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Antimicrob Agents Chemother. Comparison of Oseltamivir and Oseltamivir Carboxylate Concentrations in Venous Plasma, Venous Blood, and Capillary Blood in Healthy Volunteers
[Source: Antimicrobial Agents and Chemotherapy, full text: (LINK). Abstract, edited.]
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Comparison of Oseltamivir and Oseltamivir Carboxylate Concentrations in Venous Plasma, Venous Blood, and Capillary Blood in Healthy Volunteers
Insti Instiaty<SUP>a</SUP>,<SUP>b</SUP>, Niklas Lindegardh<SUP>b</SUP>,<SUP>c</SUP><SUP>?</SUP>, Podjanee Jittmala<SUP>b</SUP>, Warunee Hanpithakpong<SUP>b</SUP>, Daniel Blessborn<SUP>b</SUP>,<SUP>c</SUP>, Sasithon Pukrittayakamee<SUP>a</SUP>, Nicholas J. White<SUP>b</SUP>,<SUP>c</SUP> and Joel Tarning<SUP>b</SUP>,<SUP>c</SUP>
<SUP></SUP>
Author Affiliations: Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand<SUP>a </SUP>Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand<SUP>b </SUP>Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom<SUP>c</SUP>
<SUP></SUP>
ABSTRACT
Oseltamivir and oseltamivir carboxylate concentrations were measured in venous plasma, venous blood, and capillary blood taken simultaneously from 24 healthy volunteers. Median (range) venous-blood-to-plasma ratios were 1.42 (0.920 to 1.97) for oseltamivir and 0.673 (0.564 to 0.814) for oseltamivir carboxylate. Capillary blood/venous plasma ratios were 1.32 (0.737 to 3.16) for oseltamivir and 0.685 (0.502 to 1.34) for oseltamivir carboxylate. Oseltamivir concentrations in venous and capillary blood were similar. Oseltamivir carboxylate showed a time-dependent distribution between venous and capillary blood.
FOOTNOTES
Received 5 December 2012. Returned for modification 22 January 2013. Accepted 12 March 2013.
Address correspondence to Joel Tarning, joel@tropmedres.ac.
? Deceased.
Published ahead of print 18 March 2013
Copyright ? 2013, American Society for Microbiology. All Rights Reserved.
The authors have paid a fee to allow immediate free access to this article.
-Insti Instiaty<SUP>a</SUP>,<SUP>b</SUP>, Niklas Lindegardh<SUP>b</SUP>,<SUP>c</SUP><SUP>?</SUP>, Podjanee Jittmala<SUP>b</SUP>, Warunee Hanpithakpong<SUP>b</SUP>, Daniel Blessborn<SUP>b</SUP>,<SUP>c</SUP>, Sasithon Pukrittayakamee<SUP>a</SUP>, Nicholas J. White<SUP>b</SUP>,<SUP>c</SUP> and Joel Tarning<SUP>b</SUP>,<SUP>c</SUP>
<SUP></SUP>
Author Affiliations: Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand<SUP>a </SUP>Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand<SUP>b </SUP>Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom<SUP>c</SUP>
<SUP></SUP>
ABSTRACT
Oseltamivir and oseltamivir carboxylate concentrations were measured in venous plasma, venous blood, and capillary blood taken simultaneously from 24 healthy volunteers. Median (range) venous-blood-to-plasma ratios were 1.42 (0.920 to 1.97) for oseltamivir and 0.673 (0.564 to 0.814) for oseltamivir carboxylate. Capillary blood/venous plasma ratios were 1.32 (0.737 to 3.16) for oseltamivir and 0.685 (0.502 to 1.34) for oseltamivir carboxylate. Oseltamivir concentrations in venous and capillary blood were similar. Oseltamivir carboxylate showed a time-dependent distribution between venous and capillary blood.
FOOTNOTES
Received 5 December 2012. Returned for modification 22 January 2013. Accepted 12 March 2013.
Address correspondence to Joel Tarning, joel@tropmedres.ac.
? Deceased.
Published ahead of print 18 March 2013
Copyright ? 2013, American Society for Microbiology. All Rights Reserved.
The authors have paid a fee to allow immediate free access to this article.
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