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July 21st, 2009, 05:11 PM
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Yamaguchi Japan Tamiflu Resistant Sequence Released
The sequence of a second example of H274Y in Japan has been released'
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July 21st, 2009, 05:11 PM
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Re: Yamaguchi Japan Tamiflu Resistant Sequence Released
LOCUS GQ397279 1410 bp cRNA linear VRL 21-JUL-2009
DEFINITION Influenza A virus (A/Yamaguchi/22/2009(H1N1)) segment 6
neuraminidase (NA) gene, complete cds.
ACCESSION GQ397279
VERSION GQ397279.1 GI:254548843
DBLINK Project: 37813
KEYWORDS .
SOURCE Influenza A virus (A/Yamaguchi/22/2009(H1N1))
ORGANISM Influenza A virus (A/Yamaguchi/22/2009(H1N1))
Viruses; ssRNA negative-strand viruses; Orthomyxoviridae;
Influenzavirus A.
REFERENCE 1 (bases 1 to 1410)
AUTHORS Ujike,M., Obuchi,M., Tashiro,M., Horikawa,H., Kato,Y., Oguchi,A.,
Fujita,N. and Odagiri,T.
TITLE Human infection with novel swine H1N1 influenza
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 1410)
AUTHORS Toda,S. and Sirabe,S.
TITLE Direct Submission
JOURNAL Submitted (21-JUL-2009) Yamaguchi Prefectural Institute of Public
Health and Environment, Yamagauchi, Japan
REFERENCE 3 (bases 1 to 1410)
AUTHORS Ujike,M., Obuchi,M., Tashiro,M. and Odagiri,T.
TITLE Direct Submission
JOURNAL Submitted (21-JUL-2009) National Institute of Infectious Diseases,
4-7-1, Gakuen, Musashi-murayama, Tokyo 208-0011, Japan
COMMENT Swine influenza A (H1N1) virus isolated during human swine flu
outbreak of 2009.
FEATURES Location/Qualifiers
source 1..1410
/organism="Influenza A virus (A/Yamaguchi/22/2009(H1N1))"
/mol_type="viral cRNA"
/strain="A/Yamaguchi/22/2009"
/serotype="H1N1"
/host="Homo sapiens"
/db_xref="taxon: 660652"
/segment="6"
/country="Japan"
/collection_date="2009"
/note="lineage: swl; passage history: MDCK2; resistance to
oseltamivir"
gene 1..1410
/gene="NA"
CDS 1..1410
/gene="NA"
/codon_start=1
/product="neuraminidase"
/protein_id=" ACT67256.1"
/db_xref="GI:254548844"
/translation="MNPNQKIITIGSVCMTIGMANLILQIGNIISIWISHSIQLGNQN
QIETCNQSVITYENNTWVNQTYVNISNTNFAAGQSVVSVKLAGNSSLCPV SGWAIYSK
DNSIRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDR SPYRTLMS
CPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDNGAVAVLKYNG IITDTIKS
WRNNILRTQESECACVNGSCFTVMTDGPSDGQASYKIFRIEKGKIVKSVE MNAPNYYY
EECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNP RPNDKTGS
CGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTD NNFSIKQD
IVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSS ISFCGVNS
DTVGWSWPDGAELPFTIDK"
ORIGIN
1 atgaatccaa accaaaagat aataaccatt ggttcggtct gtatgacaat tggaatggct
61 aacttaatat tacaaattgg aaacataatc tcaatatgga ttagccactc aattcaactt
121 gggaatcaaa atcagattga aacatgcaat caaagcgtca ttacttatga aaacaacact
181 tgggtaaatc agacatatgt taacatcagc aacaccaact ttgctgctgg acagtcagtg
241 gtttccgtga aattagcggg caattcctct ctctgccctg ttagtggatg ggctatatac
301 agtaaagaca acagtataag aatcggttcc aagggggatg tgtttgtcat aagggaacca
361 ttcatatcat gctccccctt ggaatgcaga accttcttct tgactcaagg ggccttgcta
421 aatgacaaac attccaatgg aaccattaaa gacaggagcc catatcgaac cctaatgagc
481 tgtcctattg gtgaagttcc ctctccatac aactcaagat ttgagtcagt cgcttggtca
541 gcaagtgctt gtcatgatgg catcaattgg ctaacaattg gaatttctgg cccagacaat
601 ggggcagtgg ctgtgttaaa gtacaacggc ataataacag acactatcaa gagttggaga
661 aacaatatat tgagaacaca agagtctgaa tgtgcatgtg taaatggttc ttgctttact
721 gtaatgaccg atggaccaag tgatggacag gcctcataca aaatcttcag aatagaaaag
781 ggaaagatag tcaaatcagt cgaaatgaat gcccctaatt attactatga ggaatgctcc
841 tgttatcctg attctagtga aatcacatgt gtgtgcaggg ataactggca tggctcgaat
901 cgaccgtggg tgtctttcaa ccagaatctg gaatatcaga taggatacat atgcagtggg
961 attttcggag acaatccacg ccctaatgat aagacaggca gttgtggtcc agtatcgtct
1021 aatggagcaa atggagtaaa aggattttca ttcaaatacg gcaatggtgt ttggataggg
1081 agaactaaaa gcattagttc aagaaacggt tttgagatga tttgggatcc gaacggatgg
1141 actgggacag acaataactt ctcaataaag caagatatcg taggaataaa tgagtggtca
1201 ggatatagcg ggagttttgt tcagcatcca gaactaacag ggctggattg tataagacct
1261 tgcttctggg ttgaactaat cagagggcga cccaaagaga acacaatctg gactagcggg
1321 agcagcatat ccttttgtgg tgtaaacagt gacactgtgg gttggtcttg gccagacggt
1381 gctgagttgc catttaccat tgacaagtaa
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July 21st, 2009, 05:14 PM
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Senior User
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Re: Yamaguchi Japan Tamiflu Resistant Sequence Released
So does this, coupled with the quebec resistance, indicate that there is a circulating strain with H274Y?
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July 21st, 2009, 05:20 PM
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Re: Yamaguchi Japan Tamiflu Resistant Sequence Released
Quote:
Originally Posted by Rwilmer
So does this, coupled with the quebec resistance, indicate that there is a circulating strain with H274Y?
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The circumstances surrounding this sequence are unclear. The Quebec sequence appears to be from a contact taking a prophylactic dose of Tamiflu. This sequence has H274Y and it is assumed that the Quebec sequence also has H274Y, but on a different genetic background.
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July 21st, 2009, 05:21 PM
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Posts: 781
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Re: Yamaguchi Japan Tamiflu Resistant Sequence Released
Quote:
Originally Posted by Rwilmer
So does this, coupled with the quebec resistance, indicate that there is a circulating strain with H274Y?
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The Quebec case seems to imply infection from a family member. We would need at least a sequence from the family member who may have been the source of the older man's infection. But there is the question being raised in that thread: did the man with the known resistant strain spread it?
__________________
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I am not a doctor, virologist, biologist, etc. I am a layman with a background in the physical sciences.
Attempting to blog an nascent pandemic: Diary of a Flu Year
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July 21st, 2009, 05:21 PM
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Re: Yamaguchi Japan Tamiflu Resistant Sequence Released
NA travel log
gb|GQ368668.1| Influenza A virus (A/Distrito Federal/2611/200... 34.2 2.9
gb|GQ365427.1| Influenza A virus (A/Iwate/1/2009(H1N1)) segme... 34.2 2.9
gb|GQ365412.1| Influenza A virus (A/Akita/1/2009(H1N1)) segme... 34.2 2.9
gb|GQ334348.1| Influenza A virus (A/Shizuoka/759/2009(H1N1)) ... 34.2 2.9
gb|CY041760.1| Influenza A virus (A/New York/3413/2009(H1N1))... 34.2 2.9
gb|GQ287628.1| Influenza A virus (A/Yokohama/1/2009(H1N1)) se... 34.2 2.9
gb|GQ287624.1| Influenza A virus (A/Shiga/3/2009(H1N1)) segme... 34.2 2.9
gb|GQ225351.1| Influenza A virus (A/Zhejiang/1/2009(H1N1)) se... 34.2 2.9
gb|DQ432046.1| Influenza A virus (A/swine/Fujian/2003(H5N1)) ... 34.2 2.9
gb|DQ432038.1| Influenza A virus (A/swine/Fujian/2001(H5N1)) ... 34.2 2.9
gb|AY651473.2| Influenza A virus (A/teal/China/2978.1/2002(H5... 34.2 2.9
gb|AY575883.2| Influenza A virus (A/Gs/HK/739.2/02 (H5N1)) ne... 34.2 2.9
gb|CY029169.1| Influenza A virus (A/quail/Shantou/3846/2002(H... 34.2 2.9
gb|CY029120.1| Influenza A virus (A/goose/Shantou/157/2002(H5... 34.2 2.9
gb|CY029085.1| Influenza A virus (A/duck/Shantou/5526/2001(H5... 34.2 2.9
gb|EF541469.1| Influenza A virus (A/Hong Kong/213/2003(H5N1))... 34.2 2.9
gb|EF541468.1| Influenza A virus (A/chicken/Viet Nam/Ncvd8/20... 34.2 2.9
gb|EF541465.1| Influenza A virus (A/duck/Viet Nam/Ncvd1/2002(... 34.2 2.9
gb|EF467813.1| Influenza A virus (A/teal/Hong Kong/2978/03(H5... 34.2 2.9
gb|EF124325.1| Influenza A virus (A/goose/Shantou/3624/2006(H... 34.2 2.9
gb|EF124312.1| Influenza A virus (A/goose/Shantou/2086/2006(H... 34.2 2.9
gb|EF124311.1| Influenza A virus (A/goose/Shantou/239/2006(H5... 34.2 2.9
gb|DQ997385.1| Influenza A virus (A/swine/Anhui/ca/2004(H5N1)... 34.2 2.9
gb|DQ997411.1| Influenza A virus (A/duck/Zhejiang/bj/2002(H5N... 34.2 2.9
gb|DQ997397.1| Influenza A virus (A/chicken/Hunan/fg/2004(H5N... 34.2 2.9
gb|DQ997183.1| Influenza A virus (A/chicken/Jiangsu/cz1/2002(... 34.2 2.9
gb|DQ191691.1| Influenza A virus (A/golden mountain thrush/Fu... 34.2 2.9
gb|DQ191690.1| Influenza A virus (A/curlew/Shandong/61/04(H5N... 34.2 2.9
gb|DQ188911.1| Influenza A virus (A/black bulbul/Fujian/439/0... 34.2 2.9
gb|DQ188910.1| Influenza A virus (A/slaty-backed gull/Shandon... 34.2 2.9
gb|DQ188909.1| Influenza A virus (A/babbler/Fujian/320/04(H5N... 34.2 2.9
gb|AY623431.1| Influenza A virus (A/chicken/Yichang/lung-1/04... 34.2 2.9
gb|AY747610.2| Influenza A virus (A/swine/Fujian/1/2003(H5N1)... 34.2 2.9
gb|AY747618.1| Influenza A virus (A/swine/Fujian/F1/2001(H5N1... 34.2 2.9
gb|AY585419.1| Influenza A virus (A/duck/Zhejiang/52/2000(H5N... 34.2 2.9
gb|AY575884.1| Influenza A virus (A/Eg/HK/757.3/02 (H5N1)) ne... 34.2 2.9
gb|AY575882.1| Influenza A virus (A/HK/213/03 (H5N1)) neurami... 34.2 2.9
gb|AY575881.1| Influenza A virus (A/HK/212/03 (H5N1)) neurami... 34.2 2.9
gb|DQ321057.1| Influenza A virus (A/Chinese pond heron/Hong K... 34.2 2.9
gb|DQ321055.1| Influenza A virus (A/grey heron/Hong Kong/728/... 34.2 2.9
gb|DQ321026.1| Influenza A virus (A/chicken/Guangxi/2448/2004... 34.2 2.9
gb|DQ321025.1| Influenza A virus (A/chicken/Guangxi/2439/2004... 34.2 2.9
gb|DQ321024.1| Influenza A virus (A/duck/Guangxi/2396/2004(H5... 34.2 2.9
gb|DQ321023.1| Influenza A virus (A/goose/Guangxi/2383/2004(H... 34.2 2.9
gb|DQ321022.1| Influenza A virus (A/duck/Guangxi/2291/2004(H5... 34.2 2.9
gb|DQ321021.1| Influenza A virus (A/goose/Guangxi/2112/2004(H... 34.2 2.9
gb|DQ321020.1| Influenza A virus (A/goose/Guangxi/1832/2004(H... 34.2 2.9
gb|DQ321019.1| Influenza A virus (A/duck/Guangxi/1793/2004(H5... 34.2 2.9
gb|DQ321018.1| Influenza A virus (A/duck/Guangxi/1681/2004(H5... 34.2 2.9
gb|DQ321017.1| Influenza A virus (A/duck/Guangxi/1586/2004(H5... 34.2 2.9
gb|DQ321016.1| Influenza A virus (A/duck/Guangxi/1378/2004(H5... 34.2 2.9
gb|DQ321015.1| Influenza A virus (A/duck/Guangxi/1311/2004(H5... 34.2 2.9
gb|DQ321014.1| Influenza A virus (A/goose/Guangxi/1198/2004(H... 34.2 2.9
gb|DQ321013.1| Influenza A virus (A/goose/Guangxi/1097/2004(H... 34.2 2.9
gb|DQ321012.1| Influenza A virus (A/goose/Guangxi/914/2004(H5... 34.2 2.9
gb|DQ321011.1| Influenza A virus (A/goose/Guangxi/668/2004(H5... 34.2 2.9
dbj|AB212056.1| Influenza A virus (A/Hong Kong/213/2003(H5N1)... 34.2 2.9
dbj|AB212282.1| Influenza A virus (A/duck/Yokohama/aq10/2003(... 34.2 2.9
gb|AY676042.1| Influenza A virus (A/egret/Hong Kong/757.2/03(... 34.2 2.9
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July 21st, 2009, 05:24 PM
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Editor, Senior Moderator
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Join Date: Mar 2006
Posts: 8,703
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Re: Yamaguchi Japan Tamiflu Resistant Sequence Released
Do all the sequences in the NA travel log have H274Y?
.
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"The next major advancement in the health of American people will be determined by what the individual is willing to do for himself"-- John Knowles, Former President of the Rockefeller Foundation
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July 21st, 2009, 05:26 PM
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Editor, Senior Moderator
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Re: Yamaguchi Japan Tamiflu Resistant Sequence Released
Since there is no New Jersey in that travel log, can we assume it is not the same NA as the 274Y-infected HK girl flying from San Francisco?
.
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"The next major advancement in the health of American people will be determined by what the individual is willing to do for himself"-- John Knowles, Former President of the Rockefeller Foundation
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July 21st, 2009, 05:30 PM
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Re: Yamaguchi Japan Tamiflu Resistant Sequence Released
Quote:
Originally Posted by AlaskaDenise
Do all the sequences in the NA travel log have H274Y?
.
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No, all of the sequences in the travel log have a recently acquired polymorphism found in Yamaguchi/22.
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July 21st, 2009, 05:33 PM
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Re: Yamaguchi Japan Tamiflu Resistant Sequence Released
Quote:
Originally Posted by AlaskaDenise
Since there is no New Jersey in that travel log, can we assume it is not the same NA as the 274Y-infected HK girl flying from San Francisco?
.
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Correct. This is H274Y on a different genetic background than the Hong Kong / San Francisco sequence or the Osaka sequence. The sequences from Denmark and Quebec have not been released.
Thus, at this time H274Y is on five isolates and no evidence has been presented to show that any of the five match each other.
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July 21st, 2009, 05:43 PM
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Editor, Senior Moderator
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Re: Yamaguchi Japan Tamiflu Resistant Sequence Released
Quote:
Originally Posted by niman
........at this time H274Y is on five isolates and no evidence has been presented to show that any of the five match each other.
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There shouldn't be any doubt influenza knows what it's doing. 
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July 21st, 2009, 06:02 PM
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Re: Yamaguchi Japan Tamiflu Resistant Sequence Released
Today, June 2nd, the first case of H1N1 influenza was confirmed in Yamaguchi Prefecture.
We are taking all possible measures as a prefecture in order to prevent the spread of infection, so we ask that everyone please act in a calm manner and act based upon accurate information.
http://www.pref.yamaguchi.lg.jp/cms/...ntmessage.html
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July 21st, 2009, 06:23 PM
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Re: Yamaguchi Japan Tamiflu Resistant Sequence Released
A PDF (in English) for each confirmed case in Yamaguchi is here
http://www.pref.yamaguchi.lg.jp/cms/...infection.html
None listed developed H1N1 while on Tamiflu.
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July 21st, 2009, 09:11 PM
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Re: Yamaguchi Japan Tamiflu Resistant Sequence Released
Niman,
Thanks for that link. They did a good job of including details on the patients; I wish more reports were like that.
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July 21st, 2009, 09:22 PM
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Re: Yamaguchi Japan Tamiflu Resistant Sequence Released
Quote:
Originally Posted by mixin
Niman,
Thanks for that link. They did a good job of including details on the patients; I wish more reports were like that.
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I think Japan and Hong Kong provide that type of detail (at least on the initial cases).
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July 21st, 2009, 09:25 PM
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Re: Yamaguchi Japan Tamiflu Resistant Sequence Released
Anti-flu drug "Tamiflu" avian flu virus was found to be resistant gene variant (A/H1N1) for confirmation of
平成21年 (2009年) 7月 17日 July 17, 2009
本県で確認された患者から、「タミフル」耐性を示す遺伝子変異を持つ新型インフルエンザウイルスが確認され 、国に報告しましたので、お知らせします。 Chiayi County has been identified in patients, "Tamiflu" was confirmed with a mutated avian flu virus showing resistance gene, have been reported in the country, and then let us know.
なお、厚生労働省によれば、タミフルに対する耐性を持つ遺伝子変異は、ウイルスの重篤度（病原性）には直接 影響を及ぼすものではないとされています。 However, according to the ministry, with the mutant gene are resistant to Tamiflu, the severity of the virus (pathogenic) is a direct influence is not.
ウイルス検出の概要 Overview of viral detection
○ 山口県で確認された患者から、タミフル耐性を示す遺伝子変異を持つ新型インフルエンザウイルスが検出さ れた。 ○ from a patient who was confirmed in Yamaguchi Prefecture, was found with avian flu virus resistant to Tamiflu indicates the gene mutation.
その後、この患者から周囲への感染拡大は認められていない。 Then, to spread around the patient is not approved.
○ 国立感染症研究所によって実施された検査結果は、以下のとおりである。 ○ test results conducted by the National Institute of Infectious Diseases, is as follows.
遺伝子解析 Genome
ノイラミニダーゼ（NA）遺伝子の一部に、H275Yの突然変異を確認した。 Neuraminidase (NA) of the gene, H275Y mutation was confirmed.
季節性インフルエンザ（Ａ/Ｈ１Ｎ１：ソ連型） との交雑は認めない。 Seasonal influenza (A/H1N1: Soviet-type) and do not cross.
薬剤感受性試験 Drug susceptibility testing
・ オセルタミビル（商品名：タミフル）：薬剤耐性あり（感受性低下を認める） Oseltamivir (product name: Tamiflu): with drug resistance (decreased sensitivity to admit)
・ ザ ナ ミ ビ ル（商品名：リレンザ）：薬剤感受性あり The Big Le Mi Na (Product name: Relenza): In drug-sensitive
http://translate.google.com/translat...%26tbs%3Dqdr:m
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July 22nd, 2009, 01:42 PM
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Re: Yamaguchi Japan Tamiflu Resistant Sequence Released
Quebec finds first, Japan finds second cases of Tamiflu-resistant swine flu
By Helen Branswell (CP) – 1 hour ago
TORONTO — Canada has recorded a case of Tamiflu-resistant swine flu virus, in a Quebec man who had been given the drug to prevent infection.
Meanwhile, Japan revealed Tuesday it had found a second such case of Tamiflu resistance, in a person who has no ties to the country's earlier reported case.
The cases are the fourth and fifth globally since the new H1N1 virus was discovered in April.
The Quebec man, 60, was given the flu antiviral after his son fell ill with the pandemic virus. It's believed the resistance arose in the man and there is no evidence he transmitted resistant virus to anyone else.
"It appears to be an isolated case," said Jirina Vlk, spokesperson for the Public Health Agency of Canada.
"Although the strain does not appear to have spread beyond the reported individual case we continue to be vigilant on this front."
Use of Tamiflu to prevent infection - a procedure called prophylaxis - has been seen on occasion to give rise to resistant viruses.
"We know that it was going to happen and it's not good news that it's happening," said Dr. Allison McGeer, an influenza expert at Toronto's Mount Sinai Hospital.
But she said given the amount of Tamiflu being used in the world right now, such cases are bound to arise.
"It's the problem with influenza, right? Either we're going to see small numbers of these and they're just going to kind of appear periodically and we're all going to worry or it's going to go big," McGeer said.
"There's probably not going to be much in between."
Another such case cropped up in Japan, in the city of Yamaguchi. Japan's National Institute of Infectious Diseases logged genetic sequence data for the virus on Tuesday in Genbank, a repository for genetic sequences used by flu researchers.
The lab's director, Dr. Masato Tashiro, confirmed the case in an email containing details provided to the World Health Organization.
The new case was a person who had been given the antiviral drug as post-exposure prophylaxis - an attempt to prevent illness in a person exposed to the pandemic virus.
The person has since recovered, and it appears that there has been no spread, the email stated. The virus was sensitive to Relenza, a second drug in the same class as Tamiflu.
The earlier Japanese case had occurred in a person in the city of Osaka.
Other cases have been reported by Denmark and Hong Kong. Four of the five cases arose in people who had been taking the drug.
One, however, was recorded in a girl from San Francisco who travelled while sick to Hong Kong. Health inspectors at the airport there pulled her aside and tested her for swine flu.
She was positive, but told doctors there she hadn't taken Tamiflu. That suggests the virus that caused her infection was already resistant. U.S. officials have intensified surveillance for resistant viruses in the San Francisco area but say they have not found other cases.
The Public Health Agency says the Quebec man recovered from his bout of swine flu without complications and never needed hospitalization.
Vlk said the agency recommends using Tamiflu for treatment only, adding prudent use of the drug could stave off the development of resistance.
Follow Canadian Press Medical Writer Helen Branswell's flu updates on Twitter at CP-Branswell
http://www.google.com/hostednews/can...nwA_JRXyesKjAQ
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July 23rd, 2009, 09:09 AM
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Posts: 30
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Re: Yamaguchi Japan Tamiflu Resistant Sequence Released
It's clearly different from osaka/180.
HA relates to what is found in new york.
NA has a polimorphism (254 AAA) that is found in the following h1n1 sequences:
Quote:
A/Akita/1/2009(H1N1)
A/Distrito Federal/2611/2009(H1N1)
A/Iwate/1/2009(H1N1)
A/New York/3413/2009(H1N1)
A/Shiga/3/2009(H1N1)
A/Shizuoka/759/2009(H1N1)
A/Yamaguchi/22/2009(H1N1)
A/Yokohama/1/2009(H1N1)
A/Zhejiang/1/2009(H1N1)
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hong kong/2369, osaka/180 and yamaguchi/22 all share this polymorphism (H274Y) but have different genetic backgrounds.
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Disclaimer:
The reader is responsible for discerning the validity, factuality or implications of information posted here, be it fictional or based on real events. Moderators on this forum make every effort to review the material posted on this site however, it is not realistically possible for our staff to manually review each post.
The content of posts on this site, including but not limited to links to other web sites, are the expressed opinion of the original authors or posters and are not endorsed by, or representative of the opinions of, the owners or administration of this website. The posts on this website are the opinion of the specific author or poster and should not be construed as statements of advice or factual information.
Not all posts on this website are intended as truthful or factual assertion by their authors. NO posts on this website should be considered factual information on face value alone. Users are encouraged to USE DISCERNMENT and do their own follow up research while reading and posting on this website. FluTrackers.com Inc. reserves the right to make changes to, corrections and/or remove entirely at any time posts made on this website without notice. In addition, FluTrackers.com Inc. disclaims any and all liability for damages incurred directly or indirectly as a result of a post on this website.
This site is provided "as is" without warranty of any kind, either expressed or implied. You should not assume that this site is error-free or that it will be suitable for the particular purpose which you have in mind when using it. In no event shall FluTrackers.com Inc. be liable for any special, incidental, indirect or consequential damages of any kind, or any damages whatsoever, including, without limitation, those resulting from loss of use, data or profits, whether or not advised of the possibility of damage, and on any theory of liability, arising out of or in connection with the use or performance of this site or other documents which are referenced by or linked to this site.
Finally, FluTrackers.com Inc. reserves the right to delete, correct, or make changes to any post on this website without notice at any time for any reason.
Fair Use Notice:
This site may contain copyrighted material the use of which has not always been specifically authorized by the copyright owner. Users may make such material available in an effort to advance awareness and understanding of issues relating to public health, civil rights, economics, individual rights, international affairs, liberty, science & technology, etc. We believe this constitutes a 'fair use' of any such copyrighted material as provided for in section 107 of the US Copyright Law. In accordance with Title 17 U.S.C.Section 107, the material on this site is distributed to those who have expressed a prior interest in receiving the included information for research and educational purposes.
In accordance with industry accepted best practices we ask that users limit their copy / paste of copyrighted material to the relevant portions of the article you wish to discuss and no more than 50% of the source material, provide a link back to the original article and provide your original comments / criticism in your post with the article. Please remember you are responsible for what you post on the internet and you could be sued by the original copyright holder if you do not honor these rules.
If you are a legal copyright holder or a designated agent for such and you believe a post on this website falls outside the boundaries of "Fair Use" and legitimately infringes on yours or your clients copyright
we may be contacted concerning copyright matters at:
FluTrackers.com Inc.
c/o Sharon Sanders
1676 Hibiscus Avenue
Winter Park, Florida 32789
Phone: 407-406-3037
E-Mail: flutrackers@earthlink.net
In accordance with section 512 of the U.S. Copyright Act our contact information has been registered with the United States Copyright Office. "Safe Harbor" noticing procedures as outlined in the DMCA apply to this website concerning all 3rd party posts published herein.
If notice is given of an alleged copyright violation we will act expeditiously to remove or disable access to the material(s) in question.
All 3rd party material posted on this website is the copyright of the respective owners / authors. FluTrackers.com Inc. makes no claim of copyright on such material.
For more information please visit:
http://www.law.cornell.edu/uscode/17/107.shtml
Please be aware any communications sent complaining about a post on this website may be posted publicly at the discretion of the administration.
FluTrackers Does Not Provide Any Medical Advice:
FluTrackers, Inc. does not provide medical advice. Information on this web site is collected from various internet resources, and the FluTrackers board of directors makes no warranty to the safety, efficacy, correctness or completeness of the information posted on this site by any author or poster.
The information collated here is for instructional and/or discussion purposes only and is NOT intended to diagnose or treat any disease, illness, or other medical condition. Every individual reader or poster should seek advice from their personal physician/healthcare practitioner before considering or using any interventions that are discussed on this website.
By continuing to access this website you agree to consult your personal physican before using any interventions posted on this website, and you agree to hold harmless FluTrackers.com Inc., the board of directors, the members, and all authors and posters for any effects from use of any medication, supplement, vitamin or other substance, device, intervention, etc. mentioned in posts on this website, or other internet venues referenced in posts on this website.
By using and/or accessing this site, either passively or actively, you are agreeing to all of the above conditions. Also, by using and/or accessing this site, either passively or actively, you agree to conduct all business and legal affairs related to this website in the jurisdiction of Flutrackers.com Inc. which is registered in Central Florida, USA.
These Disclaimers are subject to change at anytime.
Email the Webmaster with questions or comments about this site at flutrackers@earthlink.net
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