tetano
Editor, Senior Moderator
Aging (Albany NY)
. 2020 Jul 13;12.
doi: 10.18632/aging.103579. Online ahead of print.
Epidemiological, comorbidity factors with severity and prognosis of COVID-19: a systematic review and meta-analysis
Xiaoyu Fang[SUP] 1 2 [/SUP], Shen Li[SUP] 3 [/SUP], Hao Yu[SUP] 4 [/SUP], Penghao Wang[SUP] 3 [/SUP], Yao Zhang[SUP] 2 [/SUP], Zheng Chen[SUP] 2 [/SUP], Yang Li[SUP] 5 [/SUP], Liqing Cheng[SUP] 6 [/SUP], Wenbin Li[SUP] 7 [/SUP], Hong Jia[SUP] 1 [/SUP], Xiangyu Ma[SUP] 2 [/SUP]
Affiliations
Abstract
A systematic review and meta-analysis was conducted in an attempt to systematically collect and evaluate the associations of epidemiological, comorbidity factors with the severity and prognosis of coronavirus disease 2019 (COVID-19). The systematic review and meta-analysis was conducted according to the guidelines proposed by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Sixty nine publications met our study criteria, and 61 studies with more than 10,000 COVID-19 cases were eligible for the quantitative synthesis. We found that the males had significantly higher disease severity (RR: 1.20, 95% CI: 1.13-1.27, P <0.001) and more prognostic endpoints. Older age was found to be significantly associated with the disease severity and six prognostic endpoints. Chronic kidney disease contributed mostly for death (RR: 7.10, 95% CI: 3.14-16.02), chronic obstructive pulmonary disease (COPD) for disease severity (RR: 4.20, 95% CI: 2.82-6.25), admission to intensive care unit (ICU) (RR: 5.61, 95% CI: 2.68-11.76), the composite endpoint (RR: 8.52, 95% CI: 4.36-16.65,), invasive ventilation (RR: 6.53, 95% CI: 2.70-15.84), and disease progression (RR: 7.48, 95% CI: 1.60-35.05), cerebrovascular disease for acute respiratory distress syndrome (ARDS) (RR: 3.15, 95% CI: 1.23-8.04), coronary heart disease for cardiac abnormality (RR: 5.37, 95% CI: 1.74-16.54). Our study highlighted that the male gender, older age and comorbidities owned strong epidemiological evidence of associations with the severity and prognosis of COVID-19.
Keywords: 2019-nCoV; COVID-19; SARS-Cov-2; meta-analysis.
. 2020 Jul 13;12.
doi: 10.18632/aging.103579. Online ahead of print.
Epidemiological, comorbidity factors with severity and prognosis of COVID-19: a systematic review and meta-analysis
Xiaoyu Fang[SUP] 1 2 [/SUP], Shen Li[SUP] 3 [/SUP], Hao Yu[SUP] 4 [/SUP], Penghao Wang[SUP] 3 [/SUP], Yao Zhang[SUP] 2 [/SUP], Zheng Chen[SUP] 2 [/SUP], Yang Li[SUP] 5 [/SUP], Liqing Cheng[SUP] 6 [/SUP], Wenbin Li[SUP] 7 [/SUP], Hong Jia[SUP] 1 [/SUP], Xiangyu Ma[SUP] 2 [/SUP]
Affiliations
- PMID: 32658868
- DOI: 10.18632/aging.103579
Abstract
A systematic review and meta-analysis was conducted in an attempt to systematically collect and evaluate the associations of epidemiological, comorbidity factors with the severity and prognosis of coronavirus disease 2019 (COVID-19). The systematic review and meta-analysis was conducted according to the guidelines proposed by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Sixty nine publications met our study criteria, and 61 studies with more than 10,000 COVID-19 cases were eligible for the quantitative synthesis. We found that the males had significantly higher disease severity (RR: 1.20, 95% CI: 1.13-1.27, P <0.001) and more prognostic endpoints. Older age was found to be significantly associated with the disease severity and six prognostic endpoints. Chronic kidney disease contributed mostly for death (RR: 7.10, 95% CI: 3.14-16.02), chronic obstructive pulmonary disease (COPD) for disease severity (RR: 4.20, 95% CI: 2.82-6.25), admission to intensive care unit (ICU) (RR: 5.61, 95% CI: 2.68-11.76), the composite endpoint (RR: 8.52, 95% CI: 4.36-16.65,), invasive ventilation (RR: 6.53, 95% CI: 2.70-15.84), and disease progression (RR: 7.48, 95% CI: 1.60-35.05), cerebrovascular disease for acute respiratory distress syndrome (ARDS) (RR: 3.15, 95% CI: 1.23-8.04), coronary heart disease for cardiac abnormality (RR: 5.37, 95% CI: 1.74-16.54). Our study highlighted that the male gender, older age and comorbidities owned strong epidemiological evidence of associations with the severity and prognosis of COVID-19.
Keywords: 2019-nCoV; COVID-19; SARS-Cov-2; meta-analysis.