tetano
Editor, Senior Moderator
Epidemiology and Infection
* Adult intensive-care patients with 2009 pandemic influenza A(H1N1) infection
* Epidemiology and Infection , FirstView article
* doi: 10.1017/S0950268810002414 (About doi)
* Published online by Cambridge University Press 26 Oct 2010
C. FUHRMANa1 c1, I. BONMARINa1, D. BITARa1, T. CARDOSOa1, N. DUPORTa1, M. HERIDAa1, H. ISNARDa1, B. GUIDETa2, O. MIMOZa3, J. C. M. RICHARDa4, C. BRUN-BUISSONa5, L. BROCHARDa5, A. MAILLESa1, A. C. PATYa1, C. SAURAa1 and D. L?VY-BRUHLa1
a1 French Institute for Public Health Surveillance (Institut de veille sanitaire, InVS), Saint-Maurice, France
a2 Medical Intensive Care Unit, Assistance Publique?H?pitaux de Paris, H?pital St Antoine, Paris, France
a3 Surgical Intensive Care Unit, University Hospital, Poitiers, France
a4 Medical Intensive Care Unit, University Hospital Charles Nicolle, Rouen, France
a5 Medical Intensive Care Unit, Assistance Publique?H?pitaux de Paris, University Hospital Henri Mondor, Cr?teil, France
SUMMARY
In France, the surveillance of hospitalized cases of pandemic influenza was implemented in July 2009 and restricted to intensive-care unit (ICU) patients in November. We described the characteristics of the 1065 adult patients admitted to ICUs and analysed risk factors for severe outcome (mechanical ventilation or death). Eighty-seven percent of cases were aged 15?64 years. The case-fatality ratio was 20%. The risk for severe outcome increased with age and obesity while this association was negative for chronic respiratory disease. Late antiviral therapy was associated with a severe outcome in ICU patients with risk factors (adjusted OR 2?0, 95% CI 1?4?3?0). This study confirms the considerable contribution of young adults to A(H1N1) 2009 mortality. It shows the role of obesity as an independent risk factor for severe disease, and of early antiviral therapy as a protective factor, at least in patients with risk factors.
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=7918086
* Adult intensive-care patients with 2009 pandemic influenza A(H1N1) infection
* Epidemiology and Infection , FirstView article
* doi: 10.1017/S0950268810002414 (About doi)
* Published online by Cambridge University Press 26 Oct 2010
C. FUHRMANa1 c1, I. BONMARINa1, D. BITARa1, T. CARDOSOa1, N. DUPORTa1, M. HERIDAa1, H. ISNARDa1, B. GUIDETa2, O. MIMOZa3, J. C. M. RICHARDa4, C. BRUN-BUISSONa5, L. BROCHARDa5, A. MAILLESa1, A. C. PATYa1, C. SAURAa1 and D. L?VY-BRUHLa1
a1 French Institute for Public Health Surveillance (Institut de veille sanitaire, InVS), Saint-Maurice, France
a2 Medical Intensive Care Unit, Assistance Publique?H?pitaux de Paris, H?pital St Antoine, Paris, France
a3 Surgical Intensive Care Unit, University Hospital, Poitiers, France
a4 Medical Intensive Care Unit, University Hospital Charles Nicolle, Rouen, France
a5 Medical Intensive Care Unit, Assistance Publique?H?pitaux de Paris, University Hospital Henri Mondor, Cr?teil, France
SUMMARY
In France, the surveillance of hospitalized cases of pandemic influenza was implemented in July 2009 and restricted to intensive-care unit (ICU) patients in November. We described the characteristics of the 1065 adult patients admitted to ICUs and analysed risk factors for severe outcome (mechanical ventilation or death). Eighty-seven percent of cases were aged 15?64 years. The case-fatality ratio was 20%. The risk for severe outcome increased with age and obesity while this association was negative for chronic respiratory disease. Late antiviral therapy was associated with a severe outcome in ICU patients with risk factors (adjusted OR 2?0, 95% CI 1?4?3?0). This study confirms the considerable contribution of young adults to A(H1N1) 2009 mortality. It shows the role of obesity as an independent risk factor for severe disease, and of early antiviral therapy as a protective factor, at least in patients with risk factors.
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=7918086