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  • Concern grows over drug-resistant H5N1 mutations

    Tuesday ,Mar 23,2010, Posted at: 13:48(GMT+7)

    Medical experts are growing increasingly worried that the bird flu virus (A/H5N1) is showing signs of transforming into more lethal forms, since the number of cases in Vietnam since the beginning of the year is equal to all those of 2009.
    <table align="right" border="0" cellpadding="3" cellspacing="0" width="1"> <tbody> <tr> <td> </td></tr> <tr> <td class="Image">Medical workers advise people to wear protective clothing and wash their hands after coming into contact with poultry</td></tr></tbody></table>
    The Department of Preventive Health and Environment, a sub-division of the Ministry of Health, has reported five H5N1 infections in the country since January 1 including two deaths. A 38-year-old woman from southern Tien Giang Province and a three-year-old from Binh Duong Province both succumbed to the illness.
    Dr. Nguyen Huy Nga, head of the Department of Preventive Health and Environment, said the increase in infections highlights the complexity of the disease’s development.
    Health workers are also concerned over the critical condition of a 25-year-old female in Hanoi’s Soc Son District who is currently being treated for bird flu at the National Tropical Disease Hospital. Unlike other cases, the woman reportedly had not had contact with diseased or dead waterfowl or eaten poultry before falling ill.
    Dr. Nguyen Quynh Mai from the National Institute of Hygiene and Epidemiology, said research has revealed seven new A/H5N1 virus strains in Vietnam. Tests show the strains are drug-resistant and potentially lethal.
    Dr. Nga said that low public awareness could lead to more lethal strains of both bird flu and swine flu (A/H1N1). He warned health agencies to strengthen supervision of flu outbreaks in communities to quickly isolate infected patients from coming into contact with other people.
    Residents should report to local governments immediately when chickens die or show signs of disease for unclear reasons, he said. In addition, people should wear protective clothing and wash their hands after coming into contact with poultry.
    Anyone suffering fever, cough or breathing problems is advised to seek immediate medical treatment.

    <table id="table1" bordercolordark="#008000" bordercolorlight="#008000" bgcolor="#ccffcc" border="1" width="100&#37;"> <tbody> <tr> <td>US to provide VN with $100,000 worth of flu-response gear

    The US Government March 22 announced it would provide Vietnam with more than 11,000 sets of personal protective equipment and four laboratory kits to help health workers respond quickly to potential new outbreaks of avian and swine influenza.

    The assistance package worth US$100,000 and implemented by the US Agency for International Development (USAID), comes at the request of Vietnam's Ministry of Health, with technical support from the World Health Organization.

    The supplies are being sent to regional hygiene and epidemiology institutes and Pasteur Institutes and provinces throughout the country most at risk of bird flu or in greatest need of the supplies, which include such items as protective suits, masks, gloves, infection testing swabs.
    </td></tr></tbody></table>


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  • #2
    Re: Concern grows over drug-resistant H5N1 mutations

    I think that is the first English language article on the subject. Maybe I'm wrong...but I've been waiting for one...this was not translated.

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    • #3
      Re: Concern grows over drug-resistant H5N1 mutations

      I was wrong! Here is an article from the same site. It's from the English edition of Saigon-gpdaily.com

      Sunday ,Mar 21,2010, Posted at: 12:36(GMT+7)
      <table border="0" cellpadding="0" cellspacing="0" width="497"><tbody><tr> <td>

      </td> </tr> <tr> <td> Research shows bird flu could become more deadly
      </td> </tr> <tr> <td> Recent research shows rapid changes have occurred to the bird flu virus (A/H5N1), which could lead to a more deadly, drug-resistant strain of the disease, the Virus Department of the National Institute for Hygiene and Epidemiology has reported.
      <table align="right" border="0" cellpadding="3" cellspacing="0" width="1"> <tbody> <tr> <td> </td></tr> <tr> <td class="Image"> Doctors examine patients contracted with A/H1N1 in Bac Kan Hospital. (Photo: VNA)
      </td></tr></tbody></table>
      Dr. Nguyen Huy Nga, head of the Preventive Health and Environment Department, said that at least seven antigen groups have appeared in the bird flu virus since it was first detected in Vietnam, and that the virus?s future development would be hard to predict.
      She made the announcement on March 12 during a national conference in Hanoi on avian influenza.
      However, the ability to transmit the virus from human to human remains low, Dr. Nga said.
      She also warned that a bird flu (A/H5N1) epidemic is at high risk of recurrence due to poor pubic awareness of the disease.
      Dr. Nguyen Tran Hien, director of the Virus Department of the National Institute for Hygiene and Epidemiology, said that in addition to raising awareness about genetic mutations related to the bird flu virus, people must be educated about how to prevent the disease.
      Dr. Nga said that in remote areas, local people still slaughter and eat meat from sick chickens. This may cause the disease to spread further, she added.
      The Environment and Preventative Medicine Department has asked people to take strict measures to prevent another outbreak of A/H5N1. The department also stressed the need to tighten control of poultry transport, trading and slaughtering activities.
      Anyone who suspects they may have contracted bird flu is advised to seek immediate medical treatment, the department added.
      According to experts, the most effective measure to prevent an outbreak of the deadly disease is to promote information dissemination. Public awareness of the virus has remained relatively low since bird flu first broke out in Vietnam seven years ago.
      Since the beginning of this year, five people in Vietnam have contracted the A/H5N1 virus, of whom two died.
      Bird flu has claimed the lives of 60 people in Vietnam since December 2003.

      </td></tr></tbody></table>
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      • #4
        Re: Concern grows over drug-resistant H5N1 mutations

        Dr. Nguyen Quynh Mai from the National Institute of Hygiene and Epidemiology, said research has revealed seven new A/H5N1 virus strains in Vietnam. Tests show the strains are drug-resistant and potentially lethal.
        Dr. Nguyen Quynh Mai is the first one to say this specifically.

        Seperate from Dr. Nguyen Huy Nga, head of the Preventive Health and Environment Department.....and....Dr. Nguyen Tran Hien, director of the Virus Department of the National Institute for Hygiene and Epidemiology.....

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        • #5
          Re: Concern grows over drug-resistant H5N1 mutations

          #3: "Recent research shows rapid changes have occurred to the bird flu virus (A/H5N1)"

          thanks Common., but
          that are bad news indeed


          anybody could from somewhere shed more light to the characteristics of such changes?

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          • #6
            Re: Concern grows over drug-resistant H5N1 mutations

            Clarification on what they mean by 'likely to be drug resistant' would be welcome. The implication is that avian strains circulating in birds are carrying oseltamivir resistance markers. I hope I am wrong.

            Comment


            • #7
              Re: Concern grows over drug-resistant H5N1 mutations

              Originally posted by Commonground View Post
              Dr. Nguyen Quynh Mai is the first one to say this specifically.

              Seperate from Dr. Nguyen Huy Nga, head of the Preventive Health and Environment Department.....and....Dr. Nguyen Tran Hien, director of the Virus Department of the National Institute for Hygiene and Epidemiology.....
              or this doctor....All of the articles that Treyfish & I have posted over the past week, have said there were changes in the antigen that "reduces" the sensitivity to drug treatment flu. But the above doctor, seemed to specifically state this...I'm a little leery right now, as to it being "fact". I don't believe at this point it is fact.

              TS L? Quỳnh Mai, Trưởng khoa virus, Viện Vệ sinh dịch tễ trung ương cho biết, qua ph?n lập hơn 300 virus c?m A/H5N1 tr?n gia cầm v? người bệnh tại Việt Nam, đ? ph?t hiện c? ?t nhất 7 nh?m kh?ng nguy?n tr?n virus c?m kể từ khi loại virus n?y c? mặt tại nước ta.
              Dr Le Quynh Mai, viruses Dean, Institute of Hygiene and Epidemiology said central, isolated by more than 300 influenza A/H5N1 virus in poultry and the disease in Vietnam, has discovered at least seven group antigens on virus since the virus is present in our country.

              In particular, the recognition is the evolution of the gene segments of genes between different virus, can also detect the exchange and integration between the influenza A/H5N1 virus circulating in our country .
              Hơn nữa, c?c ph?n t?ch về ph?n tử di truyền virus c?m A/H5N1 cũng cho thấy sự tiến h?a nhanh của virus n?y v? đều thuộc chủng độc lực cao, c? những sự thay đổi của kh?ng nguy?n l?m giảm độ nhạy của thuốc điều trị c?m.
              Moreover, analysis of molecular genetic influenza A/H5N1 virus also showed rapid evolution of this virus and are of highly pathogenic strains, there are changes of the antigen reduces the sensitivity of the drug treatment flu.
              http://translate.googleusercontent.c...r_NKs-4rQy0drg

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              • #8
                Re: Concern grows over drug-resistant H5N1 mutations

                Agreed - need genetic sequencing or publication of sensitivity assays to confirm either way... but lets keep eyes out for such confirmation.

                Even if true it does not necessarily mean a human H5N1 pandemic strain would be drug resistant - there are many clades around that could be involved in that jump, and I dont believe we have seen similar reports from say Indonesia or Egypt as yet. Well done CG

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                • #9
                  Re: Concern grows over drug-resistant H5N1 mutations

                  Same Quynh Mai

                  A Community Cluster of Oseltamivir-Resistant Cases of 2009 H1N1 Influenza

                  Le Quynh Mai, M.D., Ph.D.
                  National Institute of Hygiene and Epidemiology Hanoi, Vietnam

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