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J Gen Virol. 2010 Jun;91(Pt 6):1461-3. Epub 2010 Feb 3.
A mutation in H5 haemagglutinin that conferred human receptor recognition is not maintained stably during duck passage.
Shinya K, Makino A, Hatta M, Watanabe S, Kim JH, Kawaoka Y.
Division of Zoonosis, Department of Microbiology and Infectious Diseases, Graduate School of Medicine, Kobe University 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, Japan. kyoko.tanaka@aioros.ocn.ne.jp
Abstract
A/Hong Kong/213/97 (HK213; H5N1), isolated from a human, binds to both avian- and human-type receptors, due to a haemagglutinin (HA) mutation probably acquired during adaptation to humans. Duck passage of this virus conferred lethality in ducks. Sequence analyses of the duck-passaged virus revealed that its HA gene reverted back to one recognizing only avian-type receptors, and consequently it bound human tissue to a lesser extent. This finding suggests that viruses with human-type receptor specificity are unlikely to be maintained in waterfowl, unlike those with the human-type PB2 mutation, such as H5N1 viruses of the Qinghai Lake lineage.
PMID: 20130132 [PubMed - indexed for MEDLINE]
A mutation in H5 haemagglutinin that conferred human receptor recognition is not maintained stably during duck passage.
Shinya K, Makino A, Hatta M, Watanabe S, Kim JH, Kawaoka Y.
Division of Zoonosis, Department of Microbiology and Infectious Diseases, Graduate School of Medicine, Kobe University 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, Japan. kyoko.tanaka@aioros.ocn.ne.jp
Abstract
A/Hong Kong/213/97 (HK213; H5N1), isolated from a human, binds to both avian- and human-type receptors, due to a haemagglutinin (HA) mutation probably acquired during adaptation to humans. Duck passage of this virus conferred lethality in ducks. Sequence analyses of the duck-passaged virus revealed that its HA gene reverted back to one recognizing only avian-type receptors, and consequently it bound human tissue to a lesser extent. This finding suggests that viruses with human-type receptor specificity are unlikely to be maintained in waterfowl, unlike those with the human-type PB2 mutation, such as H5N1 viruses of the Qinghai Lake lineage.
PMID: 20130132 [PubMed - indexed for MEDLINE]
