tetano
Editor, Senior Moderator
Neuroepidemiology. 2015 Aug 29;45(2):90-99. [Epub ahead of print]
[h=1]A Multicentric Prospective Incidence Study of Guillain-Barr? Syndrome in Italy. The ITANG Study.[/h] Benedetti MD[SUP]1[/SUP], Pugliatti M, D'Alessandro R, Beghi E, Chi? A, Logroscino G, Filippini G, Galeotti F, Massari M, Santuccio C, Raschetti R; ITANG Study Group.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] To assess Guillain-Barr? syndrome (GBS) incidence we relied on the Italian Network for the study of GBS (ITANG) established in 2010 in 7 Italian regions to analyse the association between influenza vaccination and GBS.
[h=4]METHODS:[/h] All individuals aged ≥18 years, presenting with clinical manifestations that suggested GBS according to the universally accepted Asbury's diagnostic criteria (1990) were prospectively notified to a centralised database by ITANG neurologists over the period October 1, 2010-September 30, 2011. Through a telephone survey, 9 trained interviewers followed up the cases to diagnosis and then for 1 year since hospital discharge. Validation of case reporting was performed with the support of administrative data in 5 regions.
[h=4]RESULTS:[/h] We found 365 cases fulfilling the definition for GBS or one of its variants over 19,846,068 population ≥18 years of age, yielding an annual incidence rate of 1.84 per 100,000 (95% CI 1.65-2.03), 2.30 (95% CI 1.99-2.60) in men and 1.41 (95% CI 1.18-1.64) in women. A highly significant peak of incidence was observed in February 2011 as compared to reference month (September 2011, rate ratio 3.3:1, p < 0.01).
[h=4]CONCLUSIONS:[/h] In Italy, GBS incidence was among the highest reported in Europe and higher than previously observed in Italian studies.
? 2015 S. Karger AG, Basel.
PMID: 26329724 [PubMed - as supplied by publisher]
[h=1]A Multicentric Prospective Incidence Study of Guillain-Barr? Syndrome in Italy. The ITANG Study.[/h] Benedetti MD[SUP]1[/SUP], Pugliatti M, D'Alessandro R, Beghi E, Chi? A, Logroscino G, Filippini G, Galeotti F, Massari M, Santuccio C, Raschetti R; ITANG Study Group.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] To assess Guillain-Barr? syndrome (GBS) incidence we relied on the Italian Network for the study of GBS (ITANG) established in 2010 in 7 Italian regions to analyse the association between influenza vaccination and GBS.
[h=4]METHODS:[/h] All individuals aged ≥18 years, presenting with clinical manifestations that suggested GBS according to the universally accepted Asbury's diagnostic criteria (1990) were prospectively notified to a centralised database by ITANG neurologists over the period October 1, 2010-September 30, 2011. Through a telephone survey, 9 trained interviewers followed up the cases to diagnosis and then for 1 year since hospital discharge. Validation of case reporting was performed with the support of administrative data in 5 regions.
[h=4]RESULTS:[/h] We found 365 cases fulfilling the definition for GBS or one of its variants over 19,846,068 population ≥18 years of age, yielding an annual incidence rate of 1.84 per 100,000 (95% CI 1.65-2.03), 2.30 (95% CI 1.99-2.60) in men and 1.41 (95% CI 1.18-1.64) in women. A highly significant peak of incidence was observed in February 2011 as compared to reference month (September 2011, rate ratio 3.3:1, p < 0.01).
[h=4]CONCLUSIONS:[/h] In Italy, GBS incidence was among the highest reported in Europe and higher than previously observed in Italian studies.
? 2015 S. Karger AG, Basel.
PMID: 26329724 [PubMed - as supplied by publisher]