September 22nd, 2011, 06:25 PM
Join Date: Dec 2009
Revista Science - Aceleramiento del surgimiento de resistencia a antibioticos bacterianos en microambientes conectados
Resumen - Traduccion electronica editada
La aparición de resistencia bacteriana a los antibióticos es un problema creciente, sin embargo, las variables que influyen en la tasa de aparición de resistencia no se conocen bien. En un dispositivo de microfluidos diseñado para imitar la forma natural los nichos de bacterias, la resistencia de Escherichia coli a los antibióticos ciprofloxacina se desarrollo en 10 horas. La resistencia surgió con tan sólo 100 bacterias en la inoculación inicial. Secuenciación del genoma completo de los organismos resistentes reveló que cuatro polimorfismos funcionales de nucleótido único alcanzaron la fijación. El conocimiento sobre la rápida aparición de resistencia a los antibióticos en las condiciones heterogéneas en el cuerpo de los mamíferos puede ser útil en la comprensión de la aparición de resistencia a los medicamentos en la quimioterapia del cáncer.
Science 23 September 2011:
Vol. 333 no. 6050 pp. 1764-1767
Acceleration of Emergence of Bacterial Antibiotic Resistance in Connected Microenvironments
- Qiucen Zhang1,
- Guillaume Lambert1,
- David Liao2,
- Hyunsung Kim3,
- Kristelle Robin4,
- Chih-kuan Tung5,
- Nader Pourmand3,
- Robert H. Austin1,4,*
- 1Department of Physics, Princeton University, Princeton, NJ 08544, USA.
- 2Department of Pathology, University of California, San Francisco, CA 94143, USA.
- 3University of California, Santa Cruz Genome Sequencing Center, University of California, Santa Cruz, CA 95064, USA.
- 4Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong.
- 5Department of Physics, University of Pittsburgh, Pittsburgh, PA 15260, USA.
- ↵*To whom correspondence should be addressed. E-mail: firstname.lastname@example.org
The emergence of bacterial antibiotic resistance is a growing problem, yet the variables that influence the rate of emergence of resistance are not well understood. In a microfluidic device designed to mimic naturally occurring bacterial niches, resistance of Escherichia coli
to the antibiotic ciprofloxacin developed within 10 hours. Resistance emerged with as few as 100 bacteria in the initial inoculation. Whole-genome sequencing of the resistant organisms revealed that four functional single-nucleotide polymorphisms attained fixation. Knowledge about the rapid emergence of antibiotic resistance in the heterogeneous conditions within the mammalian body may be helpful in understanding the emergence of drug resistance during cancer chemotherapy.
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