tetano
Editor, Senior Moderator
Chembiochem. 2012 Sep 10. doi: 10.1002/cbic.201200439. [Epub ahead of print]
A Chemically Programmed Antibody Is a Long-Lasting and Potent Inhibitor of Influenza Neuraminidase.
Hayakawa M, Toda N, Carrillo N, Thornburg NJ, Crowe JE Jr, Barbas CF 3rd.
Source
Departments of Chemistry, Molecular Biology, and, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA).
Abstract
Programming an anti-flu strategy: A new and potent neuraminidase inhibitor that maintains long-term systemic exposure of an antibody and the therapeutic activity of the neuraminadase inhibitor zanamivir has been created. This strategy could provide a promising new class of influenza A drugs for therapy and prophylaxis, and validates enzyme inhibitors as programming agents in synthetic immunology.
Copyright ? 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PMID:
22965667
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22965667
A Chemically Programmed Antibody Is a Long-Lasting and Potent Inhibitor of Influenza Neuraminidase.
Hayakawa M, Toda N, Carrillo N, Thornburg NJ, Crowe JE Jr, Barbas CF 3rd.
Source
Departments of Chemistry, Molecular Biology, and, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA).
Abstract
Programming an anti-flu strategy: A new and potent neuraminidase inhibitor that maintains long-term systemic exposure of an antibody and the therapeutic activity of the neuraminadase inhibitor zanamivir has been created. This strategy could provide a promising new class of influenza A drugs for therapy and prophylaxis, and validates enzyme inhibitors as programming agents in synthetic immunology.
Copyright ? 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PMID:
22965667
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22965667