Indonesia HUMAN Cases - Mar/2/2008 - Mar/21/2008

[Commonground]

Re: Indonesia HUMAN Cases - Feb 4, 2007+

RSHS Rawat Suspect Flu Burung Ke-112
08/03/2008

Isolasi Flamboyan Rumah Sakit Hasan Sadikin space (RSHS) Bandung again treated the patient suspect bird flu to 112.
The patient had the initials AS (42), the resident Kp.
Nyingkir RT 02/RW 15 villages Cigugur Glad, Kec.
Parongpong, Kab.
Bandung was Barat (KBB) this began to be treated in Flamboyan RSHS Space since Wednesday (5/3).

According to the team of the handling doctor of RSHS bird flu, AS experienced the sign resembled bird flu.
Moreover, the AS patient also admitted to having contact with the chicken that died suddenly in his residence environment.
From the report on the patient on the daily suspect Flamboyan RSHS Space bird flu, was learnt AS was reconciliation from the Ciwaruga Community Health Centre.
Like that arrived in RSHS, AS was at once observed and known positive experienced the cough, breathless, as well as body heat achieved 38 Celsius levels.
The patient's blood pressure was not better namely 106/64 mmHg, but results thorax the photograph of the team of the doctor did not find the existence bronchopneumoni.

After being treated in Flamboyan Space, the patient was immediately given by Tamiflu a day twice with the dose very much drank 75 milligram.
The AS patient has also been taken the sample apus the nose and the throat as well as serology, to afterwards be checked further in the Penelitian Dan Pengembangan Kesehatan Hall (Balitbangkes) in Jakarta.

Was based on the wife's AS information, Oom Nurhasanah (25), five days before his husband experienced the high fever, there were approximately 11 chickens in his village that died suddenly.
In the meantime, one of the team's members of the handling doctor suspect RSHS bird flu, Dr. Primal Sudjana said, till Friday (7/3), the condition for the patient began to improve.

http://www.klik-galamedia.com/20080308/kolomlengkap.php?kolomkode=20080308052741

[Gert van der Hoek]

Re: Indonesia HUMAN Cases - Feb 4, 2007+

From Sulawesi

Condition suspected bird flu in Makassar improves

Metrotvnews.com, Makassar: Ririn, the child 12 years, suspect the bird flu inhabitant Makassar, South Sulawesi up to now still is treated in the Daerah Wahidin Sudirohusodo Public Hospital, Makassar, South Sulawesi.

He was picked up by the Penangulangan Flu Burung Rumah Sakit Wahidin Sudirohusodo Makassar Team, following the discovery of dozens of chickens that died suddenly in his house that was in the Association complex Doctor Indonesia, Antang, Makassar, South Sulawesi.

Currently, he was treated in the room Ii, Gedung Perawatan Interna Pakis that was the room of the special isolation suspect bird flu.

After being treated by the Ririn condition gradually improved.
In fact beforehand he could experience the sign that resembled bird flu like the high fever, the cough pilek and breathless.

The team of the doctor who examined him stated him the bird flu negative.
However to ascertain him, the official continued to send the sample of his blood to Jakarta.

In the meantime, the Service of Kesehatan South Sulawesi has confirmed the cause of the death of the chicken around casualties's house was positive resulting from the bird flu virus.

http://www.metrotvnews.com/berita.asp?id=54949

[Gert van der Hoek]

Re: Indonesia HUMAN Cases - Feb 4, 2007+

Ririn, 12 yo from Makassar, Sulawesi tested negative for bird flu

http://www.fajar.co.id/news.php?newsid=57836

[Commonground]

Re: Indonesia HUMAN Cases - Feb 4, 2007+

Post #158

Ririn, 12, the resident of the IDI Antang Complex was stated by the negative suffered bird flu.
This assurance, was received after Ririn underwent the intensive inspection in RS Wahidin Sudirohusodo, on Friday, March 7, the morning.
"Setelah received the news had the poultry died that was accompanied by the person was sick, we at once descended to the field.
In this housing, our official brought Ririn to Wahidin that beforehand it was reported suffered bird flu," clear Kadis Kesehatan Makassar, Naisyah, on Friday, March 7.
Naisyah added, the Ririn inspection was carried out in Wahidin, because this hospital had facilities for the inspection and the maintenance of the bird flu sufferer.
After underwent rapid test, Ririn was stated by the negative.
Kadis added, information that mentioned had four people who were sick untrue.
The official who descended to the field found three other people has been healthy and carried out his activity as usual.

[Gert van der Hoek]

Re: Indonesia HUMAN Cases - Feb 4, 2007+

Father and son in Solo Hospital (Java) tested negative for bird flu:


Two patients suspect the resident's bird flu Kedungampel Kulon RT 1/8, Cawas, of Klaten had finally been permitted to come home from RSUD Dr Moewardi, on Friday (7/3/2008).

The two patients were stated by the bird flu negative.

The two patients were their respective Sudarmaji (37), and his child of Ibnu Fajar Hidayat (9).

Results of the laboratory of Litbangkes Department of Health said, the two residents who beforehand were sentenced suspect bird flu evidently the bird flu negative.

More:

http://news.okezone.com/index.php/ReadStory/2008/03/07/1/89848/negatif-flu-burung-ayah-anak-di-klaten-pulang

[Oracle]

Re: Indonesia HUMAN Cases - Feb 4, 2007+

Noted the comment on blood test fallability.

I would like to advance an alternative explanation

I think we have a new, virulent strain of New Castle disease emerging in particular areas of Indonesia. NDV is known to cause disease in humans, usually from direct aerosol contact (in lab, by veterinarians or handling of infected poultry).

In the cases where families clusters (parent, offspring) were treated with tamiflu, and where disease rapidly progressed to a point requiring ventilllators, survival is usually dismal. Yet here, we have within the last few weeks, several clusters where these patients survived and were discharged. In some cases, bird deaths were reported, but H5N1 in home or nearby poultry was not confirmed.

Perhaps it's time for WHO and the CDC to take a close look at the NDV strains in these Indonesian human H5N1- cases, where bird deaths were investigated, and reported to be infected with NDV, rather than HPAI.

It would be a rather interesting development.

[sharon sanders]

Re: Indonesia HUMAN Cases - Mar/2/2008+

NDV in Humans Info -


"..Clinical Disease in Humans

Humans are among the many species that can be infected with NDV in addition to at least 241 avian species.^1,50 The most common sign of infection of humans is conjunctivitis that develops within 24 hours of NDV exposure to the eye. In the first reported case, it was also noted that the preauricular lymph node on the involved side was swollen and tender. General symptoms of headache, discomfort, and slight chills occurred within 48 hours of the initial infection, but lasted for only 24 hours. Local treatment was used to relieve symptoms of the conjunctivitis, which cleared completely within a week. Virus was reisolated from the lacrimal fluids of the infected individual, who became seropositive within 2 weeks after the exposure. ⁴⁷ Subsequently, reported infections were similar and usually resulted in self-limiting eye infections characterized by unilateral to occasionally bilateral conjunctivitis, edema of the eyelids, congestion of the conjunctiva, tearing, and pain without involvement of the cornea. Rarely, NDV infection has resulted in symptoms of fever, chills, headache, pharyngitis, depressed appetite, photophobia, and general apathy.^50,51 A history of aerosol exposure was associated with most of the individuals who developed a generalized infection.⁵²
Many of the documented cases involved infections in laboratory workers who accidentally splashed hightiter NDV-infected egg fluids into their eyes, veterinary laboratory diagnosticians who performed postmortem examinations on infected birds or handled infectious tissues, workers in poultry processing plants, and poultry vaccination crews.^1,52 The absence of many recent reports suggests that such infections may be commonplace and that when they occur, they are mild and self-limiting.¹ The use of personal protective equipment and biological safety cabinets in laboratories has undoubtedly reduced the exposure of current laboratory workers.
The virulence of NDV isolates does not appear to differ for humans in contrast to the wide difference in virulence for chickens. Experimentation with a virulent field isolate was the cause of the initial human infection, but similar signs can result from infections with low virulence NDV strains, such as B₁, which are commonly used as ND vaccines.⁵³ No evidence exists to support human-to-human transmission,^1,51 but the potential for human-to-bird transmission exists. Because of the mild, self-limited infection of humans by NDV, the risk of substantial illness and pandemics is unlikely. Multiple treatments of humans with NDV administered by inhalation⁵⁴ or IV⁵⁵ without substantial adverse effects are further evidence that the risk of severe illness is low, although low-grade fevers that subsided in 24 hours did occur after inhalation therapy in 8 of 23 vaccine-treated patients. In the inhalation studies, it was also noted that mild conjunctivitis was a consequence of accidental eye inoculation..."

http://www.avma.org/reference/zoonosis/znainewcastle.asp

[Treyfish]

Re: Indonesia HUMAN Cases - Mar/2/2008+

They would be glad to tell you "it was only a Newcastle disease variant.Have to ask Dr niman what the recombination chances are and what the results might be.Then add some dengue/chik to the mix...

[Commonground]

Re: Indonesia HUMAN Cases - Mar/2/2008+

Oracle, I'm not sure where you are referring to..when you say "here"?

Yet here, we have within the last few weeks, several clusters where these patients survived and were discharged. In some cases, bird deaths were reported, but H5N1 in home or nearby poultry was not confirmed.

[Giuseppe]

Re: Indonesia HUMAN Cases - Feb 4, 2007+

Noted the comment on blood test fallability.

I would like to advance an alternative explanation

I think we have a new, virulent strain of New Castle disease emerging in particular areas of Indonesia. NDV is known to cause disease in humans, usually from direct aerosol contact (in lab, by veterinarians or handling of infected poultry).

In the cases where families clusters (parent, offspring) were treated with tamiflu, and where disease rapidly progressed to a point requiring ventilllators, survival is usually dismal. Yet here, we have within the last few weeks, several clusters where these patients survived and were discharged. In some cases, bird deaths were reported, but H5N1 in home or nearby poultry was not confirmed.

Perhaps it's time for WHO and the CDC to take a close look at the NDV strains in these Indonesian human H5N1- cases, where bird deaths were investigated, and reported to be infected with NDV, rather than HPAI.

It would be a rather interesting development.

It may be.
-
Isolation of Avian Paramyxovirus 1 from a Patient with a Lethal Case of Pneumonia
Scott J. Goebel,1 Jill Taylor,1 Bradd C. Barr,2 Timothy E. Kiehn,3 Hugo R. Castro-Malaspina,3 Cyrus V. Hedvat,3 Kim A. Rush-Wilson,1 Cassandra D. Kelly,1 Stephen W. Davis,1 William A. Samsonoff,1 Kelley R. Hurst,1 Melissa J. Behr,1 and Paul S. Masters1*
Divisions of Infectious Disease and Molecular Medicine, Wadsworth Center, New York State Department of Health, Albany, New York 12201,1 California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California, Davis, California 95616,2 Departments of Clinical Laboratories, Medicine, and Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 100213
*Corresponding author. Mailing address: David Axelrod Institute, Wadsworth Center, NYSDOH, New Scotland Avenue, P.O. Box 22002, Albany, NY 12201-2002. Phone: (518) 474-1283. Fax: (518) 473-1326. E-mail: masters@wadsworth.org
Received June 27, 2007; Accepted September 4, 2007.

Abstract
An unknown virus was isolated from a lung biopsy sample and multiple other samples from a patient who developed a lethal case of pneumonia following a peripheral blood stem cell transplant.
A random PCR-based molecular screening method was used to identify the infectious agent as avian paramyxovirus 1 (APMV-1; a group encompassing Newcastle disease virus), which is a highly contagious poultry pathogen that has only rarely been found in human infections.
Immunohistochemical analysis confirmed the presence of APMV-1 antigen in sloughed alveolar cells in lung tissue from autopsy.
Sequence from the human isolate showed that it was most closely related to virulent pigeon strains of APMV-1.
This is the most completely documented case of a systemic human infection caused by APMV-1 and is the first report of an association between this virus and a fatal disease in a human.

-

http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2168997&rendertype=abstract

-----

[Commonground]

Re: Indonesia HUMAN Cases - Mar/2/2008+

[Another area where we have both H5N1 in the poultry & Dengue. Also, I have approx. 16 miles between Klaten, SD (37) & FH (9) neg; and Sleman]

Totalling 611 Poultry In Sleman Died Positive AI
Rabu, 5 Maret 2008 - 00:41 wib
The field of Peternakan Regional Government Sleman said till March the first week, 611 poultries in Sleman Yogyakarta died positive was infected by the virus of Avian Influenza (AI).
According to the Head of the Peternakan Sleman Suwandi Azis Field, this number was higher compared with the month that was same in the year beforehand.
Nevertheless Azis stressed during June/in July last year did not have the poultry in Sleman that died positive AI.
Azis also stressed the poultry died most resulting from AI was in the Turi subdistrict around 162 tails, followed afterwards the Ngaglik subdistrict 133 tails.
The two subdistricts according to Azis quite high the poultry figure that died positive AI, and it was estimated because of the mutation of the quite solid poultry.
"Di Antara two subdistricts indeed his case was rather high compared to dawerah other.
I did not know persisi whether the mutation of his poultry was high or how that we explained will try to continue to monitor two subdistricts," revealed Azis, on Tuesday (4/3/2008)
-snip-

http://news.okezone.com/index.php/ReadStory/2008/03/05/1/89021

Aircraft passengers could be suspected of spreading DBD
08 Maret 2008
Sleman - You liked to go on a trip by rising the aircraft?
From now on big-hearted-heart because aircraft passengers could be at this time suspected of becoming the disseminator of the virus of the illness of dengue fever dengue fever (DBD).
This assumption was raised by the Head of the Community Health Centre Depok I the doctor Omar Indroyono in his explanation in Pendapa Kecamatan Depok, recently.
That was sent by him in the Management agenda of the Penanggulangan Working Group (Pokjanal) DBD Kabupaten Sleman remembered the mobility of the person in the Adisutjipto Airport very high both the arrival and the trip from where and anywhere.
The community health centre Depok I supervised the Caturtunggal Village territory and Maguwoharjo, Kecamatan Depok.
Including also the Adisutjipto Airport region.
He did not raise the foundation of his prediction whether researched passengers who came or not yet.
-snip-

In the meantime, up to the beginning of this March has been gotten by 33 DBD cases, one among them died.

Up to the beginning of this March there was found by 21 cases and all of them were stated recovered.

http://suaramerdeka.com/smcetak/index.php?fuseaction=beritacetak.detailberitacetak&id_beritacetak=3952

[Gert van der Hoek]

Re: Indonesia HUMAN Cases - Mar/2/2008+

From Sulawesi, a child suspect bird flu, no details; could be the child mentioned yesterday, released from hospital, went home.

CHICKEN continued to be enjoyed in MAKASSAR

09 Maret 2008 20:17

The chicken request in the centres of the sale of the piece chicken in Makassar, Sulawsi Selatan, stayed stable.

In fact, the case of the chicken died as a result of lustre bird flu in this territory.

At this time also had a child who was treated it was suspected to be infected by bird flu.

In sale centres of the piece chicken in Street Abu Bakar Lambogo, Kota Makassar, busy the buyer.

Maryati, one of the traders claimed to be the sale of his chicken could reach 700 tails per the day.

In fact, his price has risen from Rp 25 thousand became Rp 29 thousand per the tail.

The case of bird flu spread again in Makassar, South Sulawesi, after dozens of tails of the chicken in the Complex of Ikatan Doctor Indonesia, Kelurahan Antang, Kecamatan Manggala, died suddenly.

Officially the local health confirmed these chickens were positive bird flu.

http://www.metrotvnews.com/berita.asp?id=55014

[Gert van der Hoek]

Re: Indonesia HUMAN Cases - Mar/2/2008+

Condition of patient in Bandung Hospital improved

10/03/2008 07:08 Flu Burung

Kondisi Pasien Dugaan Flu Burung di Bandung Membaik

Liputan6.com, Bandung: Setelah menjalani perawatan selama lima hari, pasien dugaan flu burung asal Bandung, Jawa Barat, Ahad (9/3), kondisinya sudah membaik. Pasien saat ini sudah tidak menggunakan alat bantu pernapasan. Ia adalah pasien ke-112 yang diduga terjangkit virus flu burung.

Berdasarkan hasil uji sampel darah Serta cairan tubuh pada hari pertama menunjukan hasil negatif. Namun ia masih dirawat di Ruang Flamboyan Rumah Sakit Hasan Sadikin, Bandung, Jabar. Sementara pengujian untuk hari kedua dan ketiga di Balai Penelitian dan Pengembangan Kesehatan (Balitbangkes) Jakarta diperkirakan selesai satu hingga dua hari mendatang.(JUM/Patria-Taufik Hidayat)

http://www.liputan6.com/daerah/?id=156031

[Giuseppe]

Re: Indonesia HUMAN Cases - Mar/2/2008+

Condition of patient in Bandung Hospital improved

10/03/2008 07:08 Flu Burung

Kondisi Pasien Dugaan Flu Burung di Bandung Membaik

Liputan6.com, Bandung: Setelah menjalani perawatan selama lima hari, pasien dugaan flu burung asal Bandung, Jawa Barat, Ahad (9/3), kondisinya sudah membaik. Pasien saat ini sudah tidak menggunakan alat bantu pernapasan. Ia adalah pasien ke-112 yang diduga terjangkit virus flu burung.

Berdasarkan hasil uji sampel darah Serta cairan tubuh pada hari pertama menunjukan hasil negatif. Namun ia masih dirawat di Ruang Flamboyan Rumah Sakit Hasan Sadikin, Bandung, Jabar. Sementara pengujian untuk hari kedua dan ketiga di Balai Penelitian dan Pengembangan Kesehatan (Balitbangkes) Jakarta diperkirakan selesai satu hingga dua hari mendatang.(JUM/Patria-Taufik Hidayat)

http://www.liputan6.com/daerah/?id=156031

[TTT]
The condition for the Patient the Assumption of Bird Flu in Bandung improved
Liputan6.com, Bandung: After undergoing the maintenance for five days, the assumption patient of bird flu from Bandung, West Java, Ahad (9/3), his condition has improved.
The patient at this time already did not use respiratory aids.
He was the patient 112 that was expected terjangkit the bird flu virus.
Was based on results of the sample test of blood As Well As body fluids in the first day menunjukan results of the negative.
However he was still being treated in Flamboyan Rumah Sakit Hasan Sadikin Space, Bandung, West Java.
Now the testing during the second and third day in the Penelitian Dan Pengembangan Kesehatan Hall (Balitbangkes) Jakarta it was estimated was finished one till the next two days.
(JUM/Patria-Taufik Hidayat)

[Commonground]

Re: Indonesia HUMAN Cases - Mar/2/2008+

New Case
Map of Sumedang, West Java: http://tinyurl.com/2e7y3s

An, 35, the resident of the Ciakar Village, Desa Cimarias, of Kecamatan Pamulihan, Kabupaten Sumedang was treated in Isolasi Cempaka RSUD Sumedang Space.
An was it was suspected attacked by the bird flu illness (avian influenza).
The trader peuyeum [?] this experienced deman high after three chickens that were maintained at the edge of his house died suddenly, was followed afterwards belasan the tail of the chicken belonging to his neighbour in Cimarias.
Entin, 29, the wife An said, his husband entered Cempaka Space since Monday (10/3) struck 13,00 WIB. One day previous, the husband who gave him one child was 10 years old the high fever after three chickens maintained him died suddenly.
Because never recovered and even increasingly serious, Entin then brought his husband to the Haurgombong Community Health Centre before finally was reconciled to RSUD Sumedang.

"That just suspect, his blood was sent to the laboratory.
But if his diagnosis the TB, so waited results previously," he said.
Section Head Kesehatan (Dinkes) Sumedang Hilman Taufik confirmed had a patient suspect bird flu from Cimarias that entered RSUD Sumedang.
"Although was just expected, but because the condition for his body weakened must be guarded against by us," mentioned him to the reporter.
On a separate occasion, Section Head Peternakan and fisheries (Disnakan) Sumedang Ade Gunatara added, An indeed had the story of contact with the chicken before the high fever.
Three kept An chickens died suddenly.
The case of the chicken died suddenly, added Ade, also could happen in the Neglasari Village that berte-ladder with Ciakar around the last one weeks.
"We got the report around 60 chickens in Neglasari died suddenly.
We direct to remove the sample of blood.
Results of the chickens were positive bird flu," he
accused

http://www.seputar-indonesia.com/edisicetak/jawa-barat/rsud-rawat-suspect-flu-burung.html