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J Virol. Seasonal Trivalent Inactivated Influenza Vaccine Does Not Protect Against Newly Emerging Variants of Influenza A (H3N2v) virus in Ferrets.
[Source: US National Library of Medicine, full text: (LINK). Abstract, edited.]
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J Virol. 2012 Oct 31. [Epub ahead of print]
Seasonal Trivalent Inactivated Influenza Vaccine Does Not Protect Against Newly Emerging Variants of Influenza A (H3N2v) virus in Ferrets.
Houser KV, Katz JM, Tumpey TM.
Source: Influenza Division, National Center for Immunization and Respiratory Diseases, Center for Disease Control and Prevention, Atlanta, GA 30333.
Abstract
The recent increase in human cases with influenza A H3N2 variant virus [A(H3N2)v] highlights the need to assess whether seasonal influenza vaccination provides cross-protection against A(H3N2)v virus. Our data demonstrate that the 2011-2012 trivalent inactivated influenza vaccine (TIV) protected ferrets against homologous H3N2 virus challenge, but provided minimal to no protection against A(H3N2)v virus. The complete absence of specific hemagglutination-inhibition antibody response to A(H3N2)v is consistent with the poor cross-protection observed among TIV-immune animals.
PMID: 23115290 [PubMed - as supplied by publisher]
-Seasonal Trivalent Inactivated Influenza Vaccine Does Not Protect Against Newly Emerging Variants of Influenza A (H3N2v) virus in Ferrets.
Houser KV, Katz JM, Tumpey TM.
Source: Influenza Division, National Center for Immunization and Respiratory Diseases, Center for Disease Control and Prevention, Atlanta, GA 30333.
Abstract
The recent increase in human cases with influenza A H3N2 variant virus [A(H3N2)v] highlights the need to assess whether seasonal influenza vaccination provides cross-protection against A(H3N2)v virus. Our data demonstrate that the 2011-2012 trivalent inactivated influenza vaccine (TIV) protected ferrets against homologous H3N2 virus challenge, but provided minimal to no protection against A(H3N2)v virus. The complete absence of specific hemagglutination-inhibition antibody response to A(H3N2)v is consistent with the poor cross-protection observed among TIV-immune animals.
PMID: 23115290 [PubMed - as supplied by publisher]
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