Egyptian girl dies of bird flu / mother also in hospital

[Dutchy]

Egyptian girl dies of bird flu - agency

05 Feb 2007 20:13:11 GMT

Source: Reuters

CAIRO, Feb 5 (Reuters) - A 17-year-old Egyptian girl has died of the H5N1 bird flu virus, the 12th Egyptian to die of the virus, the state news agency MENA reported on Monday.

MENA identified the girl as Nouri Nadi from Fayyoum province south of the Egyptian capital.

An official for the World Health Organisation in Egypt, which normally can confirm bird flu cases, said he had not been informed by Egypt's Health Ministry of a confirmed new death from bird flu.

http://www.alertnet.org/thenews/newsdesk/L05617979.htm

credits Christian

[Dutchy]

WHO confirms Egyptian girl dies of bird flu

05 Feb 2007 20:39:43 GMT

CAIRO, Feb 5 (Reuters) - An Egyptian girl has died of bird flu south of Cairo, bringing the number of confirmed deaths from the disease in Egypt to 12, a World Health Organisation official said on Monday.

The girl has been identified as Nouri Nadi, 17, of Fayyoum province. The WHO official said the girl was believed to have been infected after coming into contact with sick and dead birds.

http://www.alertnet.org/thenews/newsdesk/L05803351.htm

[HenryN]

Commentary at

http://www.recombinomics.com/News/02...1_Egypt_6.html

[AlaskaDenise]

Originally Posted by niman

Commentary at

http://www.recombinomics.com/News/02...1_Egypt_6.html

Commentary

Sixth Qinghai H5N1 Fatality in Egypt
Recombinomics Commentary
February 5, 2007

The girl has been identified as Nouri Nadi, 17, of Fayyoum province. The WHO official said the girl was believed to have been infected after coming into contact with sick and dead birds.

The above comments describe the sixth confirmed H5N1 case in Egypt. All six cases have died. Three of the fatalities were family members from Gharbiya. Sequences from two indicated they had the Tamiflu resistance marker, N294S, which was present prior to treatment.

The patients also had HA M230I, which was also in the first case this season. M230I has also been seen in the H7N3 outbreak in England as well as recent poultry isolates in Egypt.

However, the 2007 case from Beni Suef, which is geographically close to the case described above and did not have M230I or the Tamiflu resistance marker, N294S.

More information on the sequences from the Fayyoum fatality would be useful.


.

[Dutchy]

Egyptian girl dies of bird flu, country's 12th avian flu death

The Associated PressPublished: February 5, 2007


CAIRO, Egypt: A 17-year-old Egyptian girl has died of bird flu, the country's 12th death from the avian flu strain, the state-run news agency reported Monday.

The girl, identified as Nora Nadi from the city of Fayoum, about 70 kilometers (43.5 miles) south of Cairo, had tested positive for H5N1 strain, the Middle East News Agency reported.

Nadi was admitted to hospital a week ago, Health Ministry official Abdel Rahman Chahine told MENA. The news agency did not say how Nadi contracted the virus, but other Egyptians have become ill after coming in contact with infected birds that are raised at home or while slaughtering or cleaning chicken.

Twenty people have been infected with the deadly H5N1 strain in Egypt so far. Of the 12 deaths, 11 have been women. In Egypt, women and girls tend to look after chickens and turkeys kept in backyards, making them more vulnerable to avian flu.

Bird flu was first detected in Egypt in February 2006 and has spread to at least 19 of the country's 26 provinces.

The H5N1 strain has hit at least 45 countries and killed more than 150 people worldwide. The discovery of avian flu in the Middle East has led to widespread culling of birds.

The World Health Organization has reported that mutations in the virus have been found in two fatalities in Egypt, in a form that might be resistant to Tamiflu, a drug also known as oseltamivir most commonly used to treat the disease.

The WHO said the mutations were not drastic enough to spark a pandemic, but more mutations could prompt scientists to rethink current treatment strategies.

http://www.iht.com/articles/ap/2007/...t-Bird-Flu.php

[Dutchy]

WHO confirms Egyptian girl dies of bird flu

05 Feb 2007 21:01:12 GMT
Source: Reuters

(Adds details, background)

CAIRO, Feb 5 (Reuters) - An Egyptian girl has died of bird flu south of Cairo, bringing the number of confirmed deaths from the disease in Egypt to 12, a World Health Organisation official said on Monday.

Hassan el-Bushra, regional adviser for communicable diseases surveillance for the World Health Organisation, said the girl was believed to have been infected after coming into contact with sick and dead birds.

Egypt's state news agency MENA identified the girl as 17-year-old Nouri Nadi of Fayyoum province. Bushra said she had started showing symptoms of the illness in late January, but initial tests had indicated she had seasonal flu. Later tests were positive for the H5N1 virus.

Neither Bushra nor MENA said when the girl died, but both indicated the death was recent.

The new case brings to 20 the number of people known to have been infected with bird flu in Egypt, which has the largest known cluster of human bird flu cases outside Asia. Twelve people have died and eight others have recovered since the virus first surfaced in Egyptian poultry a year ago.

Most people infected in Egypt had been in contact with poultry kept at home. The outbreak initially caused panic across the country and did extensive damage to the poultry industry.

But the Egyptian government said last month that poultry production had recovered to 1.8 million birds a day, just short of the 2 million level produced before the outbreak.

http://www.alertnet.org/thenews/newsdesk/L05689221.htm


new quote added:

Bushra said it was too early to tell if Nadi had been infected with the mutated strain, which killed a factory worker and his teenage niece in Gharbia province in the Nile Delta.

Bushra said he was unsure whether Nadi had been treated with Tamiflu at all, since early tests for bird flu in the girl were negative.

[Theresa42]

This appears to be a new case that we haven't heard about before since we don't have anyone on our tracking list from Al Fayyum governorate that was admitted last week -- or anyone called Nora Nadi for that matter.

There were four unidentified females all from one family admitted to hospital in Al Fayyum on Jan 20th. If (if) Nora Nadi/Nouri Nadi was one of them, then there should be 3 other of her family members who at least were showing symptoms back on the 20th. Not certain at all that Nora is one of those four, though.

- Al Fayyum Governorate - [currently 8-9 sus cases]

Fayoum Sadr Balomraneh Hospital:
01/15 - Nora Saber Abdalmenji (23), died - from the city of Atessa/Atsa

01/15 - Hanan Ramadan Mohammed (20) - from the village of Sheikh Fadl [village of Vidimin Bsenors?]
01/15 - -?- Hanan Ramadan Mohammed's husband, Aweys

01/19 - Mostafa Kamal Ahmed (child)
01/19 - e-Shirin Azim from the village Albsioneh -- trans to Abbassia Chest Hospital, Cairo [counted in Cairo]

01/20 - Unidentified 8 - female [all from one family - family from Suhaj?]
01/20 - Unidentified 9 - female
01/20 - Unidentified 10 - female
01/20 - Unidentified 11 - female

http://www.flutrackers.com/forum/sho...4&postcount=24

Al Fayyum Governorate:
http://en.wikipedia.org/wiki/Al_Fayyum_Governorate

[Dutchy]

snip, age corrected:

The 17-year-old Egyptian victim was believed to have been infected after coming into contact with sick and dead birds, the WHO official said.

http://www.alertnet.org/thenews/newsdesk/N04375568.htm

[Dutchy]

Egyptian teenager dies of bird flu

CAIRO (AFP) - A teenage girl has become the fifth Egyptian to die of bird flu in six weeks, a health official has said, amid fears of a global surge in infections by the deadly virus.


Nour Nadi, a 17-year-old from the impoverished oasis province of Fayyum, 100 kilometres (60 miles) south of the capital, died Monday of the H5N1 strain of avian influenza.

The World Health Organisation's John Jabbour said Tuesday the girl died of the normal strain of the virus rather than a new drug-resistant variety.

Of the 20 people diagnosed with the virus since it was first detected in Egypt in 2006, eight have survived, but the mortality rate increased after the emergence of what the WHO said was a more virulent strain late last year.

"In the last case in Beni Sueif (province), it had turned back to the normal strain and we expect this one to be the same," said Jabbour about Nadi's death.

In January, the WHO announced that people had died of bird flu in the Nile Delta province of Gharbiya, north of Cairo, after the virus mutated into a strain resistant to the common Tamiflu treatment.

Subsequent tests in the same and other areas have not shown the presence of the drug-resistant strain.

"The Gharbiya strain has died off and we are back to the normal strain," Jabbour told AFP.

Nadi died not because her infection was drug-resistant, he added, but because she tried to hide her symptoms from discovery because of the growing stigma surrounding the disease.

"This is delaying treatment. Once delayed 48 hours after the onset of symptoms, the treatment is no longer effective," said Jabbour.

"It is becoming a social stigma," he added. "If they report their symptoms, all chickens are killed in the radius of a kilometre (more than half a mile). That's why they are hiding it."

All the cases reported in Egypt so far involve people working in close proximity to fowl, indicating that the virus is still only jumping from poultry to humans and has yet to take the feared next stage of transmission from human to human.

Egypt has launched a broad awareness campaign in a bid to swiftly isolate any outbreaks among domestic poultry and is working on vaccinating the vast numbers of backyard chickens across the country.

According to the WHO, a total of 165 people have now died from bird flu around the world. Experts fear the virus could cause a pandemic by mutating into a form that is transmissible between humans.

David Nabarro, who heads the United Nations' efforts to coordinate the fight against the disease, warned recently that a surge in outbreaks should be expected in the coming months.

With 12 deaths, Egypt is the fifth most affected country in the world and the worst-hit outside Asia.

http://news.yahoo.com/s/afp/20070206...NlYwMlJVRPUCUl

[HenryN]

Bird Flu Kills Egyptian Girl, Infects Two Indonesians (Update1)

By Karima Anjani and Dania Saadi
Feb. 6 (Bloomberg) -- Bird flu killed an Egyptian girl and infected two more people in Indonesia. The virus also reemerged in poultry in Russia and may have killed a woman in Azerbaijan.
The H5N1 strain of avian influenza has resurfaced in the U.K., Japan and at least seven other countries in Asia, Europe and Africa the past two months, increasing the risk of human infection and providing chances for the virus to mutate into a pandemic form.
In Indonesia, which has reported the most avian-flu deaths worldwide, the virus infected a man in his 30s and a 15-year-old girl, who may have gotten the virus from a wild bird, a health ministry official said today.
``She caught a wild bird near her home and it was reported the bird died two days later,'' said Joko Suyono, an official at the ministry's avian-flu information center. The girl was admitted to Jakarta's Persahabatan Hospital yesterday, five days after she developed flu-like symptoms, he said.
The H5N1 virus is known to have infected 271 people in 11 countries, killing 165 of them, since 2003, the World Health Organization estimates. The virus is a threat mainly to birds at the moment, though it may mutate and gain the ability to spread between people, experts say.
Indonesia, the world's fourth-most-populous country, has recorded 63 fatalities, 21 more than any other nation. The other patient confirmed today to have tested positive for the H5N1 virus was hospitalized in the city of Bandung in West Java province, Suyono said.
Pandemic Vaccines
The disease entered the U.K. earlier this week when turkeys died at a farm in Suffolk, prompting tighter security measures across Europe.
``The events in recent weeks, especially outbreaks in the U.K. and Hungary, call for even more vigilance,'' French Prime Minister Dominique de Villepin said in a statement today.
More than a dozen drug companies worldwide are using H5N1 as the basis for vaccines that would protect people from a pandemic sparked by the virus.
Indonesia wants vaccine makers to seek permission to use viruses collected there to secure access to the shots produced, said Triono Soendoro, director-general of the National Institute of Health Research and Development.
``What we want to avoid happening is being in a position of not being able to afford to buy the vaccines made from our own strain,'' Soendoro said in an interview today. If a pandemic occurs, ``we have to give shots to the poor and the government has to pay that cost. It will be a burden on our budget.''
Egyptian Case
The Indonesian government decided Dec. 20 to restrict access to its live H5N1 viruses after Melbourne-based CSL Ltd. began developing a vaccine based on material collected from an Indonesian patient. Indonesian officials now want companies to sign a so-called material transfer agreement before specimens are released, Soendoro said.
Egypt's health ministry said a 17-year-old girl who died Feb. 4 in the southern province of Fayoum, about 100 kilometers (62 miles) south of Cairo, was the country's 20th human H5N1 case and 12th fatality.
Health authorities weren't able to give her Roche Holding AG's Tamiflu antiviral medicine before she died, ministry spokeswoman Sayid Abbas said over the telephone today.
Tests in Russia
In Russia, the virus killed 45 domestic poultry on farms in Krasnodar territory, Itar-Tass said yesterday, citing Irina Voronkova, an adviser to the head of the regional consumer rights protection agency.
The H5N1 infections are the first in the southern territory this year, the report said. In 2006, more than 300,000 birds died of the virus on one poultry farm, it said.
Tests for the virus are being run on a 38-year-old woman from Azerbaijan's Neftchala region who died late yesterday, the Azeri-Press Information Agency said.
The woman died at the Scientific Institute of Lung Diseases after being hospitalized on Feb. 2 with pneumonia, the news agency reported on its Web site, citing Khayyam Amado, the institute's head physician.
A survey by state veterinary service officials on Feb. 3 found no mass poultry deaths suggestive of avian flu in the village where the woman lived, it said. Poultry samples were sent to the Republic Veterinary Laboratory for testing and results will be reported soon, the news agency said.
To contact the reporter on this story: Karima Anjani in Jakarta at kanjani@bloomberg.net ; Dania Saadi in Cairo at at dsaadi2@bloomberg.net
Last Updated: February 6, 2007 08:33 EST

http://www.bloomberg.com/apps/news?p...VJQ&refer=asia

[HenryN]

Commentary at

http://www.recombinomics.com/News/02...Wild_Bird.html

[Mellie]

Wild Bird Linkage with H5N1 Positive Case in Jakarta
Recombinomics Commentary
February 6, 2007

In Indonesia, which has reported the most avian-flu deaths worldwide, the virus infected a man in his 30s and a 15-year-old girl, who may have gotten the virus from a wild bird, a health ministry official said today.

``She caught a wild bird near her home and it was reported the bird died two days later,'' said Joko Suyono, an official at the ministry's avian-flu information center. The girl was admitted to Jakarta's Persahabatan Hospital yesterday, five days after she developed flu-like symptoms, he said.

The above comments provide a link between a confirmed H5N1 case (15F) in Jakarta with a wild bird. The girl lived in an upscale neighborhood in Jakarta, and the failure to link the case to domestic poultry is similar to the circumstances surrounding first H5N1 cluster in Tangerang, adjacent to Jakarta.

The initial case in July, 2005 involved H5N1 with a novel cleavage site, RESRRKKR. In all but one human isolate on Java, including sequences reported for this year, the same cleavage site has been reported. Attempts to link this novel cleavage site and associated changes in all 8 gene segments has had limited success.

Last fall 91 H5N1 positive poultry samples were sent to a WHO affiliated lab in Australia. Approximately 50 sequences were made public, and only three had the novel cleavage site. Two were from chickens on Sumatra. The only bird sample from Java was from a duck in Indramayu, isolated a year ago. However, this sequence was similar to a small subset of human cases. The vast majority of human isolates, include those from Indramayu, were distinct. Those sequences matched each other, as well as a cat sequence from Indramayu.

The failure to match the human sequences to additional bird isolates is likely linked to limited testing of other sources of H5N1. Recent media reports describe H5N1 sequences or antibodies in dogs and cats in Bali. H5N1 sequences from wild birds in Indonesia have not been reported.

Thus, although human H5N1 sequences have been reported in Indonesia since July, 2005, there have been no matches between a human isolate and a nearby bird isolate, although the death of nearby poultry is frequently cited in WHO updates on confirmed human cases.

The isolation and sequencing of H5N1 from wild birds in Indonesia would be useful.

[Dutchy]

Avian influenza - situation in Egypt - update 3

6 February 2007

The Egyptian Ministry of Health and Population has announced a new human case of avian influenza A(H5N1) virus infection.

The case was confirmed by the Egyptian Central Public Health Laboratory and by the US Naval Medical Research Unit No.3 (NAMRU-3).

The 17-year-old female from Fayyoum Governorate developed symptoms on 25 January 2007 and was initially treated for seasonal influenza.

She was hospitalized on 1 February with fever and breathing difficulties, and died on 2 February.

Initial investigations into the source of her exposure indicate the presence of sick and dead poultry at her home in the days prior to the onset of symptoms.

Of the 20 cases confirmed to date in Egypt, 12 have been fatal.

http://www.who.int/csr/don/2007_02_06/en/index.html

[Theresa42]

Google-translated from Arabic:

Noura, the first event of the death of avian influenza in Fayyoum
Feb 7, 2007

Fayoum Mr. Shora: For the first time in Fayyoum province, which is famous for rearing father envisage died and the first case of avian influenza governor e. The girl called Noura Club Mohamed Abbas 17 village M. the emergence of Abdullah away from the town of Fayoum kilometers metric N. The girl had been hit by severe cold popular inflammation thirst was taken to hospital pathogenesis of Fayoum was taken Ain e and sent to the labs were transferred to the central M. Scheve Urban Cairo but they died.

The girl was found that mixing of birds, yesterday, the committees of veterinary medicine, health and Supply Wa Police Fayyoum examined all the village citizens and the execution of Cem Regrettably birds on the roofs of houses and roads. Dr. Muhammad Sa'id, the director of Preventive Medicine Department Health that the girl appeared to symptoms of the disease in his case a backlog was transferred to Cairo, they died and e Settlements first human case of avian influenza this year.

The girl has three sisters, who were born and Petrbi e poultry, and a week ago were surprised that all the birds that they had been dead custody after the girl was sold satisfied with the disease.

Her father Club Falah Mohammed Abbas said: once infected with a rise in temperature, I introduced p my doctor recommended that the village and transported to the hospital and I transferred to the vaccines.

He denies her father severely infected with avian influenza and photography or refused to give a picture of the deceased girl.

This incident revealed negligence and laxity in the hospitals Chechen and shortcomings in the face of this disease and to preserve me o by any willingness to confront the disease avian influenza special e if we know that the organs of respiration industrial hospital general does not work and there is no such equipment in the hospital Hamia T.

http://www.alwafd.org/v2/News/NewsDe...df4de25b421b30

[Theresa42]

Originally Posted by Dutchy (post #6)

Bushra said she had started showing symptoms of the illness in late January, but initial tests had indicated she had seasonal flu.

The WHO says Nouri's symptoms started on Jan 25...

Originally Posted by Dutchy (post #13)

The 17-year-old female from Fayyoum Governorate developed symptoms on 25 January 2007 and was initially treated for seasonal influenza.

...but their dates have sometimes conflicted with other reported dates in the past. What if Nouri's symptoms actually developed earlier -- say around the 19th or 20th (that would still be 'late January', wouldn't it?)? Then she -- and her three sisters (see post #14) -- might, indeed, be the 4 unidentified female relatives reported as suspected case on Jan 20th:

4 suspected cases (all female) from one family in Al Fayyum (not sure if we've heard about these) ... 3 suspected cases in Banha, Al Qalyubiyah (have heard about these)....

Google-translated from Arabic:

Test WHO reveal turn [change] avian influenza ... And warnings of [possible future] transmission between humans
Jan 20, 2007

Tests proved by the regional office of the World Health Organization in Egypt, a turn of the first H5N1 causes avian influenza, where tests revealed the presence of five developments in the composition of the virus leading to drug resistance , which is the property only universally recognized to resist the virus.

Medical sources revealed that the worst case scenario and expected, lies in the fact that the modified virus to advanced stages, ending the transmission of person to person, not from bird to man, to become closer to the epidemic, noting that some estimates, expects to kill off the hardy Advanced avian influenza virus, the lives of tens of millions of inhabitants of the Middle East.

For its part, the Ministry of Health has taken all precautions and measures to counter the spread of the virus, following the announcement of the results of these tests yesterday evening, especially after the discovery of cases of positive birds infected with influenza among humans, the latest citizenship Warda Ahmed Eid occupying the village "Hlih Original Status", Beni Suef Governorate.

The director of the Department of Preventive Medicine Beni Suef, has been formed three committees to fortify the village of "Hlih" and the surrounding villages. He received hospital yesterday pathogenesis of Fayoum four women from one family, living with symptoms similar to avian influenza virus, also received hospital pathogenesis "of cows" [Banha] three cases.

http://www.07770500.com/News_Service...s.asp?id=12519

[Theresa42]

Nadi's mother also sick and in hospital in Cairo...

Egypt Teenage Girl Dies of Bird Flu
Jano Charbel & Agencies

CAIRO, 7 February 2007 — A teenage girl became the fifth Egyptian to die of bird flu in six weeks, a health official said yesterday, amid fears of a global surge in infections by the deadly virus. Nour Nadi, a 17-year-old from the impoverished oasis province of Fayyum, 100 kilometers south of the capital, died Monday of the H5N1 strain of avian influenza.

Nadi’s mother, Marzouqa Ramadan, who may have caught the virus from her daughter, was said to have been admitted to a respiratory illnesses hospital in the Al-Abbasiya district of Cairo, on the same day, where she is being examined by doctors.

The World Health Organization’s John Jabbour said the girl died of the normal strain of the virus rather than a new drug-resistant variety. Of the 20 people diagnosed with the virus since it was first detected in Egypt in 2006, eight have survived, but the mortality rate increased after the emergence of what the WHO said was a more virulent strain late last year.

“In the last case in Beni Sueif (province), it had turned back to the normal strain and we expect this one to be the same,” said Jabbour about Nadi’s death. In January, the WHO announced that people had died of bird flu in the Nile Delta province of Gharbiya, north of Cairo, after the virus mutated into a strain resistant to the common Tamiflu treatment.

Subsequent tests in the same and other areas have not shown the presence of the drug-resistant strain. “The Gharbiya strain has died off and we are back to the normal strain,” Jabbour told AFP. Nadi died not because her infection was drug-resistant, he added, but because she tried to hide her symptoms from discovery because of the growing stigma surrounding the disease.

In another development, Egyptian President Hosni Mubarak ordered members of the opposition Muslim Brotherhood, including the group’s number three, to stand trial before a military court, officials said yesterday.

“The president of the republic has ordered that leading Muslim Brotherhood member Khayrat Al-Shater and others be tried before a military court,” the source said, without specifying how many co-defendants faced trial.

Shater, the movement’s main financier, is part of a group of 29 Brotherhood members whose assets were frozen by the state last month on charges of money laundering and financing illegal activities. “It is a cruel decision and it is a political one,” the Brotherhood’s deputy supreme guide Mohammed Habib told AFP.

http://www.arabnews.com/?page=4&sect...d=7&m=2&y=2007

[Theresa42]

Report of Nadi's mother being hospitalized from the Egyptian government's bf website...

Google-translated from Arabic:

The death of the 12th contracted avian flu
Feb 6, 2007

The Ministry of Health announced yesterday 2-5-2007 for the death of Miss Nu OL Club [Nour Nadi] of Fayoum 17 years after his [her] illness will Aspatha Unza for birds.

This is a case of death No. 12 of the total 20 injured Bal since the disease appeared in the last year. [R]eceived a Hospital Abbasiya yesterday 2-5-2007 Ms. sisters, the father [mother] of Ramadan [Marzouqa Ramadan] e deceased girl on suspicion of the disease infected Otj Ri procedures required analysis.

http://birdflu.sis.gov.eg/ahtml/aflu0566.htm

[HenryN]

Commentary at

http://www.recombinomics.com/News/02..._6_Mother.html

[Sally Furniss]

Mother of Sixth Qinghai H5N1 Fatality in Egypt is Hospitalized
Recombinomics Commentary
February 7, 2007

A teenage girl became the fifth Egyptian to die of bird flu in six weeks, a health official said yesterday, amid fears of a global surge in infections by the deadly virus. Nour Nadi, a 17-year-old from the impoverished oasis province of Fayyum, 100 kilometers south of the capital, died Monday of the H5N1 strain of avian influenza.

Nadi’s mother, Marzouqa Ramadan, who may have caught the virus from her daughter, was said to have been admitted to a respiratory illnesses hospital in the Al-Abbasiya district of Cairo, on the same day, where she is being examined by doctors.

The above translation describes the hospitalization of the mother of the most recent confirmed H5N1 case in Egypt. The recent case (17F) was the sixth fatal case this season in Egypt. If the mother is positive for H5N1, then five of the seven cases in Egypt will be from clusters. Sequences of H5N1 from the first three cases have M230I, which is also likely in the third Gharbiya cluster member. This change, which is adjacent to the receptor binding domain, is also in seasonal flu (H1N1, H3N2, influenza B). It has also been found in H5N1 from birds in Egypt, although it is encoded with sequences found in H5N1 as well as H7N3.

More information on the sequences of the recent confirmed cases as well as testing of her hospitalized mother would be useful.

[Theresa42]

Nadi's mother, father(?) and sisters reportedly test neg. Hat-tip, UK-Bird!

Google-translated from Arabic:

[Headline not available]
Feb 7, 2007

Cairo-MENA-Dr Abdel Rahman Shahin hurt event official spokesman of the Ministry of Health. The results of the analysis of the girl's mother, "Nuri Club," died Monday in Fayyoum result of presence of avian flu was negative.
The spokesman - in response to rumors about the injury the girl's mother Nouri, or a member of her family Banfelonz a bird "that the results of the analysis of his father [mother?], the girl negative, in addition to the results of the analysis of all Almkhalten girls also negative."

It is noteworthy that Nouri Club is the case of the 12 died avian influenza coordinates of the total 20 cases of human hit since the disease appeared in Egypt last March, but so far between what has been recovered from all the other eight cases.

http://www.masrawy.com [Permalink to article unfortunately not available.]

[wetDirt]

Originally Posted by Mellie

Wild Bird Linkage with H5N1 Positive Case in Jakarta
Recombinomics Commentary
February 6, 2007

[color=#000000]In Indonesia, which has reported the most avian-flu deaths worldwide, the virus infected a man in his 30s and a 15-year-old girl, who may have gotten the virus from a wild bird, a health ministry official said today.

``She caught a wild bird near her home and it was reported the bird died two days later,'' said Joko Suyono, an official at the ministry's avian-flu information center. The girl was admitted to Jakarta's Persahabatan Hospital yesterday, five days after she developed flu-like symptoms, he said.

The above comments provide a link between a confirmed H5N1 case (15F) in Jakarta with a wild bird. The girl lived in an upscale neighborhood in Jakarta, and the failure to link the case to domestic poultry is similar to the circumstances surrounding first H5N1 cluster in Tangerang, adjacent to Jakarta.

snip...

COLOR]

This and the Egyptian girl who also claimed infection by wild bird don't sound quite right. In both cases, the consequence of mentioning a poultry source causes all the poultry/kept birds in the area to be slaughtered, and attaches a social stigma. I'd rather just compare sequences, and not pay much attention to what people claim as a source of infection. There are too many reasons people may mistake or misstate the source. Let the data decide.

[Theresa42]

Egyptian authorities weren't able to detect H5N1 from Nadi's samples? It was NAMRU that confirmed her?

Google-translated from Arabic:

Three stories of the death of the victim No. 12 of avian flu
Feb 7, 2007
Wrote Tariq Amin and meet Bakri Mohamed Farghali

With the formal announcement of the death of the victim No. 12 Banfelonz a bird in the province of Fayoum, It Nora Club <17 years>, There were several accounts of the cause of death.

Dr. Hussein Abutalb Sophie, Undersecretary of the Ministry of Health in Fayyoum, l : Different sampling results from the girl suffered the death of confirming .

He pointed to inconsistencies Abutalb which happened in the case between the results of laboratory tests conducted by the Center Yeh to the Ministry of Health for the disease, and the results of the sample sent to the laboratory of [NAMRU] group of the American navy, He said that the results of the analysis of the negative health factor, While the results of the analysis [NAMRU] positive pressed him.

In the official version again, Dr. Amr Qandil, head of the Central Administration did not Fights infection in the Ministry of Health: that died four days ago [i.e. Feb 2], two days before the formal announcement of her death as a result deciding H5N1 avian influenza, in accordance with the assurances by the Ministry of Health and World Health Organization e.

The Qandil told that Nora underwent treatment in one of the private clinics in Fayoum, pointing out that the doctor as a condition on Aat Parr did not disclose to the doctor for Mkhalttha birds.

And turn around and the different symptoms of the virus than ever before, Ahmed al-Hadidi, professor of chest diseases at Cairo University, that the symptoms did not differ, He pointed out that the problem is to resist the virus Ela Qar [in Nadi??]. He explained that the symptoms are new pneumonia pain Zdoj, and the water on the lung, and brain inflammation, in addition to the eye and throat inflammation and asthma.

http://www.almasry-alyoum.com/articl...leID=47256&r=t

[Theresa42]

Originally Posted by Theresa42

Egyptian authorities weren't able to detect H5N1 from Nadi's samples? It was NAMRU that confirmed her?

Google-translated from Arabic:

Three stories of the death of the victim No. 12 of avian flu
Feb 7, 2007
Wrote Tariq Amin and meet Bakri Mohamed Farghali

With the formal announcement of the death of the victim No. 12 Banfelonz a bird in the province of Fayoum, It Nora Club <17 years>, There were several accounts of the cause of death.

Dr. Hussein Abutalb Sophie, Undersecretary of the Ministry of Health in Fayyoum, l : Different sampling results from the girl suffered the death of confirming .

He pointed to inconsistencies Abutalb which happened in the case between the results of laboratory tests conducted by the Center Yeh to the Ministry of Health for the disease, and the results of the sample sent to the laboratory of [NAMRU] group of the American navy, He said that the results of the analysis of the negative health factor, While the results of the analysis [NAMRU] positive pressed him.

In the official version again, Dr. Amr Qandil, head of the Central Administration did not Fights infection in the Ministry of Health: that died four days ago [i.e. Feb 2], two days before the formal announcement of her death as a result deciding H5N1 avian influenza, in accordance with the assurances by the Ministry of Health and World Health Organization e.

The Qandil told that Nora underwent treatment in one of the private clinics in Fayoum, pointing out that the doctor as a condition on Aat Parr did not disclose to the doctor for Mkhalttha birds.

And turn around and the different symptoms of the virus than ever before, Ahmed al-Hadidi, professor of chest diseases at Cairo University, that the symptoms did not differ, He pointed out that the problem is to resist the virus Ela Qar [in Nadi??]. He explained that the symptoms are new pneumonia pain Zdoj, and the water on the lung, and brain inflammation, in addition to the eye and throat inflammation and asthma.

http://www.almasry-alyoum.com/articl...leID=47256&r=t

Another translation...

Three narrations of the victim's death of a number 12 to the bird flu
Feb 7, 2007

With the declaration officially about the victim's death of a number 12 by the bird flu in Al Fayum Governate, and she "a light a club" [Nouri Nadi] 17 a year, several novels [stories] appeared to the death reasons.

Doctor Hussein Sophie Aboutalb, the Ministry of Health deputy in Al Fayyum, said to "The Egyptian Today": that the difference of the results of the taken samples from the dead girl "a change to the virus" confirms an occurrence.

And Abu Taleb pointed to the conflict that happened in a condition "a light" [Nouri] between the analyses results that the central laboratories held to the Ministry of Health to its disease, and between the sample results sent to the laboratory of "Namro" belonging to the American navy, and it said that the health laboratories analyses results came a passivity [negative], while analyses results confirmed "Namro" the positivity of condition.

And in another official novel [story], doctor Amr Qandil the central department president for Al Adawi's fighting in the Ministry of Health said: "A light" [Nouri] was dead before 4 days, any before two days of the declaration officially about its death due to their injury by the bird flu virus, according to the confirmations of Ministry of Health and World Health Organization.

And Qandil confirmed to "The Egyptian Today" that a light [Nouri] was submitted to the treatment in one of the special clinics in Al Fayyum, explaining that the doctor is its condition person that it is "a typhoid" [i.e. they diagnosed her as having typhoid] considering that it did not reveal to the doctor its mixing the birds.

And around the change of virus and the difference of its symptoms about a before, confirmed doctor Ahmed Al Hadidi the professor of the chest diseases in the Cairo University, the symptoms did not differ, pointing out that the problem became in the resistance of virus to the drug of "Al Tamiflou". And he explained that the new [?] symptoms are the double pneumonia, and waters on the lung, and an inflammation in the brain, to the side of ophthalmia and throat and the dyspnea.

[Theresa42]

Hat-tip, highflyer!

An update of the confirmed human cases of avian influenza A (H5N1) in Egypt
8 February 2007

Case Number: 20
Age: 17 years
Sex: female
Governorate: Fayoum

Exposure: the woman was exposed to infected and dead backyard birds (Chickens and ducks) several days before onset of symptoms. 150 birds died in that house. Some were slaughtered. Currently there are no birds in the house.

Clinical history: the patient developed the symptoms on 25 January 2007 and was initially treated for seasonal influenza. She was hospitalized in Fayyoum fever hospital on the 1st of February 2007 with fever and difficulty in Breathing.

Laboratory: Two throat swabs and one blood specimen were taken on the 2nd of February 2007 and sent to the Central Public Health Laboratories and NAMRU-3 for testing. The results were positive for H5N1. Genomic characterization of the virus is in process in the laboratories of Centers for Disease Control, CDC, in Atlanta.

Treatment: the patient was treated with Tamiflu and Adamine and interrupted oxygen.

Referral: On February 2, 4:00 pm, the patient was referred to Abbasiya chest hospital in Cairo but because of her critical condition they stopped at the Omraniyya chest hospital where she died.

Of the 20 cases confirmed to date in Egypt, 12 have been fatal.

http://www.emro.who.int/ [<< prolly not a permalink]

[HenryN]

Originally Posted by Theresa42

Hat-tip, highflyer!

An update of the confirmed human cases of avian influenza A (H5N1) in Egypt
8 February 2007

Case Number: 20
Age: 17 years
Sex: female
Governorate: Fayoum

Exposure: the woman was exposed to infected and dead backyard birds (Chickens and ducks) several days before onset of symptoms. 150 birds died in that house. Some were slaughtered. Currently there are no birds in the house.

Clinical history: the patient developed the symptoms on 25 January 2007 and was initially treated for seasonal influenza. She was hospitalized in Fayyoum fever hospital on the 1st of February 2007 with fever and difficulty in Breathing.

Laboratory: Two throat swabs and one blood specimen were taken on the 2nd of February 2007 and sent to the Central Public Health Laboratories and NAMRU-3 for testing. The results were positive for H5N1. Genomic characterization of the virus is in process in the laboratories of Centers for Disease Control, CDC, in Atlanta.

Treatment: the patient was treated with Tamiflu and Adamine and interrupted oxygen.

Referral: On February 2, 4:00 pm, the patient was referred to Abbasiya chest hospital in Cairo but because of her critical condition they stopped at the Omraniyya chest hospital where she died.

Of the 20 cases confirmed to date in Egypt, 12 have been fatal.

http://www.emro.who.int/ [<< prolly not a permalink]

Sequence is similar to Beni Suef, but also has S227N.

[Theresa42]

Originally Posted by niman

Sequence is similar to Beni Suef, but also has S227N.

Beni Suef (aka Bani Suwayf) and Al Fayyum (Fayoum) are neighboring governorates:

Bani Suwayf Governorate:
http://en.wikipedia.org/wiki/Bani_Suwayf_Governorate

Al Fayyum Governorate:
http://en.wikipedia.org/wiki/Al_Fayyum_Governorate

[Theresa42]

Originally Posted by Theresa42

Beni Suef (aka Bani Suwayf) and Al Fayyum (Fayoum) are neighboring governorates:

Bani Suwayf Governorate:
http://en.wikipedia.org/wiki/Bani_Suwayf_Governorate

Al Fayyum Governorate:
http://en.wikipedia.org/wiki/Al_Fayyum_Governorate

Warda Eid Ahmed, the case from Bani Suwayf, was from (I think) near Hillyah in Bani Suwayf governorate [source].

Nouri Nadi, the case from Al Fayyum governorate, was from Al Fayyum city [source].

These are ca. 30 miles away from each other (as the crow flies) -- (map of Hillyah).

[HenryN]

Commentary at

http://www.recombinomics.com/News/02...227N_2007.html

[AlaskaDenise]

Originally Posted by niman

Commentary at

http://www.recombinomics.com/News/02...227N_2007.html

Commentary

S227N Re-emerges in Qinghai H5N1 in Egypt
Recombinomics Commentary
February 9, 2007

NAMRU-3 has generated HA and NA sequences from H5N1 from the recent confirmed case in Fayyoum. These sequences are very similar to the HA and NA sequences from A/Egypt/0636-NAMRU3/2007 from the patient in nearby Beni Suef. Like the earlier HA sequence, there is a 3 BP deletion in the recent isolate.

However, the HA sequence was a mixture that included S227N, which is linked to increased affinity for human receptors.

S227N was first reported in both isolates from a family in Hong Kong who had gone to Fujian province for a visit in early 2003. The daughter died in China with bird flu symptoms and H5N1 was isolated from the father and son in Hong Kong. The father died, but both isolates (on MDCK cells from dog kidney) had S227N. A screening of H5N1 isolates in a receptor binding assay identified these two isolates as having increased affinity for 2,6 gal and decreased affinity for 2,3 gal.

Donor sequences for the acquisition of S227N in Qinghai H5N1 were present in H9N2 isolate that were almost exclusively in the Middle East. A warning was issued October 22, 2005 before Qinghai H5N1 had been confirmed in any human. S227N was then found in the index case for Turkey in early 2006. However, it was not in the isolate from his sister. Two additional sequences have been released, and S227N was in one of the two. Thus, S227N was in two of the four HA sequences from patients in Turkey, but in only one of the two siblings.

S227N was also in an human isolate from Egypt last year and S227N was found in an additional patient in Vietnam. However, the published data from a patient in Vietnam showed that S227N was in only one of three clones from that patient (all isolated with MDCK cells), indicating that patients with S227N had mixtures, and detecting S227N was most easily accomplished by looking at multiples clones from the same patient.

The latest sequence also is a mixture at the position encoding S227N. One sequence is wild type (with an A) while the other codes for S227N (with a G).

Although recent papers indicate H5N1 can be found in the upper respiratory tract, even when the binding preference is 2,3, sequences with a 2,6 preference lead to more sneezing (in ferrets described in Science), providing a mechanism for easier transmission. Thus, samples with S227N are more likely to lead to larger human clusters

S227N in Qinghai isolates from two patients in Turkey as well as two patients in Egypt indicates this receptor binding domain change is a major concern for the region.


.

[HenryN]

An update of the confirmed human cases of avian influenza A (H5N1) in Egypt
8 February 2007

Case Number: 20
Age: 17 years
Sex: female
Governorate: Fayoum
Exposure: the woman was exposed to infected and dead backyard birds (Chickens and ducks) several days before onset of symptoms. 150 birds died in that house. Some were slaughtered. Currently there are no birds in the house.
Clinical history: the patient developed the symptoms on 25 January 2007 and was initially treated for seasonal influenza. She was hospitalized in Fayyoum fever hospital on the 1st of February 2007with fever and difficulty in Breathing.
Laboratory: Two throat swabs and one blood specimen were taken on the 2nd of February 2007 and sent to the Central Public Health Laboratories and NAMRU-3 for testing. The results were positive for H5N1. Genomic characterization of the virus is in process in the laboratories of Centers for Disease Control, CDC, in Atlanta.
Treatment: the patient was treated with Tamiflu and Adamine and interrupted oxygen.
Referral: On February 2, 4:00 pm, the patient was referred to Abbasiya chest hospital in Cairo but because of her critical condition they stopped at the Omraniyya chest hospital where she died.
Of the 20 cases confirmed to date in Egypt, 12 have been fatal.

http://www.emro.who.int/