N1-virus’ evne til at smitte eller fremkalde sygdom, meddeler instuttet.

- Både bakterier og vira kan mutere og blive resistente. Og det er altså det, der er sket her, bekræfter administrerende direktør på Statens Serums Institut Nils Strandberg.

- Vedkommende var til at begynde med slet ikke syg. Den pågældende var i forebyggende behandling med Tamiflu, fordi vedkommende havde været i tæt kontakt med en svineinfluenza-ramt i udlandet. Da der var gået fem dage med Tamiflu, blev personen så pludselig syg med H1N1, men det så ikke ud til, at medicinen virkede. Det viste sig så via prøver her og i England, at personen var blevet resistens, fortæller Nils Strandberg.

Uheldigt for alvorligt syge
I stedet blev patienten behandlet med medicinen Relenza.

- Vi kan glæde os over, at personen i dag er helt rask og ikke har smittet andre, siger Nils Standberg.

- Men der er vel dystre perspektiver i, at Tamiflu nu ikke længere kan betragtes som et sikkert middel mod svineinfluenza?

- Ja, det er bekymrende, hvis Tamiflu ikke virker på de mest udsatte grupper. Men der er stadig noget at gøre, hvis en svagelig patient bliver smittet med H1N1. Der er jo et andet stof, som man kan bruge.
Skruer ned for forebyggende brug
Ifølge Nils Strandberg vil fundet af den resistente dansker betyde, at lægerne fremover vil blive mere tilbageholdende med at bruge Tamiflu forebyggende - med mindre der altså ligefrem er tale om meget syge og skrøbelige patienter.

- Hvorfor er det netop en dansker, der bliver den første resistente influenza-patient?

- Det beror nok mest på et tilfælde. Vi har et godt system, hvor vi er gode til at overvåge situationen.

Episoden slår fast, at influenza-virus kan mutere, og at Tamiflu på ingen måde kan betragtes som mirakelmedicin. Tamiflu kan i forvejen ikke kurere influenza, men medicinen kan nedsætte symptomerne og forkorte forløbet.

Epidemi til efteråret
Selv om sommeren, udendørslivet og de lukkede skoler er ensbetydende med mindre influenzasmitte i Danmark, vil danskernes rejseaktivitet sommeren over betyde, at der bliver slæbt mere smitte til landet.

- Vi skal formodentlig frem til det sene efterår eller vinter, før vi kan risikere en H1N1-epidemi herhjemme. Men det behøver ikke at give problemer, da det stadig er en ret mild influenzatype, siger Nils Standberg.

Thank you very much theforeigner!

[HenryN]

Roche Sees First Case of Tamiflu-Resistant Swine Flu (Update1)


Share | Email | Print | A A A



By Christian Wienberg and Marthe Fourcade
June 29 (Bloomberg) -- Roche Holding AG said a swine flu patient treated with its Tamiflu drug in Denmark showed resistance to the antiviral medicine for the first time.
The patient was given a low dose of Tamiflu preventively after coming in contact with someone infected with the H1N1 pandemic virus, said David Reddy, who heads Roche’s influenza task force. The person developed flu symptoms and was found to have a virus mutation that evaded the drug, Reddy said on a conference call today.
The patient has recovered and doctors have found no other people carrying the resistant strain, Denmark’s National Board of Health said today in a statement on its Web site. Tamiflu studies show that 0.4 percent of adults and 4 percent of children with seasonal influenza develop resistance, according to Reddy.
“We know from seasonal flu that a proportion of patients can develop resistance,” Reddy said. “We fully expect that this also can occur during treatment with a new flu strain.”
The new virus, which has killed more than 300 people worldwide, “remains sensitive to the drug,” Reddy said. “What this does underscore is the continued need for resistance monitoring.”
Gauging Resistance
The virus hasn’t acquired new characteristics that make it resistant to Tamiflu, according to Reddy. Instead, in this one patient, when faced with a low dose of the medicine it found a way to evade it, he said. That’s known as drug-induced resistance, he said.
Roche, based in Basel, Switzerland, is studying flu sufferers in several countries to gauge drug resistance.
Swine flu hasn’t previously shown resistance to Roche’s Tamiflu or GlaxoSmithKline Plc’s Relenza, antiviral medicines that reduce the severity of the disease when administered in the first few days. The World Health Organization reported today that there have been 70,893 cases of the virus globally, including 44 people in Denmark.
“This one case of a resistant virus doesn’t change our recommendations to use Tamiflu and the treatment remains part of Denmark’s preparedness measures,” the National Board of Health said in the statement.
To contact the reporter on this story: Christian Wienberg in Copenhagen at cwienberg@bloomberg.net; Marthe Fourcade in Paris at mfourcade@bloomberg.net
Last Updated: June 29, 2009 11:52 EDT

http://www.bloomberg.com/apps/news?p...d=an3udfKwF4Do

[gsgs]

> The patient has recovered

so, when was it ? What delay can we expect in similar potential
future official statements ?

[HenryN]

Originally Posted by gsgs

> The patient has recovered

so, when was it ? What delay can we expect in similar potential
future official statements ?

I did not see a press release at the Roche website. They held a conference call, and the media reports (with PROBABLY and APPEARS) presumably came from the conference call.

I suspect Roche would like to talk about this as little as possible, because as soon as they are asked about sequences of thed virus prior to treatment or the virus from the person who infected the patient with resistant H1N1, they will be force to admit there comments are based on NO data (just hopes and dreams about reporters failing to ask to correct question).

[sharon sanders]

And....what are the chances that this is the only person in the world that has not responded to Tamiflu for the treatment of Swine flu? It is the first recorded case - that is all.

I think people who follow FT knew that oseltamivir treatment might become ineffective. So this is no surprise.

We urge quick sequence release so that the world's scientists can study this event.

[St Michael]

Originally Posted by niman

doctors have found no other people carrying the resistant strain, Denmark’s National Board of Health said today
...

The virus hasn’t acquired new characteristics that make it resistant to Tamiflu, according to Reddy. Instead, in this one patient, when faced with a low dose of the medicine it found a way to evade it, he said. That’s known as drug-induced resistance, he said.

...

“This one case of a resistant virus doesn’t change our recommendations to use Tamiflu and the treatment remains part of Denmark’s preparedness measures,” the National Board of Health said in the statement.

Yes...and the victim was probably a twelve year old obese pregnant male, too.

[HenryN]

Originally Posted by Florida1

And....what are the chances that this is the only person in the world that has not responded to Tamiflu for the treatment of Swine flu? It is the first recorded case - that is all.

I think people who follow FT knew that oseltamivir treatment might become ineffective. So this is no surprise.

We urge quick sequence release so that the world's scientists can study this event.

The sequence after teatment won't say much. It is the sequence PRIOR to treatment (from the tested patient or the patient who infected the tested patient) and I suspect NEITHER exists (because they would have been mentioned in the comments).

[tropical]

"the lower prevention dose"

prevention dose: 1 x daily 75mg (or new ...mg)
treatment dose: 2 x daily 75mg (or new ...mg)


So if the dosage could be a factor instead of an resistant mutation of the virus - "hopes and dreams" - at least until it became throughout unusable -

"Instead, in this one patient, when faced with a low dose of the medicine it found a way to evade it, he said. That’s known as drug-induced resistance, he said."

- so (by continuing to dream) to cope with this chimera virus if the above realy are linked to dosage only, Roche need a change in a preventive dosage policy:
prevention dose=treatment dose

If the dreams proved to be only dreams, the scientifical health shielding will be another "blow".

[HenryN]

Originally Posted by tropical

"the lower prevention dose"

prevention dose: 1 x daily 75mg (or new ...mg)
treatment dose: 2 x daily 75mg (or new ...mg)


So if the dosage could be a factor instead of an resistant mutation of the virus - "hopes and dreams" - at least until it became throughout unusable -

"Instead, in this one patient, when faced with a low dose of the medicine it found a way to evade it, he said. That’s known as drug-induced resistance, he said."

- so (by continuing to dream) to cope with this chimera virus if the above realy are linked to dosage only, Roche need a change in a preventive dosage policy:
prevention dose=treatment dose

If the dreams proved to be only dreams, the scientifical health shielding will be another "blow".

Resistance can develop by using a sub-optimal dose, as happened with H5N1 in Vietnam. However, it that case the sister's brother (who infected her) did NOT have the resistance (H274Y or S294N) so there was evidence that the resistance developed in response to treatment (the H5N1 isoaltes from the sister had BOTH).

For pandemic H1N1 in Denmark, NO ONE has provided ANY such evidence (because it doesn't exist).

Roche (and WHO) are relying on NEGATIVE evidence (no one has reported the resistance previously and most have concentrated on airport screening involving a VERY small number of patients. They need to rapidly screen COMMUNITY SPREAD of the H274Y spreading silently (remember - almost no one with mild H1N1 is being treated in the community).

[HenryN]

(Adds background)
ZURICH (Dow Jones)--Roche Holding AG (ROG.VX) said Monday that a patient in Denmark developed resistance to Tamiflu, but that the drug is still effective in the circulating H1N1 swine flu virus, which is causing the first flu pandemic of the 21st century.
"Such a development had to be expected, and is no surprise from a scientific point of view," David Reddy, Roche's Pandemic Taskforce leader told journalists on a conference call.
The Danish patient, who has since recovered, was taking the drug as a prevention to avoid the contraction of swine flu, Reddy said. He was probably already ...

http://online.wsj.com/article/BT-CO-...29-710385.html

[HenryN]

Originally Posted by niman

(Adds background)
ZURICH (Dow Jones)--Roche Holding AG (ROG.VX) said Monday that a patient in Denmark developed resistance to Tamiflu, but that the drug is still effective in the circulating H1N1 swine flu virus, which is causing the first flu pandemic of the 21st century.
"Such a development had to be expected, and is no surprise from a scientific point of view," David Reddy, Roche's Pandemic Taskforce leader told journalists on a conference call.
The Danish patient, who has since recovered, was taking the drug as a prevention to avoid the contraction of swine flu, Reddy said. He was probably already ...

http://online.wsj.com/article/BT-CO-...29-710385.html

Note that the above teaser from the WSJ includes the REQUIRED "probably".

[tropical]

#56:
"They need to rapidly screen COMMUNITY SPREAD of the H274Y spreading silently (remember - almost no one with mild H1N1 is being treated in the community)."


I agree Dr. Niman,
but seems that such measures will not be seen, worldwide.

The false negative fast tests problem, and the actual policies, seems to suggest an overall failure to: initialy insurgence containment; further screen/test inner containment; and failured treatments when moderate/serious.

Did remain something the humans could made successfuly in time,
or we will seen only after-battle (pandemic) scientific explanations of the illness, without any modern treatment?

The New Era of Middle Age ...

[Dutchy]

From ECDC Europe, today's update:

Denmark health authorities have reported today one case of oseltamivir-resistant A(H1N1)v influenza virus (29. juni 2009 - Resistens hos pandemisk influenza A H1N1v påvist i Danmark).

This is an isolated case, part of a cluster of cases investigated.

No additional cases have been identified through extensive contact tracing.

http://ecdc.europa.eu/en/files/pdf/H...29_1700hrs.pdf

[theforeigner]

I just viewed Denmarks two main TV-channels DR and TV2´s primetime newsreports (1/2 houer each) and not one word about the new danish tamiflu resistance case !

A cupple of houers ago, I called the The National Board of Health press chief Mette Ebdrup and asked her if she could arrange that in depth information about the danish Tamiflu resitance case could be posted on their webpage in english, and/or if she could arrange that a H1N1 representative from The National Board of Health or Statens Serum Institut could attend Flutrackers so that more precice information could be provided.
Her answer was that she was very buissy so she didn´t have time to talk and that all info was provided to WHO and they would provide relevant information.
I asked if she knew when WHO would release this info but she said she didn´t know.

Weeks ago I provided both The National Board of Health and Statens Serum Institut (+ different newsmedia) links to Flutrackers and encuraged them to read/become members, wheter any of them read or have become members I dont know.

Media reports, meaning LACK OF media reports, on H1N1 in Denmark and elsewere, IMO is a HUGE problem her in Denmark.

One of many consequense is that lots of people her in Denmark who get flu symptoms will possibly not contact a doctor unless they get seriously ill, therefore we possibly don´t know if feks. the Tamiflu resistance patient infected others.

[HenryN]

Originally Posted by Dutchy

From ECDC Europe, today's update:

Denmark health authorities have reported today one case of oseltamivir-resistant A(H1N1)v influenza virus (29. juni 2009 - Resistens hos pandemisk influenza A H1N1v påvist i Danmark).

This is an isolated case, part of a cluster of cases investigated.

No additional cases have been identified through extensive contact tracing.

http://ecdc.europa.eu/en/files/pdf/H...29_1700hrs.pdf

How many in the "cluster" were H1N1 positive?????? (hint: if you guessed "1", you are too high).