Mutation of the H1N1 influenza virus was detected in Mexico since April

[Tonka]

http://www.jornada.unam.mx/2009/11/27/index.php?section=sociedad&article=037n1soc

Mutation of the H1N1 influenza virus was detected in Mexico since April, according to Indre
More cases will be sought through genetic sequencing of samples of the strain: Celia Alpuche


Pregnant workers and 28 of the IMSS clinic, located in San Borja Gabriel Mancera and were vaccinated against influenza yesterday A/H1N1Foto Victor Camacho
?ngeles Cruz Martinez

La Jornada
Friday, 27 November 2009, p. 37
The mutation of the H1N1 influenza virus reported by Norway was also found in Mexico, but since April, one of the first ill patients treated at the National Institute of Respiratory Diseases (INER). So far there is no evidence that such change conditional aggressiveness of the disease, said Celia Alpuche, director of the Institute of Epidemiological Diagnosis and Reference (Indre).

He said the recommendation of the World Health Organization (WHO) countries where the mutation has been found will look for other cases by genetic sequencing of samples of the strain.

In Mexico, the procedure will begin next week with 50 samples found in the Indre people died from the new flu, those patients who were serious and 10 percent of outpatients.

In an interview during a forum on genomic medicine and infections organized by the National Institute of Public Health, the official explained that the mutation is located in a segment of the hemagglutinin (a protein found on the surface of the virus), which is an amino acid different to that shown in the H1N1 strain.

Moreover, the Mexican Social Security Institute (IMSS) announced the start of the implementation of the new flu vaccine. The first batch consists of 299 thousand doses, which apply to medical personnel who have contact with those affected by the infection, women in the third trimester of pregnancy, children six to 24 months old and caregivers of infants under 6 months.

The agency purchased 12 million doses of the biological and deal with the outbreak of influenza in the winter season has 280 thousand antiviral treatments. In relation to the conduct of the pandemic, noted that in the past week was a decrease of almost 50 per cent in the number of cases.
Alpuche confirmed this information: "the curve of cases seems to have entered a plateau, mainly in the states of central and northern Iraq, but could rise again in other regions," he said.

With respect to the mutation of H1N1 virus, the specialist said the case reported by Mexico was for the second patient treated at the INER grave, who died. He said the Indre made 29 genetic sequencing of the eight most important genes of the strain in different individuals, and found only one variation.
The same mutation has also been detected in the United States, China and Brazil, among others. In recent days the information gained relevance because Norway the first found. When this happened the WHO requested information to other nations about the clinical characteristics of patients and found that some had been severe and mild cases.

Hence, it is impossible to conclude whether this change affects the severity of the infection.

Sporadic resistance to antivirals: WHO

WHO reported that since the emergence of the pandemic have presented 75 cases of resistance to the antiviral oseltamivir, of which nine were located in Wales (United Kingdom) and four in North Carolina (United States).

In conference in Geneva, Switzerland, Keiji Fukuda, special adviser on pandemic international agency, said some of these patients also carry HIV / AIDS.

He noted that the cases are sporadic resistance to the antiviral and help overcome the new flu. "So far there has been a change in the epidemiology of the disease," said the expert.

Antivirals are still effective if given in a timely and correct, he said.

[Tonka]

Re: Mutation of the H1N1 influenza virus was detected in Mexico since April

http://www.milenio.com/node/329888

Discover first case of mutation of the A (H1N1) in Mexico: Indre
The head of the Institute of Epidemiological Diagnosis and Reference for instructions said that WHO will begin next week a methodology designed to sequence the body quickly and to determine if there are more cases with mutation of the virus, and if severe or mild.

Thu, 26/11/2009 - 20:22
Mexico City .- In Mexico, the first case of mutation of human influenza virus A (H1N1), which corresponds to reports of deaths and April when the epidemic began in the country, said the director of the Indre, Celia Alpuche Aranda.

The head of the Institute of Epidemiological Diagnosis and Reference (Indre) said that next week will begin a methodology designed to sequence the body quickly and to determine if there are more cases with mutation of the virus, and if severe or mild.

In an interview, Alpuche Aranda explained that the research was applied to all countries by the World Health Organization, as well as Mexico cases have also been found in Brazil, China and the U.S..

The case in Mexico for the second patient who was treated seriously at the National Institute of Respiratory Diseases, which was compared with three other cases were registered in the U.S., but in mild patients.

On that occasion, the WHO determined that it was not a particular situation, but in days past in Norway were reported serious cases of humans catching the disease and the virus mutated, so that all countries begin to look carefully if there are more records .

Alpuche Celia explained that no consensus has been reached within the WHO that can truly confirm an increased virulence of the A (H1N1), it has been found in critically ill patients but also mild.

'The WHO statement is that as of November 20 start looking carefully at a random sampling if this is truly associated. We asked him all countries, "said the director of the Indre.

He reported that in response to this request, the responsible institution designed a methodology to search for this sequencing in cases of hospitalization, in addition to analyze 50 samples he has of deaths from this virus,

This sequencing, detailed, starting next week and will be in 10 percent of outpatient cases that have reached the Indre, in hospital and deaths in the samples they already have.

The mutation such as that suffered human influenza is almost considered normal, since the proliferation of such viruses have the ability to make very specific changes that are not normally aggressive to provoke more or less virulence.

However, that does not happen when the changes are in the role of viruses, which are called genetic rearrangement of genes, and that's when more virulent and even resistance to antiviral medicines or treatments.

Alpuche Aranda said that until now there is a drastic change in the genetics of viruses, so that will be made and follow-up studies to search for global consensus and determine how the mutation was virulent.

Notimex

[Tonka]

Re: Mutation of the H1N1 influenza virus was detected in Mexico since April

http://www.elsiglodetorreon.com.mx/noticia/481036.confirman-mutacion-del-virus-a-h1n1-en-mexico.html

Confirm H1N1 virus mutated in Mexico
In: ESTATE / MEXICO CITY .-
Mexico detected since the beginning of the epidemic, a mutation of the influenza A H1N1 virus as reported by the Norwegian authorities, said the director of the Institute of Epidemiological Diagnosis and Reference (InDRE), Celia Alpuche.

According to the charge of the laboratory that analyzed the bulk samples of the new virus in the country, the mutation was found in April in the second patient of the disease confirmed by the National Institute of Respiratory Diseases (INER), which eventually died .

However, he said Alpuche, still no international consensus on the aggressiveness of this variant of influenza A H1N1, since there are countries that have been found in critically ill patients and in patients with mild symptoms.

"This mutation is found from the beginning just a patient here in Mexico. At that time the analysis was with the United States did not reach any conclusion because they found it in patients with mild disease," he said in an interview.

"Why now becomes important?, Because the Norwegians found it in seriously ill patients. What did the World Health Organization (WHO)? We again ask all the clinical characteristics of patients who have presented .

The specialist said that so far there have been 29 complete genetic sequences of the same number of patients and found only one case with mutation.

However, at the request of WHO, InDRE shall increase the number of sequences to investigate whether the mutation might have arisen in most patients.

NO REPORTS

Meanwhile, Keiji Fukuda, special adviser on the WHO pandemic influenza, said yesterday that it has reports of a mutated H1N1 virus in Mexico.
"I know of reports of this mutation in Mexico. Maybe we'll hear of such reports later, but for now have no record. We have reports from countries like Brazil, China, Japan, Norway, Ukraine, United States," he said in press teleconference from Geneva.

APPLIED VACCINE

Meanwhile, the Mexican Social Security Institute (IMSS) officially started vaccination against influenza virus A H1N1 nationwide.
Toumeh Daniel Karam, director general of the IMSS, witnessed the implementation of the new vaccine institute three nurses and a person entitled, in their last trimester of pregnancy.

Before nurses who gathered at the Hospital Zone 2 of Aguascalientes, Daniel Karam said that health personnel should be the solution and not part of the problem. Hence, he added, that this group is the first to be vaccinated.

He said that since yesterday and today during all delegations to the national Social Security with the antigen will first be applied to medical personnel and pregnant women were later to children six to 24 months and then ill persons chronic high risk of acquiring this disease.

'There is no record of infected twice'
Jose Angel Cordova Villalobos, head of the Health Secretariat (SSA), said that in Mexico there have been no cases of people who have fallen ill twice by the influenza virus A H1N1, as has happened in the U.S., as unveiled the Center for Disease Control and Prevention (CDC) of that nation.

"Chances are that this is another virus, but not the A H1N1," he said, while acknowledging that when a person gets sick from this virus, as with other diseases, your body is "sense" to acquire any other infection.

[Tonka]

Re: Mutation of the H1N1 influenza virus was detected in Mexico since April

http://www.proceso.com.mx/noticias_articulo.php?articulo=74297

Discard WHO H1N1 virus mutated in Mexico
THE EDITOR
MEXICO CITY, Nov. 26 (approved) .- The World Health Organization (WHO) today ruled that similar cases occur in Mexico with the same mutation in the influenza A/H1N1 virus was found in Norway in three patients with severe.

At a press conference in Geneva, Switzerland, the special adviser on Pandemic, Keiji Fukuda said he had no report to that change in Mexico. "Maybe we'll hear of such reports later, but for now I have no reports about this," he said.

However, the head of the Ministry of Health Jos? ?ngel C?rdova Villalobos, acknowledged that in Mexico there were cases detected by this mutation, there were patients who had the virus 'mutant' with a very mild illness, some moderate and severe, or that is, not related to the aggressiveness of the virus, now there is no concern in our country and generally in the world for these small changes that have occurred.

At a press conference at the end of the opening of the Twelfth Regular Meeting of the National Health Council, held in Aguascalientes, the federal official added that mutations in the virus have been watching, "but only in part of the genome , which does not affect the sensitivity of the virus to the antiviral or the sensitivity or reactivity that may have the vaccine. "

Separately, the National Commissioner for Influenza Care, Alejandro Mac?as, said the virus has undergone not one but many mutations, "is always mutating.

"The last one was reported, which has made more news, is that of Norway, but this does not imply resistance to antivirals, or greater transmissibility or difficulties in their diagnosis, and the only indication is that it might be more invasive and more lethal "he said.

It also announced that the federal government has a "small strategic reserve" of over 100 thousand zanavimir where in Mexico following a finding of resistance to Tamiflu, as a result of mutations that has experienced the A/H1N1 virus .

In an interview, Macias said that if there was a mutation that causes a resistance to Tamiflu, "would be changed by another antiviral, and Mexico is ready with a reserve of 100 thousand alternating zanavimir treatments, though still small, but we used to cope . At present we are not faced that situation. "

In Aguascalientes, Cordova Villalobos, who said that to date there are 65 thousand registered 99 confirmed cases and 610 deaths from the virus nationwide, said that the country there have been no cases of people who have fallen ill twice influenza A/H1N1 virus, as has happened in America.

"Chances are that this is another virus, but not H1N1," he said, acknowledging that when a person gets sick from this virus, as with other diseases, your body is "meaning" to acquire any other infection.

It also announced that is expected to be in the last 15 days in December and the first weeks of January when it has the "highest point" of human influenza cases, because in dry faster transmitting the virus.

"There will be more cases and more deaths, but the important thing is to contain them," the health minister