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Mutation Altering Stability of Surface Molecule in Acid Enables H5N1 Infection of Mammals
Mutation Altering Stability of Surface Molecule in Acid Enables H5N1 Infection of Mammals
Feb. 28, 2013 ? A single mutation in the H5N1 avian influenza virus that affects the pH at which the hemagglutinin surface protein is activated simultaneously reduces its capacity to infect ducks and enhances its capacity to grow in mice according to research published ahead of print today in the Journal of Virology.
A single mutation in the H5N1 avian influenza virus that affects the pH at which the hemagglutinin surface protein is activated simultaneously reduces its capacity to infect ducks and enhances its capacity to grow in mice, according to researchers.
A study today - authored by Hassan Zaraket, Olga A. Bridges, Charles J. Russell - links a single mutation (lysine-to-isoleucine at position 58 in the H5N1 HA2 subunit) to increased replication in mice.
And not by just a little . . . by a hundred fold or better.
The study, which is scheduled to be formally published in the May issue of the Journal of Virology , can be accessed at the following link:
The pH of Activation of the Hemagglutinin Protein Regulates H5N1 Influenza Virus Replication and Pathogenesis in Mice
Hassan Zaraket, Olga A. Bridges, Charles J. Russell5
Department of Infectious Diseases, St. Jude Children's Research Hospital
Department of Microbiology, Immunology & 8 Biochemistry, College of Medicine, The University of Tennessee Health Science Center http://www.asm.org/images/Comm...
Comment: I wonder if this might also mean that virus shed in an acidic environment could be more prone to acquire this mutation, and speed an adaptation to mammals? I am mindful of the extreme levels of pollution (potentially giving rise to acid rain) in some endemic areas see China - Beijing pollution "more dangerous than SARS"
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