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Old February 21st, 2009, 01:47 PM
Giuseppe Michieli's Avatar
Giuseppe Michieli Giuseppe Michieli is offline
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History Epidemiol Infect. A comparative study of the 1918-1920 influenza pandemic in Japan, USA and UK: mortality impact and implications for pandemic planning.

Epidemiol Infect. 2009 Feb 12:1-11. [Epub ahead of print]

A comparative study of the 1918-1920 influenza pandemic in Japan, USA and UK: mortality impact and implications for pandemic planning.

Richard SA, Sugaya N, Simonsen L, Miller MA, Viboud C. - Fogarty International Center, National Institutes of Health, Bethesda, MD, USA.

SUMMARY
Historical studies of influenza pandemics can provide insight into transmission and mortality patterns, and may aid in planning for a future pandemic. Here, we analyse historical vital statistics and quantify the age-specific mortality patterns associated with the 1918-1920 influenza pandemic in Japan, USA, and UK. All three countries showed highly elevated mortality risk in young adults relative to surrounding non-pandemic years. By contrast, the risk of death was low in the very young and very old. In Japan, the overall mortality impact was not limited to winter 1918-1919, and continued during winter 1919-1920. Mortality impact varied as much as threefold across the 47 Japanese prefectures, and differences in baseline mortality, population demographics, and density explained a small fraction of these variations. Our study highlights important geographical variations in timing and mortality impact of historical pandemics, in particular between the Eastern and Western hemispheres. In a future pandemic, vaccination in one region could save lives even months after the emergence of a pandemic virus in another region.

PMID: 19215637 [PubMed - as supplied by publisher]
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