tetano
Editor, Senior Moderator
Acta Pharmacol Sin
. 2020 Aug 3.
doi: 10.1038/s41401-020-0485-4. Online ahead of print.
Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19
Yuan Huang[SUP] 1 [/SUP], Chan Yang[SUP] 1 [/SUP], Xin-Feng Xu[SUP] 1 [/SUP], Wei Xu[SUP] 2 [/SUP], Shu-Wen Liu[SUP] 3 4 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 is a newly emerging infectious disease currently spreading across the world. It is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spike (S) protein of SARS-CoV-2, which plays a key role in the receptor recognition and cell membrane fusion process, is composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain that recognizes and binds to the host receptor angiotensin-converting enzyme 2, while the S2 subunit mediates viral cell membrane fusion by forming a six-helical bundle via the two-heptad repeat domain. In this review, we highlight recent research advance in the structure, function and development of antivirus drugs targeting the S protein.
Keywords: SARS-CoV-2 virus; antibodies; antivirus drugs; fusion inhibitors; host proteases inhibitors; spike protein.
. 2020 Aug 3.
doi: 10.1038/s41401-020-0485-4. Online ahead of print.
Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19
Yuan Huang[SUP] 1 [/SUP], Chan Yang[SUP] 1 [/SUP], Xin-Feng Xu[SUP] 1 [/SUP], Wei Xu[SUP] 2 [/SUP], Shu-Wen Liu[SUP] 3 4 [/SUP]
Affiliations
- PMID: 32747721
- DOI: 10.1038/s41401-020-0485-4
Abstract
Coronavirus disease 2019 is a newly emerging infectious disease currently spreading across the world. It is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spike (S) protein of SARS-CoV-2, which plays a key role in the receptor recognition and cell membrane fusion process, is composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain that recognizes and binds to the host receptor angiotensin-converting enzyme 2, while the S2 subunit mediates viral cell membrane fusion by forming a six-helical bundle via the two-heptad repeat domain. In this review, we highlight recent research advance in the structure, function and development of antivirus drugs targeting the S protein.
Keywords: SARS-CoV-2 virus; antibodies; antivirus drugs; fusion inhibitors; host proteases inhibitors; spike protein.