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Emerg Infect Dis. Experimental Infection of Dogs with Avian-Origin Canine Influenza A Virus (H3N2)
Experimental Infection of Dogs with Avian-Origin Canine Influenza A Virus (H3N2) [CDC EID]
Experimental Infection of Dogs with Avian-Origin Canine Influenza A Virus (H3N2)
Daesub Song, Chulseung Lee, Bokyu Kang, Kwonil Jung,1 Taehoon Oh, Hyekwon Kim, Bongkyun Park, and Jinsik Oh1
Author affiliations: Green Cross Veterinary Products, Yong-in, South South Korea (D. Song, C. Lee, B. Kang, T. Oh); Daewoong Pharmaceutical Company, Kyounggi-Do, South Korea (K. Jung); Animal Genetics, Inc., Suwon, South Korea (H. Kim, B. Park); and Seoul National University, Seoul, South Korea (J. Oh)
Abstract
Susceptible dogs were brought into contact with dogs experimentally infected with an avian-origin influenza A virus (H3N2) that had been isolated from a pet dog with severe respiratory syndrome.
All the experimentally infected and contact-exposed dogs showed elevated rectal temperatures, virus shedding, seroconversion, and severe necrotizing tracheobronchitis and bronchioalveolitis.
Transmission of highly pathogenic avian-origin canine influenza A viruses (H3N2) that spread across South Korea during May through December 2007 was observed repeatedly in the country's animal clinics (1).
These viruses share >97% nucleotide sequence homology, suggesting that whole viruses were transmitted directly from birds to dogs.
To determine whether these viruses can be transmitted directly from dog to dog, we experimentally infected beagles by direct contact.
Dog-to-dog transmission of the virus raises questions about the interspecies transmission of avian influenza viruses and adaptation of these viruses to canine physiology.
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<cite cite="http://www.cdc.gov/eid/content/15/1/56.htm">Avian-Origin Canine Influenza Virus | CDC EID</cite>
Daesub Song, Chulseung Lee, Bokyu Kang, Kwonil Jung,1 Taehoon Oh, Hyekwon Kim, Bongkyun Park, and Jinsik Oh1
Author affiliations: Green Cross Veterinary Products, Yong-in, South South Korea (D. Song, C. Lee, B. Kang, T. Oh); Daewoong Pharmaceutical Company, Kyounggi-Do, South Korea (K. Jung); Animal Genetics, Inc., Suwon, South Korea (H. Kim, B. Park); and Seoul National University, Seoul, South Korea (J. Oh)
Abstract
Susceptible dogs were brought into contact with dogs experimentally infected with an avian-origin influenza A virus (H3N2) that had been isolated from a pet dog with severe respiratory syndrome.
All the experimentally infected and contact-exposed dogs showed elevated rectal temperatures, virus shedding, seroconversion, and severe necrotizing tracheobronchitis and bronchioalveolitis.
Transmission of highly pathogenic avian-origin canine influenza A viruses (H3N2) that spread across South Korea during May through December 2007 was observed repeatedly in the country's animal clinics (1).
These viruses share >97% nucleotide sequence homology, suggesting that whole viruses were transmitted directly from birds to dogs.
To determine whether these viruses can be transmitted directly from dog to dog, we experimentally infected beagles by direct contact.
Dog-to-dog transmission of the virus raises questions about the interspecies transmission of avian influenza viruses and adaptation of these viruses to canine physiology.
-