China: Woman, 19, Confirmed H5N1 Death - Contacts Monitored

[Sally Furniss]

City lift the human avian influenza major public health emergencies Ⅱ-class emergency response

Time :2009-01-14 Source: Beijing Municipal Health Bureau here: 72

At 12:00 on January 12, the Beijing Municipal Public Health Emergency Command Office of the full lifting of the 200 bird flu patients with celebrities of close contacts under medical observation. At present, the city no animal bird flu report, issued no new human bird flu cases and suspected cases reported. The bird flu ward, medical waste and dead bodies in close contact with disinfection and quarantine work places has ended, related to the epidemiological investigation, specimen collection and virus isolates the work has been completed. The human infection of highly pathogenic avian influenza epidemic and related problems has been to control risk factors.

January 13, the city Health Bureau held a human avian influenza expert meeting to assess the city's human bird flu contingency disposal and prevention and control work. Expert Group agreed to lift the city's human avian influenza major public health emergencies Ⅱ-class emergency response recommendations. City Public Health Emergency Command Office in accordance with the "Beijing public health emergencies contingency plans" and "Beijing people to deal with avian flu pandemic contingency plan" provides for the City of avian influenza recommendations of the Expert Meeting, decided in January 24 pm on the 13th, lifting the city's human bird flu a major public health emergencies Ⅱ-class emergency response.

January 5, 2009 as early as 7:20, the city occurred in case of human infection of highly pathogenic avian influenza deaths. At 17:00 on January 6, the city of avian flu were to start a major public health emergencies II-class emergency response. The city's disease prevention and control centers each day engaged in poultry breeding, slaughtering, marketing and monitoring of occupational exposure to poultry takes the initiative to monitor the crowd. As of January 12, a total of 30,1995 people monitoring. In addition, pro-active monitoring of the floating population views 5,7957; deep into the communities and rural families, households to carry out pro-active monitoring of influenza views 125,9335; the city's medical institutions at all levels, all kinds of doors (urgent) patient monitoring reported cases of influenza 1,2823 kind of cases, on the 6706 samples were carried out for rapid detection of influenza virus, no one suspected cases of bird report.

Municipal Health Bureau took the initiative to agriculture, industry and commerce, transportation, municipal, Drug Administration, Education and other departments for information communication and cooperation. Municipal Agriculture Bureau active immunization and antibodies to monitor poultry, live birds outside the prohibition of Beijing; the city of Commerce and Industry Bureau to strengthen the poultry market circulation area of inspection and market supervision; City Department of Finance to establish human avian influenza and avian flu prevention and control of financial security mechanisms; City Tourism Bureau strict food stock clearance, do a good job in travel and accommodation team personnel registration and observation; City Board of Education to seriously do a good job in the morning, afternoon seized school students, such as health care work, strict enforcement of public health emergencies of information reporting system. The city's human avian flu prevention and control work to deal with emergencies and achieved remarkable results.

http://www.bjhb.gov.cn/news.do?dispa...dById&id=22721

[Treyfish]

Fatal Avian Influenza Case in Beijing

The Chinese government announced on January 6 the death of a Beijing woman from highly pathogenic H5N1 avian influenza. The announcement indicates that this person contracted the disease from cleaning the internal organs of ducks bought in a market in Hebei Province. It also states that no other individuals have been found to be infected, and that there are currently no sick or dead birds in the region.
One week ago, a child from Shenzhen Province was infected with a less virulent version of H9N2 avian influenza and hospitalized. She has since recovered and has been discharged from the hospital.
Since 2003, China has reported that 31 people have contracted highly pathogenic H5N1 avian influenza; 21 of them have died. This new death is the first in a year. Recent prevention and control measures may be responsible for the decrease in infections and deaths. All but one of the cases has a documented history of direct contact with birds or probable direct contact with infected birds. (In December 2008, a father became infected while caring for his fatally infected son in hospital without observing recommended hospital infection control practices. He was exposed to large amounts of infected body fluids; such exposure could not happen during the routine activities of daily life). Although these cases are rare, the U.S. Government continues to pay very close attention to the highly pathogenic H5N1 virus in China (and worldwide), in case it mutates over time to become transmissible from human to human.
The people at greatest risk for contracting highly pathogenic avian influenza are poultry workers, who in unsanitary conditions can become infected by inhaling the virus from infected birds, or transplanting the virus from contaminated hands to mouth. Thus, raising and slaughtering birds is discouraged. In addition, the following steps are recommended when handling poultry products:

• Wash hands for at least 20 seconds before and after handling fresh poultry and or eggs;
• Prevent cross-contamination by keeping poultry and their juices away from other foods;
• Wash hands for at least 20 seconds, cutting board, knife, and counter tops with hot, soapy water after cutting raw poultry;
• Sanitize cutting boards and other utensils by using a solution of 1 teaspoon chlorine bleach in 1 quart of water; and,

Use a food thermometer to ensure food has reached the safe internal temperature—in all parts of the bird. Cook poultry to at least 165° F (74° C) to kill food borne germs that might be present, including the avian influenza virus.
For further information about Avian Influenza, please consult the United States Centers for Disease Control web site at http://www.cdc.gov/flu/avian/ or the U.S. State Department fact sheet at http://travel.state.gov/travel/tips/health/health_1181.html.
For the latest security information, Americans living and traveling abroad should regularly monitor the Department’s Bureau of Consular Affairs Internet web site at http://travel.state.gov, where the current Worldwide Caution, Travel Alerts, and Travel Warnings can be found. Up-to-date information on security can also be obtained by calling 1-888-407-4747 toll free in the U.S. or Canada, or, for callers outside the U.S. and Canada, a regular toll line at 1-317-472-2328. These numbers are available from 8:00 a.m. to 8:00 p.m. Eastern Time, Monday through Friday (except U.S. federal holidays).
The U.S. Embassy can be reached 24 hours per day at 86-10-8531-4000. The addresses and telephone contact information for the U.S. Embassy and Consulates are at the bottom of this announcement.
U.S. citizens residing or traveling in China are reminded to register with the U.S. Embassy or closest U.S. Consulate by entering your travel itinerary and contact information at: https://travelregistration.state.gov/ibrs. In case of difficulties registering online, please contact the closest U.S. Embassy or Consulate.
U.S. Embassy Beijing: Tian Ze Road Intersection of An Jia Lou Road, Chaoyang District. Telephone number during regular business hours and for after hours emergencies: 86-10-8531-4000, Email: amcitbeijing@state.gov. Embassy’s website: beijing.usembassy-china.org.cn.
U.S. Consulate General Chengdu: Number 4, Lingshiguan Road, Section 4, Renmin Nanlu, Chengdu 610041, tel. 86-28-8558-3992 Email: consularchengdu@state.gov. For after hours emergencies, please call 86-28-1370-800-1422.
U.S. Consulate General Guangzhou: The Consular Section is located at 5th Floor, Tianyu Garden (II phase), 136-146 Lin He Zhong Lu, Tianhe District, Guangzhou 510133, tel. 86-20-8518-7605; Email:GuangzhouACS@state.gov. Guangzhou adoptions Email: GuangzhouA@state.gov. For after hours emergencies, please call 86-20-8121-8000.
U.S. Consulate General Shanghai: The Consular Section is located in the Westgate Mall, 8^th Floor, 1038 Nanjing Xi Lu, Shanghai 200041; tel. 86-21-3217-4650, Email: Shanghaiacs@state.gov. For after hours emergencies, please call 86-21-6433-3936.
U.S. Consulate General Shenyang: No. 52, 14^th Wei Road, Heping District, Shenyang 110003; tel. 86-24-2322-1198, Email: ShenyangACS@state.gov. For after hours emergencies, please call 86-24-137-0988-9307.

http://beijing.usembassy-china.org.cn/wm010909u.html

[HenryN]

January 13, 2009 Beijing conference communique Disease Prevention

时间：2009-01-14来源：北京市卫生局 Time :2009-01-14 Source: Beijing Municipal Health Bureau

2009年1月12日，全北京市疾控机构对从事禽类养殖、屠宰、销售和监控等职业的高危人群和重点人群开展 主动监测，共监测50029人，未发现流感样病例。 January 12, 2009, all agencies engaged in disease control in Beijing poultry breeding, slaughtering, marketing and monitoring of high-risk groups, such as occupational and focus groups to carry out pro-active monitoring to monitor a total of 50,029 people, found no influenza-like cases. 对外地在京流动人口开展主动监测，共监测9731人，未发现流感样病例。 External to the floating population in Beijing to carry out pro-active monitoring to monitor a total of 9731 people found no cases of influenza-like. 全市各级各类医疗机构门、急诊病例监测无人禽流感病例或医学观察病例报告，开展不明原因肺炎病例监测与排查，没有不明原因肺 炎病例报告，共监测报告流感样病例1897例。 The city at all levels of medical institutions doors, emergency cases to monitor bird flu or no medical observation reported cases of pneumonia of unknown causes to carry out monitoring and investigation of cases, no cases of pneumonia of unknown causes reports, monitoring reports a total of 1897 cases of influenza-like cases. 全市疾控机构对医疗机构所报告的流感样病例开展了流行病学调查和追访，共调查和追访2256例，对1552 人进行了流感快速检测，27人为阳性。 The city's disease control agency of medical institutions reported cases of influenza-like carried out epidemiological investigations, and追访, a total of 2256 cases of the investigation and追访of 1552 people conducted a rapid detection of influenza, 27 man-made positive. 未发现可疑人禽流感病例。 Found no suspicious cases of human avian influenza. 全市疾控机构开展流感入户主动监测167898人，未发现可疑人禽流感病例。 The city's disease control agency to carry out pro-active monitoring of influenza 167,898 households, and found no suspicious cases of human avian influenza. 北京市疾控中心共接到流感样病例采样样本39件，已检测39件，结果均为H5N1核酸阴性。 Beijing CDC has received cases of influenza-like samples 39 samples have been detected 39, the results were negative for H5N1 nucleic acid. 自开展应急监测以来，各区县共送检应急监测患者的样本174件，已检测174件，结果均为H5N1核酸阴性 。 Since the emergency monitoring carried out since the submission of the district and county emergency monitoring in patients with a total sample of 174, 174 have been detected, the results were negative for H5N1 nucleic acid. 1月12日，全市无新增人禽流感病例密切接触者，累计人禽流感病例密切接触者200人，目前已全部解除医学 观察，密切接触者中无异常症状报告。 January 12, the city no additional people in close contact with bird flu, the cumulative cases of human avian influenza in close contact with 200 people, has all the lifting of medical observation and close contact with those who report no abnormal symptoms. 1月12日，市疾控中心接到中国疾控中心报告，自北京市人禽流感病例右肺组织分离的病毒（A/Beijing/1/2009（H5N1）基因序列分析结果：该病毒与我国2005-2008年分离的禽流感病毒无本质区别，仅有很小变异；该病毒没有发现与人流感病毒的重配，仍为禽源。该结 果表明，该病毒仍然不易造成人与人之间的传播。另外，中国疾控中心已经自河北省疾控中心采集的环境标本中分 离到禽流感病毒，基因测序正在进行中。 January 12, the city of CDC received a report of the Chinese CDC, since the human avian influenza cases in Beijing right lung tissue isolation of the virus (A/Beijing/1/2009 (H5N1) Gene sequence analysis of the results: the virus and China 2005-2008 Separation of avian influenza virus without the essential difference between, only a very small variation; the virus have not found with the human influenza virus re-allocated at the source of poultry. The results showed that the virus is still not easy to cause human-to-human spread. In addition, China's CDC has been collected from Hebei Province CDC environmental samples isolated from avian influenza virus, gene sequencing is in progress. 1月12日，12320热线共接到群众对人禽流感问题的咨询电话16件，其中知识咨询10件，了 解疫情情况2件，疫情举报3件，诊治咨询1件。 January 12, the hotline received a total of 12,320 people on the issue of human avian influenza Tel 16, of which 10 advisory knowledge to understand the epidemic situation of 2, 3 to report the epidemic situation, a diagnosis and treatment advice. 全市各区县疾控中心共发放市级统一印制宣传海报11955张、折页272800、自制宣传单31795张， 宣传板57块，折页23386份，报纸28001张，海报20张、宣传横幅55条，其他宣传品7260份； 开展健康大课堂24场，受益群众1120人；开展咨询活动43次，受益群众1569人；召开宣传工作会议47次，参 加人数932人；在区县及单位电视台播出7套流感与人禽流感防治知识节目；在区县广播播出人禽流感防治知识 182次，利用区县及单位网络刊登15篇流感与人禽流感防治知识文章；32条信息在医疗机构及社区电子滚动 屏播出。 The city's various districts and counties were issued CDC unified municipal publicity posters 11955, 272800 folding, made 31,795 fliers, advertisements 57, folding 23,386 copies, 28,001 newspapers, posters, 20, publicity banner 55 , and other promotional materials were 7260; Health Big Classroom 24, 1120 to benefit the masses; and advisory activities carried out 43 times, 1569 to benefit the masses; and publicity work conference held 47 times the number of participants 932 people; in the districts and units broadcast 7 sets of influenza and human bird flu prevention knowledge programs; radio broadcast in the district and county human avian influenza prevention and control knowledge 182 times, the use of districts and 15 units of the network published influenza and human bird flu prevention and control knowledge of the article; 32 information in the medical institutions and community electronic rolling screen broadcast.

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[HenryN]

Originally Posted by niman

http://translate.google.com/translat...L_enUS305US306

Small variations can have large effects.

[HenryN]

Commentary

http://www.recombinomics.com/News/01..._Mismatch.html

[AlaskaDenise]

[quote=niman;203092]Commentary

http://www.recombinomics.com/News/01190903/H5N1_China_Mismatch.html[/quote]

Commentary
Vaccine Resistant Asymptomatic H5N1 in China Raises Concerns
Recombinomics Commentary 15:47
January 19, 2009

According to the Chinese CDC report, based on human avian influenza cases in Beijing right lung tissue isolation of the virus (A/Beijing/1/2009 (H5N1) Gene sequence analysis of the results: the virus with China from 2005 to 2008 the separation of poultry no essential difference between the flu virus, only a very small variation.

The results showed that the virus did not happen with the human influenza virus re-allocation, which proved the source of infection is still Huang poultry source.

The above comments attributed to the Chinese CDC indicate the sequences from the fatal case in Beijing (A/Beijing/1/2009) do not have evidence of reassortment, but there are small variations. The relationship of these sequences to prior human isolates in China remains unclear.

Most cases in China are clade 2.3.4 (Fujian strain), which was isolated in Fujian Province 2005 from poultry, but links back to H5N1 from Fujian province in 2003. Similarly clade 7 has been isolated between 2005 and 2008 in northern China and Hunan, but links back to a fatal case in Beijing in 2003.

However, the most recent reported H5N1 outbreaks in poultry in China were in Jiangsu in December, 2008. Although more than 300,000 birds were culled, there were no reported deaths listed in the OIE report, indicating the poultry infection was asymptomatic and sequence analysis indicated the H5N1 was clade 7.

That outbreak has been followed by found confirmed cases in China (see updated map) in the past two weeks in Beijing, Shandong, Guizhou, and Hunan. Although the human cases were widespread throughout China, there have been no confirmations of H5N1 in poultry in these areas, raising concerns that H5N1 was being transmitted to these victims from asymptomatic poultry.

Asymptomatic poultry can be generated by mismatched vaccines. The cross reactivity of the vaccination keeps the host healthy, but virus is shed, raising concerns of spread to unvaccinated hosts, such as wild birds or humans.

Moreover, co-circulation of H5N1 can give rise to evolved versions of H5N1 that can have altered tissue tropism or host ranges, especially in changes in the receptor binding domain are acquired.

Clade 7 sequences from the 2006 outbreak in Shanxi in 2006 have been released, and these sequences are distinct from clade 1 or clade 2, and have a number of receptor binding domain changes. These changes could switch genetic backgrounds via recombination, as has been seen in anti-vital resistance in seasonal flu, where receptor binding domain changes in H3N2 and H1N1 have been associated worldwide fixing of H274Y in NA or S31N in M2.

Release of sequences from the poultry outbreaks in Jiangsu, as well as confirmed human cases this month, would be useful.

[Commonground]

Blog:

Bird flu death 19-year-old girl of her life in the last nine days (Photo) [转帖2009.01.20 05:55:09]


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